ALPHA-HYDROXYALPRAZOLAM
- CAS No.
- 37115-43-8
- Chemical Name:
- ALPHA-HYDROXYALPRAZOLAM
- Synonyms
- A-HYDROXYALPRAZOLAM;α-Hydroxyalprazolam;α-hydroxy Alprazolam;ALPHA-HYDROXYALPRAZOLAM;Piraxostat Impurity 27;-hydroxy Alprazolam (CRM);α-hydroxy Alprazolam (CRM);alpha-Hydroxyalprazolam solution;α-hydroxyalprazolam Solution, 100ppm;ALPHA-HYDROXYALPRAZOLAM,100/MLINMETHANOL
- CBNumber:
- CB2313681
- Molecular Formula:
- C17H13ClN4O
- Molecular Weight:
- 324.76
- MDL Number:
- MFCD00171226
- MOL File:
- 37115-43-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| alpha-Hydroxyalprazolam solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | A-907 | 1mL | $118 |
| α-hydroxy Alprazolam (CRM) | 25517 | 1mg | $87 |
| α-hydroxy Alprazolam ≥98% | 15287 | 1mg | $90 |
| α-hydroxy Alprazolam ≥98% | 15287 | 5mg | $391 |
| α-hydroxy Alprazolam ≥98% | 15287 | 1mg | $81 |
| Melting point | 129-134°C |
|---|---|
| Flash point | 9℃ |
| storage temp. | -20°C Freezer |
| solubility | methylene chloride: ~20 mg/mL, clear, colorless to faintly yellow |
| form | powder |
| color | white to off-white |
| Major Application | clinical testing |
| InChI | 1S/C17H13ClN4O/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)19-9-15-20-21-16(10-23)22(14)15/h1-8,23H,9-10H2 |
| InChIKey | ZURUZYHEEMDQBU-UHFFFAOYSA-N |
| SMILES | OCc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12 |
| FDA UNII | V7J2Z5Y50U |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| target organs | Eyes,Central nervous system | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 20/21/22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 36-45-36/37-16-7 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
|||||||||
| NFPA 704 |
|
ALPHA-HYDROXYALPRAZOLAM price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A-907 | alpha-Hydroxyalprazolam solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 37115-43-8 | 1mL | $118 | 2026-04-30 | Buy |
| Cayman Chemical | 25517 | α-hydroxy Alprazolam (CRM) | 37115-43-8 | 1mg | $87 | 2026-04-30 | Buy |
| Cayman Chemical | 15287 | α-hydroxy Alprazolam ≥98% | 37115-43-8 | 1mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 15287 | α-hydroxy Alprazolam ≥98% | 37115-43-8 | 5mg | $391 | 2026-04-30 | Buy |
| Cayman Chemical | 15287 | α-hydroxy Alprazolam ≥98% | 37115-43-8 | 1mg | $81 | 2024-03-01 | Buy |
ALPHA-HYDROXYALPRAZOLAM Chemical Properties,Uses,Production
Description
α-hydroxy Alprazolam (Item No. 15287) is an analytical reference material categorized as a benzodiazepine. It is a major active metabolite of alprazolam (CRM) that has a higher urinary recovery than 4-hydroxy alprazolam , another major metabolite. α-hydroxy Alprazolam has a lower binding affinity than alprazolam for the GABAA receptor. It is also a metabolite of adinazolam . This product is intended for research and forensic applications.
Chemical Properties
Yellow solid
Uses
A metabolite of Alprazolam, an anxiolytic
Definition
ChEBI: Alpha-Hydroxyalprazolam is a triazolobenzodiazepine.
General Description
A major urinary metabolite of the benzodiazepine alprazolam. Alprazolam, commonly sold under the trade name Xanax, is a short-acting anxiolytic approved to treat panic and other anxiety disorders including generalized or social anxiety disorder. This certified Snap-N-Spike solution standard is suitable for use in LC/MS or GC/MS applications such as forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring.
References
[1] D J GREENBLATT C E W. Clinical pharmacokinetics of alprazolam. Therapeutic implications.[J]. Clinical Pharmacokinetics, 1993, 24 6: 453-471. DOI: 10.2165/00003088-199324060-00003
[2] MIOK SHIN. Screening of multiple drugs of abuse and metabolites in urine using LC/MS/MS with polarity switching electrospray ionization[J]. Archives of Pharmacal Research, 2013, 37 6: 760-772. DOI: 10.1007/s12272-013-0225-0
[3] ANNIKA ALLQVIST. Simultaneous quantification of alprazolam, 4- and α-hydroxyalprazolam in plasma samples using liquid chromatography mass spectrometry[J]. Journal of Chromatography B, 2005, 814 1: Pages 127-131. DOI: 10.1016/j.jchromb.2004.10.012
[4] A D FRASER W B A F Isner. Urinary screening for adinazolam and its major metabolites by the Emit d.a.u. and FPIA benzodiazepine assays with confirmation by HPLC.[J]. Journal of analytical toxicology, 1993, 17 7: 427-431. DOI: 10.1093/jat/17.7.427
ALPHA-HYDROXYALPRAZOLAM Preparation Products And Raw materials
Raw materials
Preparation Products
ALPHA-HYDROXYALPRAZOLAM Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
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| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9679 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44896 | 58 |
| LGC Science (Shanghai) Ltd. | 17717235263 | cindy.yang@lgcgroup.com | China | 18217 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12582 | 58 |
