I-SAP
- CAS No.
- 133538-58-6
- Chemical Name:
- I-SAP
- Synonyms
- I-SAP;I SAP,ISAP;THROMBOXANE A2;SZNMERGTFJHNSM-JAWYFFTGSA-N;IODOPHENYL SULFONYL AMINO PINANE;7-(6,6-dimethyl-3-(4-iodobenzenesulfonylamino)bicyclo(3.1.1.)hept-2-yl)-5-heptenoic acid;5-Heptenoic acid, 7-[(1S,2S,3S,5R)-3-[[(4-iodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-, (5Z)-;[3S-[1alpha,3beta-5alpha]]-7-[3-[[(4-Ifodophenyl)sulfonyl]amino]-6,6-dimethylbicyclo[3.1.1]hept-2-yl]-5Z-heptenoic acid;[3S-[1ALPHA,2ALPHA,3BETA-5ALPHA]]-7-[3-[[(4-IODOPHENYL)SULFONYL]AMINO]-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2-YL]-5Z-HEPTENOIC ACID
- CBNumber:
- CB2736538
- Molecular Formula:
- C22H30INO4S
- Molecular Weight:
- 531.45
- MDL Number:
- MFCD00216083
- MOL File:
- 133538-58-6.mol
| Product description | Number | Pack Size | Price |
| I-SAP ≥98% | 19021 | 100μg | $73 |
| I-SAP ≥98% | 19021 | 500μg | $324 |
| I-SAP ≥98% | 19021 | 1mg | $575 |
| I-SAP | 1803AH | 1mg | $737 |
| [3S-[1ALPHA,3BETA-5ALPHA]]-7-[3-[[(4-IODOPHENYL)SULFONYL]AMINO]-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2-YL]-5Z-HEPTENOIC ACID 98.00% | CHM0290099 | 1MG | $1097.25 |
| Boiling point | 606.3±61.0 °C(Predicted) |
|---|---|
| Density | 1.51±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: >50 mg/ml (from Pinane TXA2); DMSO: >25 mg/ml (from Pinane TXA2); Ethanol: >100 mg/ml (from Pinane TXA2); PBS pH 7.2: >100 μg/ml (from Pinane TXA2) |
| pka | 4.76±0.10(Predicted) |
| FDA UNII | 4C2A5G825S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() ![]() GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
I-SAP price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19021 | I-SAP ≥98% | 133538-58-6 | 100μg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 19021 | I-SAP ≥98% | 133538-58-6 | 500μg | $324 | 2024-03-01 | Buy |
| Cayman Chemical | 19021 | I-SAP ≥98% | 133538-58-6 | 1mg | $575 | 2024-03-01 | Buy |
| AK Scientific | 1803AH | I-SAP | 133538-58-6 | 1mg | $737 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0290099 | [3S-[1ALPHA,3BETA-5ALPHA]]-7-[3-[[(4-IODOPHENYL)SULFONYL]AMINO]-6,6-DIMETHYLBICYCLO[3.1.1]HEPT-2-YL]-5Z-HEPTENOIC ACID 98.00% | 133538-58-6 | 1MG | $1097.25 | 2021-12-16 | Buy |
I-SAP Chemical Properties,Uses,Production
Uses
I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC)[1][2].
IC 50
TXA2 Receptor
References
[1] Saussy DL Jr, et al. Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes. Eicosanoids. 1992;5(1):1-4. PMID:1419073
[2] Schr?r K, et al. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30;49(7):921-7. DOI:10.1016/0006-2952(95)00015-r
I-SAP Preparation Products And Raw materials
Raw materials
Preparation Products
I-SAP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Guangzhou Biopark Technology Co., Ltd. | 020-83808789 | CHINA | 179 | 58 | |
| Chongqing Boer Biotechnology Co., Ltd. | 13251428727, 13368356747 | CHINA | 157 | 58 |







