ChemicalBook >> CAS DataBase List >>L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine structure

CAS No.: 1337482-17-3

Chemical Name:: L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine

Synonyms: Sofosbuvir 3';Sofosbuvir Dimer;5'-Bis-(S)-phosphate;Sofosbuvir impurity F;Sofosbuvir 3’,5’-Bis-(S)-phosphate;Inhibitor,HCV,Sofosbuvir impurity F,inhibit,Hepatitis C virus;isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosph;isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alanite;isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate;(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate

CBNumber:: CB22716264

Molecular Formula:: C34H45FN4O13P2

Molecular Weight:: 798.69

MDL Number:: MFCD28386697

MOL File:: 1337482-17-3.mol

Last updated:2023-05-21 10:59:17

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L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine Properties

Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	9.39±0.10(Predicted)

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	S675605	Sofosbuvir3'',5''-Bis-(S)-phosphate	1337482-17-3	250mg	$1320	2021-12-16	Buy
ChemScene	CS-7849	SofosbuvirimpurityF	1337482-17-3	1mg	$1800	2021-12-16	Buy
Medical Isotopes, Inc.	67030	Sofosbuvir3??,5??-Bis-(S)-phosphate	1337482-17-3	250mg	$2200	2021-12-16	Buy
ChemScene	CS-7849	SofosbuvirimpurityF	1337482-17-3	5mg	$4200	2021-12-16	Buy
Medical Isotopes, Inc.	67030	Sofosbuvir3??,5??-Bis-(S)-phosphate	1337482-17-3	25mg	$650	2021-12-16	Buy

Product number	Packaging	Price	Buy
S675605	250mg	$1320	Buy
CS-7849	1mg	$1800	Buy
67030	250mg	$2200	Buy
CS-7849	5mg	$4200	Buy
67030	25mg	$650	Buy

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine Chemical Properties,Uses,Production

Uses

Sofosbuvir 3'',5''-Bis-(S)-phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Uses

Sofosbuvir Impurity

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine Preparation Products And Raw materials

Raw materials

Preparation Products

L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine Suppliers

Global( 51)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3149	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
China National Standard Pharmaceutical Corporation Limited	+8615391658522	overseasales@yongstandards.com	China	11927	58
Beijing Comparison Pharmaceutical Technology Co., Ltd	010-52878169 15701683040	sales@bjcomparison.com	China	4673	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632	sales@reading-chemicals.com	China	15185	58
Haixi Pharmaceuticals	0591-87519936-3020 18060579623	yuanhong.lai@hxpharma.com	China	13	65

Supplier	Advantage
Standardpharm Co. Ltd.	58
TargetMol Chemicals Inc.	58
BOC Sciences	58
Hangzhou Huarong Pharm Co., Ltd.	58
sgtlifesciences pvt ltd	58
China National Standard Pharmaceutical Corporation Limited	58
Beijing Comparison Pharmaceutical Technology Co., Ltd	58
MedChemexpress LLC	58
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Haixi Pharmaceuticals	65

1337482-17-3(L-Alanine, N-[(S)-hydroxyphenoxyphosphinyl]-, 1-Methylethyl ester, (P→3'),(P'→5')-diester with (2'R)-2'-deoxy-2'-fluoro-2'-Methyluridine)Related Search:

Sofosbuvir Impurity Sofosbuvir (2R,3R,4R,5R)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-chloro-4-Methyltetrahydrofuran-3-yl benzoate 1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione Sofosbuvir metabolites

D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester SofosBuvir impurity 44 1-((2R,3R,4R,5R)-3-chloro-4-hydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Sofosbuvir impurity D SofosBuvir Impurity 52

PSI-7976 N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Sofosbuvir Impurity 67 SofosBuvir Impurity 14 (S)-methyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

(2R,3R,4R,5S)-5-(4-benzaMido-2-oxopyriMidin-1(2H)-yl)-2-((benzoyloxy)Methyl)-4-fluoro-4-Methyltetrahydrofuran-3-yl benzoate SofosBuvir Impurity 50 Sofosbuvir Impurity23

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Sofosbuvir Dimer isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alaninate Sofosbuvir impurity F Sofosbuvir 3’,5’-Bis-(S)-phosphate (2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)amino)propanoate Sofosbuvir impurity 19/Sofosbuvir 3',5'-Bis-O-Phosphoramidate//Isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3 isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3-yl)oxy)(phenoxy)phosphoryl)-L-alanite isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosph Sofosbuvirimpurity19/Sofosbuvir3',5'-Bis-O-Phosphoramidate//Isopropyl((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1Chemicalbook(2H)-yl)-4-fluoro-2-((((S)-(((S)-1-isopropoxy-1-oxopropan-2-yl)amino)(phenoxy)phosphoryl)oxy)methyl)-4-methyltetrahydrofuran-3 5'-Bis-(S)-phosphate Sofosbuvir 3' Inhibitor,HCV,Sofosbuvir impurity F,inhibit,Hepatitis C virus 1337482-17-3 C34H45FN4O13P2