ChemicalBook >> CAS DataBase List >>1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE structure

CAS No.: 168986-60-5

Chemical Name:: 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

Synonyms: RS67333HCl;RS 67333 hydrochlori;RS 67333 HYDROCHLORIDE;RS 67333 hydrochloride >=98% (HPLC);1-(4-AMino-5-chloro-2-Methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride;1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE;1-Propanone, 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-, hydrochloride (1:1)

CBNumber:: CB3187740

Molecular Formula:: C19H30Cl2N2O2

Molecular Weight:: 389.36

MDL Number:: MFCD00938576

MOL File:: 168986-60-5.mol

Last updated:2023-09-04 15:51:00

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1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Properties

storage temp.	Store at RT
form	Powder
Water Solubility	Soluble to 25 mM in water with gentle warming

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1882	RS 67333 hydrochloride ≥98% (HPLC)	168986-60-5	5MG	$105	2024-03-01	Buy
Sigma-Aldrich	SML1882	RS 67333 hydrochloride ≥98% (HPLC)	168986-60-5	25MG	$424	2024-03-01	Buy
TRC	R701025	RS67333Hydrochloride	168986-60-5	50mg	$610	2021-12-16	Buy
ApexBio Technology	B5041	1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride	168986-60-5	50mg	$929	2021-12-16	Buy
American Custom Chemicals Corporation	API0006965	RS -67333 95.00%	168986-60-5	5MG	$504.82	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML1882	5MG	$105	Buy
SML1882	25MG	$424	Buy
R701025	50mg	$610	Buy
B5041	50mg	$929	Buy
API0006965	5MG	$504.82	Buy

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

RS 67333 Hydrochloride is a 5-HT4 receptor agonist.

Biological Activity

A potent and highly selective 5-HT 4 partial agonist, with pK i values of 8.7 at 5-HT 4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT 1A , 1D , 2A , 2C , D 1 , D 2 and M 1-3 . Active in vivo , with an intrinsic activity relative to 5-HT of 0.5.

Biochem/physiol Actions

RS 67333 is a selective, high affinity (pKi = 8.7 for the 5-HT4 binding site in guinea-pig striatum) partial agonist toward 5-HT4 receptor that relaxes carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pEC50/%reversal = 8.7/50 with RS 67333 vs. 8.2/100 with 5-HT) and induces tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (ED50 via i.p. in μg/kg over max heart rate increase in beats/min = 4.9/35 with RS 67333 vs. 3.2/95 with 5-HT). RS 67333 is also reported to show high affinity for sigma receptors (pKi = 8.9/σ1 and 8.0/σ2), while exhibiting much reduced affinity toward a panel of other receptors, including 5-HT1A, 5-HT2A, 5-HT2C, 5-HT3 (pKi <6.4), muscarinic receptors (pKi = 5.2/M1 & 5.3/M2), and adrenoceptors (pKi <6.7 for α1A, α1B, α2A, α2B, β1, β2).

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Suppliers

Global( 47)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58
Chengdu YouSuo Biotechnology Limited	13693449011	83948782@qq.com	China	92	50
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4121	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
LETOPHARM LIMITED	58
Chengdu YouSuo Biotechnology Limited	50
Shanghai Lollane Biological Technology Co.,Ltd.	55
EMMX Biotechnology LLC	60

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Spectrum

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE(168986-60-5)¹HNMR

168986-60-5(1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE)Related Search:

Poly(hexamethylenebiguanide)hydrochloride Triethylamine hydrochloride 1-(4-Amino-2-hydroxy-phenyl)-propan-1-one 2-Chloro-5-methoxyaniline P-HEXYLANILINE HYDROCHLORIDE

1-(4-AMINO-3-CHLORO-PHENYL)-PROPAN-1-ONE 4-(3-PHENYL-PROPYL)-PIPERIDINE HCL 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE 4-aminohexanoylphenone

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1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE RS 67333 HYDROCHLORIDE RS67333HCl 1-(4-AMino-5-chloro-2-Methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride RS 67333 hydrochlori RS 67333 hydrochloride >=98% (HPLC) 1-Propanone, 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-, hydrochloride (1:1) 168986-60-5 C19H30Cl2N2O2 C19H29ClN2O2HCl