R-(+)-ETOMOXIR
- CAS No.
- 124083-20-1
- Chemical Name:
- R-(+)-ETOMOXIR
- Synonyms
- B80754;CS-1432;B807-54;B 80754;B-80754;B 807-54;B-807-54;S-(+)-ETOMOXIR;R-(+)-ETOMOXIR;R(+)-Etomoxir free acid
- CBNumber:
- CB2407236
- Molecular Formula:
- C17H23ClO4
- Molecular Weight:
- 326.82
- MDL Number:
- MFCD11227266
- MOL File:
- 124083-20-1.mol
| Melting point | 32-34°C |
|---|---|
| Boiling point | 405.0±25.0 °C(Predicted) |
| Density | 1.163 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | ≥32.7 mg/mL in DMSO; ≥109.6 mg/mL in EtOH; ≥48.3 mg/mL in H2O with gentle warming |
| form | Powder |
| FDA UNII | MSB3DD2XP6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
R-(+)-ETOMOXIR price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E933505 | R-(+)-Etomoxir | 124083-20-1 | 50mg | $1620 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 10182 | S-(+)-Etomoxir | 124083-20-1 | 25mg | $2000 | 2021-12-16 | Buy |
| ApexBio Technology | A3404 | Etomoxir | 124083-20-1 | 10mg | $120 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002658 | Etomoxir 95.00% | 124083-20-1 | 10MG | $303.45 | 2021-12-16 | Buy |
| ApexBio Technology | A3404 | Etomoxir | 124083-20-1 | 50mg | $510 | 2021-12-16 | Buy |
R-(+)-ETOMOXIR Chemical Properties,Uses,Production
Description
Etomoxir, or 2[6(4-chlorophenoxy)hexyl]oxirane-2-carboxylate, is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.This prevents the formation of acyl carnitines, a step that is necessary for the transport of fatty acyl chains from the cytosol into the intermembrane space of the mitochondria. This step is essential to the production of ATP from fatty acid oxidation. Etomoxir has also been identified as a direct agonist of PPARα. An off-target effect has been demonstrated at high concentrations of etomoxir on Coenzyme-A (CoA) metabolism.
Application
Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
Chemical Properties
Colourless Oil
Uses
An inhibitor of carnitine palmitoyltransferase A (CPT1), which is required for the oexidation of long-chain acyl CoA esters. A strong inhibitor of mitochondrial CPT1 and is a candidate as an anti-diabetic drug
Definition
ChEBI: (2R)-2-[6-(4-chlorophenoxy)hexyl]-2-oxiranecarboxylic acid ethyl ester is an aromatic ether.
Biological Activity
etomoxir is a cell-permeable, irreversible, and stereospecific compound. etomoxir is shown to inhibit carnitine palmitoyltransferase (cpt)-1 and dgat activity in the mitochondria of rat heart h9c2 myoblastic cells at a concentration of 1-80 μm and 40 μm, respectively.
R-(+)-ETOMOXIR Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
Related articles
- Biological activity of Etomoxir
- Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid ox....
- Oct 29，2019
View Lastest Price from R-(+)-ETOMOXIR manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Etomoxir
124083-20-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Etomoxir
124083-20-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-13 | Etomoxir
124083-20-1
|
US $1.00 / g | 1g | 95-99% | 1ton | Career Henan Chemical Co |