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15(R)-PROSTAGLANDIN D2

15(R)-PROSTAGLANDIN D2 Structure
15(R)-PROSTAGLANDIN D2 structure
CAS No.
59894-05-2
Chemical Name:
15(R)-PROSTAGLANDIN D2
Synonyms
15(R)-PROSTAGLANDIN D2;BHMBVRSPMRCCGG-DFVNJMEGSA-N;9ALPHA,15R-DIHYDROXY-11-OXO-PROSTA-5E,13E-DIEN-1-OIC ACID;Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15R)-
CBNumber:
CB2372167
Molecular Formula:
C20H32O5
Molecular Weight:
352.47
MDL Number:
MFCD18432679
MOL File:
Mol file
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:22:32
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15(R)-PROSTAGLANDIN D2 Properties

Boiling point 549.6±50.0 °C(Predicted)
Density 1.148±0.06 g/cm3(Predicted)
solubility DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.4): 1 mg/ml
pka 4.76±0.10(Predicted)
form Liquid
color Colorless to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

15(R)-PROSTAGLANDIN D2 price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10118 15(R)-Prostaglandin D2 ≥98% 59894-05-2 1mg $117 2026-04-30 Buy
Cayman Chemical 10118 15(R)-Prostaglandin D2 ≥98% 59894-05-2 5mg $514 2026-04-30 Buy
ChemScene CS-0137615 15(R)-Prostaglandin D2 99.9% 59894-05-2 5mg(28.37mM*500??LinMethylacetate) $1113 2026-06-04 Buy
aablocks AA00EBHK 15(R)-Prostaglandin D2 ≥98% 59894-05-2 1mg $117 2026-05-28 Buy
aablocks AA00EBHK 15(R)-Prostaglandin D2 ≥98% 59894-05-2 5mg $514 2026-05-28 Buy
Product number Packaging Price Buy
10118 1mg $117 Buy
10118 5mg $514 Buy
CS-0137615 5mg(28.37mM*500??LinMethylacetate) $1113 Buy
AA00EBHK 1mg $117 Buy
AA00EBHK 5mg $514 Buy

15(R)-PROSTAGLANDIN D2 Chemical Properties, Uses, Production

Description

Many of the effects of prostaglandin D2 (PGD2) are transduced via a traditional 7-transmembrane GPCR, the DP1 receptor.1 However, in certain leukocytes and other immune cells, a second PGD2 receptor referred to as the CRTH2 or DP2 receptor has been cloned and characterized.2,3 15(R)-15-methyl PGD2 is a surprisingly potent agonist at the DP2 receptor, being about 5 times more potent than PGD2 itself.4 15(R)-PGD2 has the potential to be produced endogenously as a natural ligand for DP2, unlike the synthetic 15-methyl analogs. In preliminary reports, 15(R)-PGD2 has also been reported to be a potent and selective DP2 receptor agonist.5,6

Uses

15(R)-Prostaglandin D2 is a potential prostatic hormone DP(2) receptor (Prostaglandin Receptor) agonist with anti-inflammatory activity. 15(R)-Prostaglandin D2 increases actin polymerization in human eosinophils and increases cAMP levels in platelets[1].

Definition

ChEBI: 15R-PGD2 is a prostanoid.

References

1. Boie, Y., Sawyer, N., Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor J. Biol. Chem. 270(32),18910-18916(1995).
2. Abe, H., Takeshita, T., Nagata, K., et al. Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family Gene 227,71-77(1999).
3. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193(2),255-261(2001).
4. Monneret, G., Cossette, C., Gravel, S., et al. 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils J. Pharmacol. Exp. Ther. 304(1),349-355(2003).
5. Kim, S., Bellone, S., Maxey, K.M., et al. Synthesis of 15R-PGD2: A potential DP2 receptor agonist Bioorg. Med. Chem. Lett. 15(7),1873-1876(2005).
6. Cossette, C., Walsh, S.E., Kim, S., et al. Agonist and antagonist effects of 15R-prostaglandin (PF) D2 and 11-methylene-PGD2 on human eosinophils and basophils J. Pharmacol. Exp. Ther. 320(1),173-179(2007).

15(R)-PROSTAGLANDIN D2 Preparation Products And Raw materials

Raw materials

Preparation Products

15(R)-PROSTAGLANDIN D2 Suppliers

Global Suppliers ( 17)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29873 58
Supplier Advantage
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

59894-05-2 (15(R)-PROSTAGLANDIN D2) Related Search:

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15(R)-PROSTAGLANDIN D2 9ALPHA,15R-DIHYDROXY-11-OXO-PROSTA-5E,13E-DIEN-1-OIC ACID BHMBVRSPMRCCGG-DFVNJMEGSA-N Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15R)- 59894-05-2