Sugammadex sodium
- CAS No.
- 343306-79-6
- Chemical Name:
- Sugammadex sodium
- Synonyms
- ORG;Sugammadex Na;Sugammadex soidum;Sugammadex sodium iMpurity;6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin Sodium Salt;6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt;CS-2749;Suga-im D;madex Sodium;Sugammadex IMP
- CBNumber:
- CB32502868
- Molecular Formula:
- C72H104Na8O48S8
- Molecular Weight:
- 2177.97
- MDL Number:
- MFCD09954145
- MOL File:
- 343306-79-6.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| solubility | DMF: 2.5 mg/ml; DMSO: 2.5 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml |
| form | A crystalline solid |
| InChIKey | NIOBYNJFPSIMJF-OBHNVPISNA-N |
| FDA UNII | ERJ6X2MXV7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H334 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P285-P304+P341-P342+P311-P501 | |||||||||
| NFPA 704 |
|
Sugammadex sodium price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3224 | Sugammadex sodium ≥95% (HPLC) | 343306-79-6 | 25MG | $109 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3224 | Sugammadex sodium ≥95% (HPLC) | 343306-79-6 | 100MG | $350 | 2024-03-01 | Buy |
| Cayman Chemical | 24096 | Sugammadex (sodium salt) ≥98% | 343306-79-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24096 | Sugammadex (sodium salt) ≥98% | 343306-79-6 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 24096 | Sugammadex (sodium salt) ≥98% | 343306-79-6 | 10mg | $243 | 2024-03-01 | Buy |
Sugammadex sodium Chemical Properties,Uses,Production
Description
To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.
Chemical Properties
White to Light yellow powder to crystal.Soluble in water, insoluble in methanol and ethanol.
Originator
Organon (Netherlands)
Uses
Sugammadex Sodium is the first in a class of drugs called selective relaxant binding agents that offers improved termination of the paralytic effects of neuromuscular blocking agents and may have many potential peri-operative benefits.
Application
Sugammadex sodium is a modified γ-cyclodextrin. It is a selective relaxant binding agent (SRBA) indicated for reversal of neuromuscular block induced by steroid-based muscle relaxants, such as rocuronium bromide and vecuronium bromide. Sugammadex soium forms a complex with the muscle relaxants, and it reduces the amount of them available to bind to nicotinic cholinergic receptors in the neuromuscular junction.
Definition
ChEBI: Sugammadex sodium is an organic sodium salt that is the octasodium salt of sugammadex. Used for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery. It has a role as a neuromuscular agent. It contains a sugammadex(8-).
brand name
Bridion
Side effects
The most common adverse effects included coughing, movement, vomiting, dry mouth, dysgeusia, hypotension, parosmia, and a sensation of changed temperature.Sugammadex is recommended for the reversal of neuromuscular blockade induced by rocuronium or vecuronium; it should not be used with other steroidal blocking agents since safety and efficacy data are not available for these situations. It should also not be partnered with non-steroidal neuromuscular blockers such as succinylcholine or benzylisoquinolinium-based drugs. Since sugammadex is predominantly cleared by the kidneys, care should be taken when administering this reversal agent in patients with renal impairment.
Mode of action
Sugammadex Sodium is the sodium salt form of sugammadex, a biologically inert, selective relaxant binding agent (SRBA) composed of a modified, anionic gamma cyclodextrin derivative containing a hydrophilic exterior and a hydrophobic core, with neuromuscular blocking drug (NMBD) reversal activity. Upon administration, the negatively charged carboxyl-thio-ether groups of sugammadex selectively and reversibly bind to the positively charged quaternary nitrogen of a steroidal NMBD, such as rocuronium and vecuronium, which was administered at an earlier time for anesthetic purposes. The encapsulation of the NMBD by sugammadex blocks its ability to bind to nicotinic receptors in the neuromuscular junction and thereby reverses the NMBD-induced neuromuscular blockade.
Sugammadex sodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| Biopole Pharmatech Co., Ltd. | +8615151475053 | biopole@163.com | China | 37 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1100 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
Related articles
- Efficacy and safety of sugammadex sodium in reversing rocuronium-induced neuromuscular blockade in children: An updated
- Sugammadex sodium is is more effective and safer in reversing rocuronium-induced neuromuscular blockade in children than tradi....
- Jan 26，2024
View Lastest Price from Sugammadex sodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Sugammadex sodium
343306-79-6
|
US $0.00-0.00 / KG | 5KG | 0.99 | 50MT/month | Hebei Yanxi Chemical Co., Ltd. | |
 |
2024-04-22 | Sugammadex sodium
343306-79-6
|
US $0.00 / KG | 2KG | 99% up, High Density | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-03-28 | Sugammadex sodium
343306-79-6
|
US $0.00 / KG | 25KG | 98% | Inquiry | PNP Biotech Co. Ltd |
-
- Sugammadex sodium
343306-79-6
- US $0.00-0.00 / KG
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Sugammadex sodium
343306-79-6
- US $0.00 / KG
- 99% up, High Density
- Sinoway Industrial co., ltd.
-
- Sugammadex sodium
343306-79-6
- US $0.00 / KG
- 98%
- PNP Biotech Co. Ltd
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