Quinidine sulfate dihydrate
- CAS No.
- 6591-63-5
- Chemical Name:
- Quinidine sulfate dihydrate
- Synonyms
- Quinidin;Unii-J13S2394he;Pitayine Sodium;Chinidin Sodium;β-quinine Sodium;β-quinine Sodium;QUINIDINE SULFATE;(S) Quinine Sulfate;Quinidine sulfate CRS;QUINIDINE SULFATE 99+%
- CBNumber:
- CB2471189
- Molecular Formula:
- C20H26N2O6S
- Molecular Weight:
- 422.5
- MDL Number:
- MFCD00149346
- MOL File:
- 6591-63-5.mol
- MSDS File:
- SDS
| Melting point | 212-214 °C (dec.)(lit.) |
|---|---|
| alpha | [α]D20 +260～+270° (c=5, dil. HCl.10min) |
| refractive index | 275 ° (C=2, 0.1mol/L HCl) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Slightly soluble in water, soluble in boiling water and in ethanol (96 per cent), practically insoluble in acetone. |
| color | White to Off-White |
| Water Solubility | Soluble in chloroform, water (11 mg/ml at 20°C), alcohol, and ethanol (50 mg/ml). |
| Sensitive | Light Sensitive |
| Merck | 14,8060 |
| InChIKey | AKYHKWQPZHDOBW-ZAXYGKDDNA-N |
| SMILES | [C@@H]([C@@]1([H])C[C@@H]2CC[N@]1C[C@@H]2C=C)(C1=CC=NC2=CC=C(OC)C=C12)O.S(O)(O)(=O)=O |&1:0,1,4,7,9,r| |
| CAS DataBase Reference | 6591-63-5(CAS DataBase Reference) |
| FDA UNII | J13S2394HE |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-20/21/22 |
| Safety Statements | 13-36 |
| RIDADR | UN 2811 6.1/PG III |
| WGK Germany | 3 |
| RTECS | VA5605000 |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 2939200050 |
Quinidine sulfate dihydrate price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Q0875 | Quinidine sulfate salt dihydrate | 6591-63-5 | 10g | $106 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR3233 | Quinidine Sulfate pharmaceutical secondary standard, certified reference material | 6591-63-5 | 1G | $173 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1595509 | Quinidine sulfate United States Pharmacopeia (USP) Reference Standard | 6591-63-5 | 500mg | $436 | 2024-03-01 | Buy |
| Alfa Aesar | J60426 | Quinidine sulfate dihydrate, 98+% | 6591-63-5 | 5g | $50.65 | 2024-03-01 | Buy |
| Alfa Aesar | J60426 | Quinidine sulfate dihydrate, 98+% | 6591-63-5 | 25g | $185.65 | 2024-03-01 | Buy |
Quinidine sulfate dihydrate Chemical Properties,Uses,Production
Chemical Properties
Quinidine sulfate dihydrate is white to light yellow crystal powde
Uses
antiarrhythmic, antimalarial
Uses
Quinidine sulfate dihydrate (cas# 6591-63-5) is the hydrated, sulfate salt of Quinidine (Q685000), a dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.
brand name
Cin-Quin (Solvay Pharmaceuticals); Quinidex (Wyeth); Quinora (Schering).
General Description
Quinidine sulfate dihydrate is the sulfateof an alkaloid obtained from various species ofCinchona and their hybrids. It is a dextrorotatory diastereoisomerof quinine. The salt crystallizes from wateras the dihydrate, in the form of fine, needlelike, white crystals.Quinidine sulfate contains a hydroxymethyl groupthat serves as a link between a quinoline ring and a quinuclidinemoiety. The structure contains two basic nitrogens,of which the quinuclidine nitrogen is the stronger base(pKa 10). Quinidine sulfate dihydrate is bitter and light sensitive.Quinidine sulfate dihydrates are nearly neutral or slightly alkaline. Itis soluble to the extent of 1% in water and more highly solublein alcohol or chloroform.
Biochem/physiol Actions
Class IA antiarrhythmic; potassium channel blocker.
Clinical Use
Quinidine sulfate is the prototype of antiarrhythmicdrugs and a class IA antiarrhythmic agent according to theVaughan Williams classification. It reduces Na+ current bybinding the open ion channels (i.e., state A). The decreasedNa+entry into the myocardial cell depresses phase 4 diastolicdepolarization and shifts the intracellular threshold potentialtoward zero. These combined actions diminish thespontaneous frequency of pacemaker tissues, depress theautomaticity of ectopic foci, and, to a lesser extent, reduceimpulse formation in the SA node. This last action results inbradycardia. During the spike action potential, quinidinesulfate decreases transmembrane permeability to passiveinflux of Na+, thus slowing the process of phase 0 depolarization,which decreases conduction velocity. This is shownas a prolongation of the QRS complex of electrocardiograms.Quinidine sulfate also prolongs action potential duration,which results in a proportionate increase in the QTinterval. It is used to treat supraventricular and ventricularectopic arrhythmias, such as atrial and ventricular prematurebeats, atrial and ventricular tachycardia, atrial flutter, andatrial fibrillation.
Quinidine sulfate dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12527 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9271 | 58 |
View Lastest Price from Quinidine sulfate dihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-28 | Quinidine sulfate dihydrate
6591-63-5
|
US $60.00 / kg | 1kg | 99% | 1000 | hebei hongtan Biotechnology Co., Ltd | |
 |
2023-11-30 | Quinidine sulfate dihydrate
6591-63-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | Quinidine sulfate dihydrate
6591-63-5
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Quinidine sulfate dihydrate
6591-63-5
- US $60.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- Quinidine sulfate dihydrate
6591-63-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Quinidine sulfate dihydrate
6591-63-5
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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