ChemicalBook >> CAS DataBase List >>1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile structure

CAS No.: 350797-56-7

Chemical Name:: 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

Synonyms: SL-5;Silodosin Nitro Impurity;3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate;1-(3-Benzoyloxypropyl)-7-cyano-5-(2-nitropropyl) indoline.;1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-in...;3-[7-cyano-5-(2-nitropropyl)-2,3-dihydroindol-1-yl]propyl benzoate;3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate (Silodosin Impurity);1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile;1H-Indole-7-carbonitrile, 1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-

CBNumber:: CB22546472

Molecular Formula:: C22H23N3O4

Molecular Weight:: 393.44

MDL Number:: MFCD17169997

MOL File:: 350797-56-7.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propylBenzoate	C982035	5g	$135
SilodosinImpurity9	J11149	25mg	$95
1-[3-(BENZOYLOXY)PROPYL]-2,3-DIHYDRO-5-(2-NITROPROPYL)-1H-INDOLE-7-CARBONITRILE 95.00%	CHM0129703	5MG	$499.76
1-[3-(BENZOYLOXY)PROPYL]-2,3-DIHYDRO-5-(2-NITROPROPYL)-1H-INDOLE-7-CARBONITRILE 95.00%	CHM0129703	25G	$1000
3-(7-cyano-5-(2-nitropropyl)indolin-1-yl)propylbenzoate 95%	CM148068	5g	$107
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1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Properties

Melting point	73-75°C
Boiling point	608.6±55.0 °C(Predicted)
Density	1.27
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	7.80±0.13(Predicted)
form	Solid
color	Light Yellow to Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C982035	3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propylBenzoate	350797-56-7	5g	$135	2021-12-16	Buy
AK Scientific	J11149	SilodosinImpurity9	350797-56-7	25mg	$95	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0129703	1-[3-(BENZOYLOXY)PROPYL]-2,3-DIHYDRO-5-(2-NITROPROPYL)-1H-INDOLE-7-CARBONITRILE 95.00%	350797-56-7	5MG	$499.76	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0129703	1-[3-(BENZOYLOXY)PROPYL]-2,3-DIHYDRO-5-(2-NITROPROPYL)-1H-INDOLE-7-CARBONITRILE 95.00%	350797-56-7	25G	$1000	2021-12-16	Buy
Chemenu	CM148068	3-(7-cyano-5-(2-nitropropyl)indolin-1-yl)propylbenzoate 95%	350797-56-7	5g	$107	2021-12-16	Buy

Product number	Packaging	Price	Buy
C982035	5g	$135	Buy
J11149	25mg	$95	Buy
CHM0129703	5MG	$499.76	Buy
CHM0129703	25G	$1000	Buy
CM148068	5g	$107	Buy

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Chemical Properties,Uses,Production

Uses

3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl Benzoate is used in the preparation of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.

Synthesis

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde

350797-55-6

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

350797-56-7

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde (20.0 g) was used as a starting material and dissolved in tetrahydrofuran (29.0 ml). To this solution, hydroxylamine hydrochloride (4.21 g) and pyridine (16.0 ml) were added sequentially. The reaction mixture was stirred at a constant temperature at 50 °C for 2 h. Acetic anhydride (9.0 ml) was subsequently added. Stirring of the reaction mixture was continued at 80°C for 2 hours. After completion of the reaction, extraction was carried out with toluene. The toluene layer obtained by extraction was washed with dilute hydrochloric acid, after which the solvent was removed by distillation under reduced pressure to give 16.0 g of propyl 3-(7-cyano-5-(2-nitropropyl)dihydroindol-1-yl)benzoate (Compound XX).

References

[1] Patent: WO2011/124704, 2011, A1. Location in patent: Page/Page column 19-20
[2] Patent: WO2013/56842, 2013, A1. Location in patent: Page/Page column 19
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 8, p. 3826 - 3839

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Preparation Products And Raw materials

Raw materials

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde Hydroxylamine hydrochloride Tetrahydrofuran Pyridine Acetic anhydride

Preparation Products

5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile Silodosin

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Suppliers

Global( 103)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-17392712697	1022@dideu.com	China	3995	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5240	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21595	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2952	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Chemsigma International Co., Ltd.	+86-2558742998 +86-19951791336	info@chemsigma.com	China	1801	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Jinan Finer Chemical Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Chemsigma International Co., Ltd.	58

View Lastest Price from 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-24	1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 350797-56-7	US $0.10 / KG	1KG	99.0%	1000Tons	Shaanxi Dideu Medichem Co. Ltd
2025-12-01	1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 350797-56-7	US $0.00 / kg	1kg	98%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-05-26	Silodosin 350797-56-7	US $10.50 / KG	1KG	99%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
350797-56-7
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
350797-56-7
US $0.00 / kg
98%
Shaanxi Dideu New Materials Co. Ltd

Silodosin
350797-56-7
US $10.50 / KG
99%
Hebei Chuanghai Biotechnology Co,.LTD

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Spectrum

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile(350797-56-7)¹HNMR

350797-56-7(1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile)Related Search:

Silodosin Impurity 18 Silodosin β-D-Glucuronide N-Carboxybenzyl O-Methyl Tri-acetate Silodosin Impurity 26 NCFJJNFEEPMRAQ-XMMPIXPASA-N Silodosin

5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate Silodosin 1H-Indole-7-carbonitrile, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]- O-Acetyl Silodosin 1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-1H-indole-7-carboxaMide

Silodosin Carboxylic Acid Impurity (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-1-(3-hydroxypropyl)indoline-7-carboxamide(WXG00186) Silodosin β-D-Glucuronide Sodium Salt Silodosin Glucuronide Silodosin-d4 (Chiral)

5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile Silodosin Impurity 33 Silodosin-d6

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3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate SL-5 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-in... Silodosin Nitro Impurity 1H-Indole-7-carbonitrile, 1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)- 3-[7-cyano-5-(2-nitropropyl)-2,3-dihydroindol-1-yl]propyl benzoate 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate (Silodosin Impurity) 1-(3-Benzoyloxypropyl)-7-cyano-5-(2-nitropropyl) indoline. 350797-56-7