4-(4-Methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one
- CAS No.
- 54757-47-0
- Chemical Name:
- 4-(4-Methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one
- Synonyms
- (E)-4-(4-METHOXY-2,3,6-TRIMETHYL-PHENYL)-BUT-3-EN-2-ONE;CHEMBRDG-BB 5229800;Acitretin Impurity 2;4-(4-Methoxy-2,3,6-trimethylphenyl);4-(4-Methoxy-2,3,6-trimethylphenyl)-3-en-2-one;4-(4-Methoxy-2,3,6-trimethyphenyl)-but-3-en-2-one;4-(4-Methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one;4-(4-Methoxy-2,3,6-trimethylphenyl)-3E-buten-2-one;4-(4-methoxy-2,3,6-trimethylphenyl)-3E-butene-2-one;3-Buten-2-one, 4-(4-methoxy-2,3,6-trimethylphenyl)-
- CBNumber:
- CB3132003
- Molecular Formula:
- C14H18O2
- Molecular Weight:
- 218.29
- MDL Number:
- MFCD00449197
- MOL File:
- 54757-47-0.mol
| Melting point | 64-66 °C |
|---|---|
| Boiling point | 358.7±37.0 °C(Predicted) |
| Density | 1.006±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| InChI | InChI=1S/C14H18O2/c1-9-8-14(16-5)12(4)11(3)13(9)7-6-10(2)15/h6-8H,1-5H3 |
| InChIKey | NMRRLIHKRCVLLQ-UHFFFAOYSA-N |
| SMILES | CC(=O)C=CC1=C(C)C=C(OC)C(C)=C1C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
4-(4-Methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 7959AB | 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one 98%(GC) | 54757-47-0 | 1g | $16 | 2026-06-04 | Buy |
| AK Scientific | 7959AB | 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one 98%(GC) | 54757-47-0 | 5g | $52 | 2026-06-04 | Buy |
| AK Scientific | 7959AB | 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one 98%(GC) | 54757-47-0 | 25g | $249 | 2026-06-04 | Buy |
| Synthonix | M57807 | 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one 97% | 54757-47-0 | 250mg | $55.8 | 2026-05-06 | Buy |
| Synthonix | M57807 | 4-(4-Methoxy-2,3,6-trimethylphenyl)but-3-en-2-one 97% | 54757-47-0 | 1g | $60 | 2026-05-06 | Buy |
4-(4-Methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one Chemical Properties, Uses, Production
Uses
4-(4-Methoxy-2,3,6-trimethylphenyl)-3E-buten-2-one is a ketone derivative that can be used as a pharmaceutical intermediate.
Synthesis
54344-92-2
67-64-1
54757-47-0
General procedure for the synthesis of 4-(4-methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one from 4-methoxy-2,3,6-trimethylbenzaldehyde and acetone: Acetone (6000 mL) was added to 4-methoxy-2,3,6-trimethylbenzaldehyde (500.3 g) and the mixture was stirred at 20-30 °C. An aqueous sodium hydroxide solution (134.8 g NaOH dissolved in 500 mL of water) was added gradually and the reaction mixture was heated to 45-50 °C with continuous stirring. The progress of the reaction was monitored by HPLC and upon completion of the reaction, the reaction mixture was cooled and the pH was adjusted with acetic acid to 4.5-5.5. Subsequently, acetone was removed by distillation, cyclohexane was added to the residue, the organic layer was washed with water, the organic layer was separated and concentrated to afford the target product, 4-(4-methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one (Formula II). Yield: 80-84%.
References
[1] Pharmaceutical Research, 1995, vol. 12, # 7, p. 983 - 992
[2] Patent: WO2016/42573, 2016, A1. Location in patent: Page/Page column 8
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2010, vol. 185, # 3, p. 501 - 508
4-(4-Methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one Preparation Products And Raw materials
4-(4-Methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5854 | 50 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Wuhan FengyaoTonghui Chemical Products Co., Ltd. | 027-87466105 15377573527 | 2678564200@qq.com | China | 17968 | 58 |
| Henan Alfachem Co.,Ltd. | 0371-55051623 18137891487 | 3983243027@qq.com | China | 9995 | 58 |
| Nanjing crow LuNing pharmaceutical technology co., LTD | 13382066392 | CHINA | 4851 | 58 | |
| Zhengzhou Acme Chemical Co., Ltd. | 037163312495 13303845143 | 1416159398@qq.com | China | 10141 | 58 |
| Shenzhen Botel Biotechnology Co. Ltd. | 13316949107 13316968096 | 1979313431@qq.com | China | 9622 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29086 | 58 |
View Latest Price from 4-(4-Methoxy-2,3,6-trimethylphenyl)-but-3-en-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
54757-47-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-08-08 | 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
54757-47-0
|
$3.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
54757-47-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-BUT-3-EN-2-ONE
54757-47-0
- $3.00
- 99%
- Career Henan Chemical Co
