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PEROSPIRONE

PEROSPIRONE
PEROSPIRONE structure
CAS No.
150915-41-6
Chemical Name:
PEROSPIRONE
Synonyms
PEROSPIRONE;Perospirine;PEROSPIRONE HCL;[14C]-Perospirone;cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide;(1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide;1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-;(3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione;(3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione;(3aS,7aR)-2-[4-[4-(1,2-Benzothiazol-3-Yl)Piperazin-1-Yl]Butyl]-3a,4,5,6,7,7a-Hexahydroisoindole-1,3-Dione
CBNumber:
CB3101658
Molecular Formula:
C23H30N4O2S
Formula Weight:
426.57
MOL File:
150915-41-6.mol

PEROSPIRONE Properties

FDA UNII
N303OK87DT

PEROSPIRONE Chemical Properties,Uses,Production

Description

Perospirone hydrochloride was launched in Japan as a new treatment of schizophrenia and other psychoses. This structurally-related analog of ziprasidone can be classically prepared by alkylation of 1-(3-benzisothiazolyl)-piperazine with the appropriate N- (chlorobutyl)-succinimide. As a result of an in vitro determination of its binding profile, perospirone demonstrated a high affinity for 5-HT2, 5-HT1A and D2 receptors as well as a significant but lower affinity for DI and al receptors. Interestingly, these differential effects on neurotransmitters with a high in vivo occupancy of 5-HT2A receptors with lower D2 occupancy seems to provide this new agent with a significantly lower propensity for the development of extrapyramidal symptoms (EPS) and tardive schizophrenia, the main sideeffects associated with classical antipsychotic therapy. Furthermore, perospirone exhibited anxiolytic-like effects in animal models. A long-term clinical trial (> 6 months) in a group of patients suffering from schizophrenia demonstrated the efficacy of perospirone over placebo for the treatment of the positive, negative and general symptoms of schizophrenia at doses of 12 mg to 96 mg t.i.d.

Originator

Sumitomo Pharm. (Japan)

brand name

Lullan

PEROSPIRONE Preparation Products And Raw materials

Raw materials

Preparation Products


PEROSPIRONE Suppliers

Global( 21)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
contact@trustwe.com CHINA 10239 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132149 58
Wuxi MinHua Biochem Pharmatech Co.,Ltd. 13961776301 0510-66903969
0510-66903969 mrweizhihua@sina.com China 38 58
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
001-617-206-9595 sales@chemreagents.com United States 9918 62
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1938 70
T&W GROUP 021-61551413-
+86 21-50676805 contact@trustwe.com;contact@trustwe.com China 9701 58
Pharmacodia (Beijing) Co.,Ltd +86-400-851-9921
+86-10-82826195 sales@pharmacodia.com China 2320 55
ShangHai Biochempartner Co.,Ltd 13720134139
candy@biochempartner.com China 7999 62
Novachemistry +44 (0)208 191 7890
+44 (0)203 637 6965 info@novachemistry.com United Kingdom 3795 58
Shanghai Luofa Biochemical Technology Co., Ltd. 021-51111890-
sales@molnova.com China 9328 58

150915-41-6(PEROSPIRONE)Related Search:


  • PEROSPIRONE
  • PEROSPIRONE HCL
  • Perospirine
  • 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-rel- (9CI)
  • 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-
  • cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide
  • (1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide
  • (3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione
  • (3aS,7aR)-2-[4-[4-(1,2-Benzothiazol-3-Yl)Piperazin-1-Yl]Butyl]-3a,4,5,6,7,7a-Hexahydroisoindole-1,3-Dione
  • [14C]-Perospirone
  • (3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
  • 150915-41-6
  • C23H30N4O2S
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