ReModelin hydrobroMide
- CAS No.
- 1622921-15-6
- Chemical Name:
- ReModelin hydrobroMide
- Synonyms
- CS-1751;Remodelin HBR;ReModelin hydrobroMide;ReModelin hydrobroMide USP/EP/BP;4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile;4-(2-(2-Cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile hydrobromide;4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile, hydrobromide (1:1);Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1);HGPS,inhibit,telomerase,N-acetyltransferase,HATs,HAT,migration,Remodelin hydrobromide,Inhibitor,HCC,Histone Acetyltransferase;Remodelin 16066 Remodelin (hydrobromide) 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile
- CBNumber:
- CB22729374
- Molecular Formula:
- C15H15BrN4S
- Molecular Weight:
- 363.2754
- MDL Number:
- MFCD28137688
- MOL File:
- 1622921-15-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
ReModelin hydrobroMide price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16066 | Remodelin (hydrobromide) ≥98% | 1622921-15-6 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16066 | Remodelin (hydrobromide) ≥98% | 1622921-15-6 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 16066 | Remodelin (hydrobromide) ≥98% | 1622921-15-6 | 10mg | $283 | 2024-03-01 | Buy |
| TRC | R143650 | Remodelin hydrobromide | 1622921-15-6 | 50mg | $350 | 2021-12-16 | Buy |
| TRC | R143650 | Remodelin hydrobromide | 1622921-15-6 | 1mg | $45 | 2021-12-16 | Buy |
ReModelin hydrobroMide Chemical Properties,Uses,Production
Uses
Remodelin acts as a potent acetyl-transferase NAT10 inhibitor, which is shown to correct defects of laminopathic cells. Anti-aging.
Biological Activity
remodelin is a potent inhibitor of nat10 [1].n-acetyltransferase 10 (nat10) is the only identified lysine acetyltransferase that acts on microtubules and histones [1]. nat10 mainly exists in the nucleolus.remodelin is a potent nat10 inhibitor. in lamin a/c depletion (silmna) cells, remodelin remodeled nuclear architecture through inhibition of nat10 lysine acetyltransferase activity. in cells derived from lmna-mutated hgps patients and primary mrc5 fibroblasts aged in culture, remodelin significantly decreased the prevalence of misshapen nuclei. in u2os cells and normal fibroblasts, remodelin inhibited nuclear shape defects induced by farnesyltransferase inhibitors (fti). in hgps cells, remodelin reduced the amount of misshapen nuclei, suggesting that inhibition of nat10 mediated nuclear shape normalization. also, remodelin reduced dna damage signaling, reduced sun1 accumulation at the nuclear envelope, reduced the levels of autophosphorylated atm and dna double-strand break markers γh2ax, and improved chromatin and nucleolar organization. in silmna and hgps cells, remodelin inhibited microtubule anchorage to centrosomes [1].
References
[1]. larrieu d, britton s, demir m, et al. chemical inhibition of nat10 corrects defects of laminopathic cells. science, 2014, 344(6183): 527-532.
ReModelin hydrobroMide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
View Lastest Price from ReModelin hydrobroMide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-31 | Remodelin (hydrobromide)
1622921-15-6
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- Remodelin (hydrobromide)
1622921-15-6
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co