violacein
- CAS No.
- 548-54-9
- Chemical Name:
- violacein
- Synonyms
- Anorosin;violacein;Brn 0049923;Violacein from Janthinobacterium lividum;3-(2-(5-Hydroxyindol-3-yl)-5-oxo-2-pyrrolin-4-ylidene)-2-indolinone;2-Indolinone, 3-(2-(5-hydroxyindol-3-yl)-5-oxo-2-pyrrolin-4-ylidene)-;Oxindole, 3-(2-(5-hydroxyindol-3-yl)-5-oxo-2-pyrrolin-4-ylidene)- (6ci);3-[2-(5-Hydroxy-1H-indol-3-yl)-5-oxo-2-pyrrolin-4-ylidene]-2-indolinone;3-[2-(5-Hydroxy-1H-indol-3-yl)-5-oxo-2-pyrrolin-4-ylidene]-1,3-dihydro-2H-indol-2-one;3-[5-(5-Hydroxy-1H-indole-3-yl)-2,3-dihydro-2-oxo-1H-pyrrole-3-ylidene]-1H-indole-2(2H)-one
- CBNumber:
- CB31385284
- Molecular Formula:
- C20H13N3O3
- Molecular Weight:
- 343.34
- MDL Number:
- MFCD01718468
- MOL File:
- 548-54-9.mol
- MSDS File:
- SDS
| Melting point | >350 °C (decomp) |
|---|---|
| Boiling point | 821.4±65.0 °C(Predicted) |
| Density | 1.549±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: insoluble |
| form | A solid |
| pka | 9.72±0.40(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | QJH0DSQ3SG |
violacein price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V9389 | Violacein from Janthinobacterium lividum >98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC) | 548-54-9 | 1mg | $440 | 2024-03-01 | Buy |
| Cayman Chemical | 27959 | Violacein | 548-54-9 | 1mg | $295 | 2024-03-01 | Buy |
| TRC | V634450 | Violacein | 548-54-9 | 2.5mg | $160 | 2021-12-16 | Buy |
| TRC | V634450 | Violacein | 548-54-9 | 25mg | $1260 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0016233 | VIOLACEIN 95.00% | 548-54-9 | 5MG | $498.64 | 2021-12-16 | Buy |
violacein Chemical Properties,Uses,Production
Description
Violacein is a naturally occurring di-indole-pyrrole violet-blue colored pigment that possesses numerous biological functions such as antimicrobial, antiviral, anticancer, antiulcerogenic, anti-leishmanial, and enzyme modulation properties (Narsing et al. 2017). Violacein is biosynthesized by bacterial species such as Chromobacterium violaceum, Collimonas sp., Pseudoalteromonas sp., Pseudomonas aeruginosa, and Janthinobacterium sp. This natural pigment is used extensively in the cosmetic, food, pharmaceutical, and textile industries (Baiano 2014).
Uses
Violacein is an intense violet pigment formed by the condensation of two tryptophan units, found in a number of bacteria, notably Chromobacterium violaceum. The regulation of pigment biosynthesis is the chromogenic basis for the use of C. violaceum CV26 for the detection of quorum sensing mediators. Violacein exhibits broad spectrum actvity against bacteria, protozoans (including malaria), viruses and mammalian cell lines. Violacein cell toxicity resembles TNF-α signal transduction.
Uses
Violacein is tryptpphan-derived pigment produced by environmental bacterial. Violacein inhibits gram-positive pathogens by tearing off cytoplasmic cells as observed in Bacillus subtilis and Staphylococcus aureus cells using fluorescence microscopy.
Uses
Violacein from Janthinobacterium lividum has been used:
for cell culture assays
as a standard to determine the crude violacein concentration in ethanol extracts of D. violaceinigra str. NI28 cultures
as a standard to identify violacein in the leaf samples of Nicotiana
Definition
ChEBI: violacein is a member of the class of hydroxyindoles resulting from the formal oxidative coupling between the 3-position of 1,3-dihydro-2H-indol-2-one and the 3-position of 1,3-dihydro-2H-pyrrol-2-one, which is substituted at the 5 position by a 5-hydroxy-1H-indol-3-yl group, where the newly-formed double bond has E configuration. It is a purple chromobacterial pigment that has antibacterial, antifungal, antiprotozoan, and anticancer properties.
General Description
Violacein from Janthinobacterium lividum is used as a colorant for natural and synthetic fabrics. It functions as a respiratory pigment and regulates tryptophan production. Violacein exhibits anti-protozoal activity.
Biochem/physiol Actions
Violacein, a violet pigment, is an indole derivative produced by various bacterial strains such as Chromobacterium violaceum, Janthinobacterium lividum, Chromobacterium lividum, and Pseudoalteromonas luteoviolacea. Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities. Violacein and its β-cyclodextrin complexes trigger apoptosis and differentiation in HL60 leukemic cells. Violacein cytotoxicity is preceded by activation of caspase 8, transcription of NF-κB target genes, and p38-MAPK activation resembling TNF-α signal transduction.
violacein Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |