3-Chloro-1-propanol
- CAS No.
- 627-30-5
- Chemical Name:
- 3-Chloro-1-propanol
- Synonyms
- 3-CHLOROPROPAN-1-OL;3-Chloropropanol;TRIMETHYLENE CHLOROHYDRIN;1-Propanol, 3-chloro-;3-Chloropropyl alcohol;NSC 60190;Chloro-1-propa;oro-1-propanoL;3-CHLORPROPANOL;Chloro-1-propanol
- CBNumber:
- CB2407458
- Molecular Formula:
- C3H7ClO
- Molecular Weight:
- 94.54
- MDL Number:
- MFCD00002943
- MOL File:
- 627-30-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-Chloro-1-propanol 98% | C46403 | 25g | $48.2 |
| 3-Chloro-1-propanol 98% | C46403 | 100g | $101 |
| 3-Chloro-1-propanol >98.0%(GC) | C0270 | 25g | $36 |
| 3-Chloro-1-propanol >98.0%(GC) | C0270 | 100g | $83 |
| 3-Chloro-1-propanol 98% | C46403 | 500g | $209 |
| More product size | |||
| Melting point | -20 °C |
|---|---|
| Boiling point | 160-162 °C(lit.) |
| Density | 1.131 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 164 °F |
| storage temp. | 0-6°C |
| solubility | 50g/l (slow decomposition) |
| form | Liquid |
| pka | 14.73±0.10(Predicted) |
| Specific Gravity | 1.14 |
| color | Clear colorless to yellow |
| PH | 3-4 (100g/l, H2O, 20℃) |
| Water Solubility | 300 g/L (20 ºC) |
| BRN | 773655 |
| Exposure limits | No exposure limit is set. A TLV-TWA air value of 100 ppm (approximately 400 mg/m3) is suggested for this compound. |
| Stability | Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | LAMUXTNQCICZQX-UHFFFAOYSA-N |
| CAS DataBase Reference | 627-30-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 148011U61G |
| NIST Chemistry Reference | 1-Propanol, 3-chloro-(627-30-5) |
| EPA Substance Registry System | 3-Chloro-1-propanol (627-30-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| RIDADR | UN 2849 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UA8930000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29055910 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3-Chloro-1-propanol price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C46403 | 3-Chloro-1-propanol 98% | 627-30-5 | 25g | $48.2 | 2025-07-31 | Buy |
| Sigma-Aldrich | C46403 | 3-Chloro-1-propanol 98% | 627-30-5 | 100g | $101 | 2025-07-31 | Buy |
| TCI Chemical | C0270 | 3-Chloro-1-propanol >98.0%(GC) | 627-30-5 | 25g | $36 | 2025-07-31 | Buy |
| TCI Chemical | C0270 | 3-Chloro-1-propanol >98.0%(GC) | 627-30-5 | 100g | $83 | 2025-07-31 | Buy |
| Sigma-Aldrich | C46403 | 3-Chloro-1-propanol 98% | 627-30-5 | 500g | $209 | 2025-07-31 | Buy |
3-Chloro-1-propanol Chemical Properties,Uses,Production
Chemical Properties
Colorless to pale-yellow liquid; characteristic odor. Soluble in water, alcohols, and ethers; insoluble in hydrocarbons. Combustible.
Uses
3-Chloro-1-propanol is used in organicsynthesis to produce cyclopropane andtrimethylene oxide. It is an intermediate inthe synthesis of pharmaceuticals, agrochemicals, antiseptic agents, and dyes. It is an inhibitor of triosephosphate isomerase and glyceraldehyde 3-phosphate dehydrogenase.
Preparation
3-Chloro-1-propanol is synthesized by the reaction of 1, 3-propanediol and hydrochloric acid, using benzene sulfonic acid as the catalyst.
Reaction: 250 g of trimethylene glycol are shaken with 450 g of sulfur chloride, the mixture becoming warm, sulfur dioxide being rapidly evolved, and sulfur deposited. This reaction continues for 1 hours without heating, whereafter the mixture is heated for a further 6 hours on the water-bath and then for 30 min, over a free flame. When no more sulfur dioxide is evolved, the mixture is allowed to cool, then extracted several times with ether. The sulfur is washed with ether, and the united ethereal layers are shaken with sodium carbonate solution to remove sulfur dioxide, dried over sodium sulfate, and freed from ether. The residue is fractionated and the fraction of b.p. 140-180° C is redistilled, giving 60% (160 g) of 3-chloro-1-propanol, b.p. 160-164°C/760 mm, 60-64° C/10 mm.
J. Amer. Chem. Soc, 38, 2481 (1916)
J. Chem. Soc, 1928, 2439
Synthesis Reference(s)
Journal of the American Chemical Society, 90, p. 2927, 1968 DOI: 10.1021/ja01013a033
The Journal of Organic Chemistry, 55, p. 2968, 1990 DOI: 10.1021/jo00296a078
Organic Syntheses, Coll. Vol. 1, p. 533, 1941
General Description
3-Chloro-1-propanol appears as a colorless liquid with a mild odor. Slightly denser than water. Toxic by ingestion and inhalation . Flash point 270°F. Used to make plastics, resins and other chemicals.
Reactivity Profile
3-Chloro-1-propanol may be sensitive to prolonged exposure to light. 3-Chloro-1-propanol may react with oxidizing agents. .
Health Hazard
3-Chloro-1-propanol also know as Trimethylene chlorohydrin, is a moderatelytoxic compound. Skin contact can cause irritation.Ingestion can result in CNSdepression, muscle contraction, gastrointesti nal pain, and ulceration or stomach bleed ing. High dosage can cause liver injury. Thetoxicity of this compound, however, is lesssevere than that of its isomer, propylene β-chlorohydrin.
LD50 value, oral (mice): 2300 mg/kg
Fire Hazard
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Safety Profile
Moderately toxic by ingestion. Mutation data reported. Chloropropanols have mutagenic and carcinogenic properties. The 3-monochloropropanol (3-MCPD) is the main chloropropanol found in hydrolyzates of vegetable protein (HVP) made by acid hydrolysis.
Toxics Screening Level
The ITSL for 3-chloro-1-propanol has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.
Waste Disposal
Trimethylene chlorohydrin is burned in achemical incinerator equipped with an afterburner and scrubber.
3-Chloro-1-propanol Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10237 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9081 | 58 |
| Zouping mingyuan import & export trading co., ltd | +86-0543-2240078 +8618364991597 | myzhao793@163.com | China | 981 | 58 |
| Sichuan Zhuoyu Yantang Technology Co., Ltd. | +8613288715578 | sales@sichuanzyyt.com | China | 12245 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Taixing Foreign Trade Nanjing Co., Ltd. | +86-025-83346564; +8613182976929 | sales@tx-chem.com | China | 123 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21618 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2988 | 55 |
View Lastest Price from 3-Chloro-1-propanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-08 | 3-Chloro-1-propanol
627-30-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Sichuan Zhuoyu Yantang Technology Co., Ltd. | |
 |
2025-08-05 | 3-Chloro-1-propanol
627-30-5
|
US $0.00 / kg | 1kg | 99% | 10 tons | Zouping mingyuan import & export trading co., ltd | |
 |
2025-06-20 | 3-Chloro-1-propanol
627-30-5
|
US $0.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- 3-Chloro-1-propanol
627-30-5
- US $0.00 / KG
- 99%
- Sichuan Zhuoyu Yantang Technology Co., Ltd.
-
- 3-Chloro-1-propanol
627-30-5
- US $0.00 / kg
- 99%
- Zouping mingyuan import & export trading co., ltd
-
- 3-Chloro-1-propanol
627-30-5
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
