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(R,R,R)-Aprepitant

(R,R,R)-Aprepitant Structure
(R,R,R)-Aprepitant structure
CAS No.
1148113-53-4
Chemical Name:
(R,R,R)-Aprepitant
Synonyms
Aprepitant A;(R,R,R)-Aprepitant;(1R,2R,3R)-Aprepitant;"1R,2R,2R Aprepitant";Aprepitant impurity 04;Aprepitant EP Impurity E;Aprepitant Related CoMpound A;Aprepitant trans-1-enantiomer;Aprepitant USP RC A (R,R,R-Diasteromer);Aprepitant EP Impurity E/ (R,R,R)-Aprepitant
CBNumber:
CB32557888
Molecular Formula:
C23H21F7N4O3
Molecular Weight:
534.43
MDL Number:
MFCD23704633
MOL File:
1148113-53-4.mol
Last updated:2023-05-04 15:14:49
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(R,R,R)-Aprepitant Properties

Density 1.51±0.1 g/cm3(Predicted)
pka 8.06±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H413-H302
Precautionary statements  P264-P270-P301+P312-P330-P501
HS Code  2934990002

(R,R,R)-Aprepitant price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1041915 Aprepitant Related Compound A United States Pharmacopeia (USP) Reference Standard 1148113-53-4 10MG $1300 2024-03-01 Buy
TRC A729785 (R,R,R)-Aprepitant 1148113-53-4 25mg $5095 2021-12-16 Buy
American Custom Chemicals Corporation API0027120 APREPITANT RELATED COMPOUND A 95.00% 1148113-53-4 5MG $504.12 2021-12-16 Buy
AK Scientific 6464EM (R,R,R)-Aprepitant 1148113-53-4 2mg $590 2021-12-16 Buy
Product number Packaging Price Buy
1041915 10MG $1300 Buy
A729785 25mg $5095 Buy
API0027120 5MG $504.12 Buy
6464EM 2mg $590 Buy

(R,R,R)-Aprepitant Chemical Properties,Uses,Production

Uses

(R,R,R)-Aprepitant (Aprepitant EP Impurity E) is the (R,R,R)-enantiomer of Aprepitant (A729800), the key intermediate of Aprepitant in bulk drug and formulation samples of Aprepitant.

(R,R,R)-Aprepitant synthesis

252742-72-6
380499-06-9
1148113-53-4
Synthesis of (R,R,R)-Aprepitant from 5-Chloromethyl-2H-1,2,4-triazolin-3-one and (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine

(R,R,R)-Aprepitant Preparation Products And Raw materials

Raw materials

(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine 5-Chloromethyl-2H-1,2,4-triazolin-3-one

Preparation Products

(R,R,R)-Aprepitant Suppliers

Global( 70)Suppliers
Supplier Tel Email Country ProdList Advantage
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9702 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
CR Corporation Lomited 		fred.wen@crcorporation.cn CHINA 12069 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12382 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Adamas Reagent, Ltd. 400-6009262 16621234537 zhangsn@titansci.com China 14113 59
Supplier Advantage
Finetech Industry Limited
58
Hubei Jusheng Technology Co.,Ltd. 		58
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
CR Corporation Lomited 		58
sgtlifesciences pvt ltd 		58
LEAP CHEM CO., LTD. 		58
China National Standard Pharmaceutical Corporation Limited 		58
Amadis Chemical Company Limited 		58
Adamas Reagent, Ltd. 59

1148113-53-4((R,R,R)-Aprepitant)Related Search:

Aprepitant Aprepitant Atorvastatin Related Compound D (20 mg) (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2- carboxylic acid phenylamide) Atorvastatin Ethyl Ester Atorvastatin Related Compound C
Atorvastatin Methyl Ester Atorvastatin Epoxy Tetrahydrofuran IMpurity Atorvastatin Acetonide Atenolol 2-[4-(2,3-DIHYDROXYPROPOXY)PHENYL]ACETAMIDE
Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide Atorvastatin tert-Butyl Ester 2,3-Dehydroxy Atorvastatin Sodium Salt 3S,5R isoMer, or (3S,5R)-7-[3-(phenylcarbaMoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt O-Methyl Atorvastatin Calcium Salt
5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one Aprepitant Impurity 11 HCl Aprepitant Impurity 2

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(R,R,R)-Aprepitant Aprepitant Related Compound A (10 mg) (3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one) 5-[[(2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-Morpholinyl]Methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one Aprepitant Related CoMpound A Aprepitant EP Impurity E Aprepitant A Aprepitant USP RC A (R,R,R-Diasteromer) Aprepitant trans-1-enantiomer (1R,2R,3R)-Aprepitant 3-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one Aprepitant impurity 5/Aprepitant EP Impurity E Aripitant related substance A reference substance 3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro- 5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one Aprepitant EP Impurity E/ (R,R,R)-Aprepitant "1R,2R,2R Aprepitant" Aprepitant Related Compound A (3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fl (1041915) Aprepitant(R,R,R)-Isomer（Azilsartan Impurity 41） Aprepitant impurity 04 Aprepitant RRR isomer (diastearomer)-(5-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl) ethoxy)-3-(4-fluorophenyl) morpholino)methyl)-1,2-dihydro-1,2,4-triazol-3-one) 1148113-53-4 Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals