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Quinidine sulfate dihydrate

Quinidine sulfate dihydrate 구조식 이미지
카스 번호:
6591-63-5
상품명:
Quinidine sulfate dihydrate
동의어(영문):
Quinidin;Unii-J13S2394he;QUINIDINE SULFATE;QUINIDINE SULFATE 99+%;Quinidine sulfate hydrate;Quinidine sulphate hydrate;Quinidine Sulfate (500 mg);QUINIDINE SULFATE DIHYDRATE;Quinidine sulfate dehydrate;QUINIDINE SULPHATE DIHYDRATE
CBNumber:
CB2471189
분자식:
2C20H24N2O2.2H2O.H2O4S
포뮬러 무게:
782.95
MOL 파일:
6591-63-5.mol

Quinidine sulfate dihydrate 속성

녹는점
212-214 °C (dec.)(lit.)
알파
[α]D20 +260~+270° (c=5, dil. HCl.10min)
굴절률
275 ° (C=2, 0.1mol/L HCl)
용해도
Slightly soluble in water, soluble in boiling water and in ethanol (96 per cent), practically insoluble in acetone.
물리적 상태
neat
수용성
Soluble in chloroform, water (11 mg/ml at 20°C), alcohol, and ethanol (50 mg/ml).
감도
Light Sensitive
Merck
14,8060
CAS 데이터베이스
6591-63-5(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-20/21/22
안전지침서 13-36
유엔번호(UN No.) UN 2811 6.1/PG III
WGK 독일 3
RTECS 번호 VA5605000
TSCA Yes
위험 등급 6.1
포장분류 III
HS 번호 2939200050
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P330 입을 씻어내시오.

Quinidine sulfate dihydrate C화학적 특성, 용도, 생산

화학적 성질

Quinidine sulfate dihydrate is white to light yellow crystal powde

용도

antiarrhythmic, antimalarial

상표명

Cin-Quin (Solvay Pharmaceuticals); Quinidex (Wyeth); Quinora (Schering).

일반 설명

Quinidine sulfate dihydrate is the sulfateof an alkaloid obtained from various species ofCinchona and their hybrids. It is a dextrorotatory diastereoisomerof quinine. The salt crystallizes from wateras the dihydrate, in the form of fine, needlelike, white crystals.Quinidine sulfate contains a hydroxymethyl groupthat serves as a link between a quinoline ring and a quinuclidinemoiety. The structure contains two basic nitrogens,of which the quinuclidine nitrogen is the stronger base(pKa 10). Quinidine sulfate dihydrate is bitter and light sensitive.Quinidine sulfate dihydrates are nearly neutral or slightly alkaline. Itis soluble to the extent of 1% in water and more highly solublein alcohol or chloroform.

Clinical Use

Quinidine sulfate is the prototype of antiarrhythmicdrugs and a class IA antiarrhythmic agent according to theVaughan Williams classification. It reduces Na+ current bybinding the open ion channels (i.e., state A). The decreasedNa+entry into the myocardial cell depresses phase 4 diastolicdepolarization and shifts the intracellular threshold potentialtoward zero. These combined actions diminish thespontaneous frequency of pacemaker tissues, depress theautomaticity of ectopic foci, and, to a lesser extent, reduceimpulse formation in the SA node. This last action results inbradycardia. During the spike action potential, quinidinesulfate decreases transmembrane permeability to passiveinflux of Na+, thus slowing the process of phase 0 depolarization,which decreases conduction velocity. This is shownas a prolongation of the QRS complex of electrocardiograms.Quinidine sulfate also prolongs action potential duration,which results in a proportionate increase in the QTinterval. It is used to treat supraventricular and ventricularectopic arrhythmias, such as atrial and ventricular prematurebeats, atrial and ventricular tachycardia, atrial flutter, andatrial fibrillation.

Quinidine sulfate dihydrate 준비 용품 및 원자재

원자재

준비 용품


Quinidine sulfate dihydrate 공급 업체

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