ZG-10
- CAS No.
- 1408077-04-2
- Chemical Name:
- ZG-10
- Synonyms
- ZG-10;Benzamide, 4-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-
- CBNumber:
- CB25984143
- Molecular Formula:
- C28H27N7O2
- Molecular Weight:
- 493.56
- MDL Number:
- MOL File:
- 1408077-04-2.mol
ZG-10 Chemical Properties,Uses,Production
Description
ZG-10 is a JNK1 inhibitor, which targets JNK and p38 signaling.
Uses
ZG-10 (JNK-IN-2) is a JNK inhibitor, with IC50 values of 809 nM, 1140 nM and 709 nM for JNK1, JNK2, and JNK3, respectively. ZG-10 (JNK-IN-2) is a potential anti-SARS-CoV-2 agent[1][2].
Definition
ChEBI: 4-[[4-(dimethylamino)-1-oxobut-2-enyl]amino]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide is a member of benzamides.
IC 50
JNK1: 809 nM (IC50); JNK2: 1140 nM (IC50); JNK3: 709 nM (IC50)
References
[1] Tinghu Zhang, et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. DOI:10.1016/j.chembiol.2011.11.010
[2] Rui Zhang, et al. Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium. Bioengineered. 2022 Feb;13(2):2486-2497. DOI:10.1080/21655979.2021.2014621
ZG-10 Preparation Products And Raw materials
Raw materials
Preparation Products
ZG-10 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4989 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 18100677375 | sales@szzxbio.com | China | 2993 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
