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Guanine

Organic bases 6-Thioguanine Chemical Properties Uses Production method
Guanine
Guanine structure
CAS No.
73-40-5
Chemical Name:
Guanine
Synonyms
Gua;Guanin;Guanie;GUANINE;ci75170;guamine;quanine;dewpearl;Dew Pearl;c.i.75170
CBNumber:
CB3259805
Molecular Formula:
C5H5N5O
Formula Weight:
151.13
MOL File:
73-40-5.mol

Guanine Properties

Melting point:
>300 °C(lit.)
Boiling point:
273.11°C (rough estimate)
Density 
1.4456 (rough estimate)
refractive index 
2.0000 (estimate)
storage temp. 
2-8°C
solubility 
1 M NaOH: 0.1 M at 20 °C, clear, colorless
Density
2.19±0.1 g/cm3(Predicted)
Melting Point
360 °C (decomp)
form 
Powder
pka
9.92(at 40℃)
color 
White to cream
Water Solubility 
practically insoluble
Merck 
14,4564
BRN 
9680
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
UYTPUPDQBNUYGX-UHFFFAOYSA-N
CAS DataBase Reference
73-40-5(CAS DataBase Reference)
NIST Chemistry Reference
6H-Purin-6-one, 2-amino-1,7-dihydro-(73-40-5)
EPA Substance Registry System
6H-Purin-6-one, 2-amino-1,7-dihydro-(73-40-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P305+P351+P338-P261-P280a-P304+P340-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  MF8260000
Hazard Note  Irritant
TSCA  Yes
HS Code  29335990

Guanine price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich G11950 Guanine 98% 73-40-5 10g $22.3 2018-11-13 Buy
Sigma-Aldrich 1302156 Guanine United States Pharmacopeia (USP) Reference Standard 73-40-5 100mg $394 2018-11-13 Buy
TCI Chemical G0169 Guanine >98.0%(T)(HPLC) 73-40-5 1g $14 2018-11-22 Buy
TCI Chemical G0169 Guanine >98.0%(T)(HPLC) 73-40-5 25g $32 2018-11-22 Buy
Alfa Aesar A12024 Guanine, 98% 73-40-5 25g $22.5 2018-11-13 Buy

Guanine Chemical Properties,Uses,Production

Organic bases

Guanine is an organic base that is widespread in the animal and the plant kingdom. The chemical name is 2-amino-6-oxo-purin. It is colorless square crystals or crystalline powder. In the aqueous solution containing a large excess of ammonia, it will become small diamond crystal after slowly evaporating the water. It has a melting point of 360 ℃ (partially decomposed and sublimated). It can be dissolved in ammonia water, caustic soda and dilute mineral acid, slightly soluble in ethanol, ethyl ether, and insoluble in water. It has a strong UV absorption. It is the major composition of guanosine and guanylate. Its hydrochloride monohydrate is powdery crystals with water being loss at 100 ℃ and hydrogen chloride being loss at 200 ℃. It can be dissolved in acidified water but is insoluble in water, alcohol, and ether. Guanine can be obtained through the hydrolysis of scale in hydrochloric acid. It is an important base composition of nucleic acids, being one of the four major bases of DNA and RNA as well as the compassion of various kinds of guanylate. Its N9 can be connected with the C1 of ribose or deoxyribose with β-glycosidic bond to obtain guanosine or deoxy-guanosine.
[Major application]: for biochemical research and preparation of caffeine and other drugs.
Its chemical composition is 2-amino-6-mercaptopurine. It, together with adenine, constitutes the two major purines bases in the nucleic acid. Through binding to ribose guanosine or deoxyribose guanosine through the glycosidic linkages, the corresponding triphosphates are guanosine triphosphate or deoxyguanosine triphosphate, respectively. They are the precursor of guanine during the biosynthesis process of RNA and DNA.

6-Thioguanine

6-Thioguanine belongs to another kind of common purine metabolism antagonist in the inhibition of the purine synthesis pathway and is a cell cycle specific drugs to which those cells locating in the cycle S period are most sensitive. In addition to inhibit the biosynthesis of cellular DNA, it also has mild inhibitory effect on the biosynthesis of RNA. This product is a kind of guanosine analogs. It becomes active only after being converted to 6-TG ribonucleotide via the phosphor-ribosyltransferase inside human body. The action process of this product is similar to that of mercapto-purine. In addition, 6-TG ribonucleotide, through its inhibitory effect on guanylate kinase, can prevent the phosphorylation of guanosine monophosphate (GMP) into guanosine diphosphate (GDP). This product, after being metabolized into deoxyribonucleoside triphosphate, can be embedded in DNA, thus further inhibiting the biosynthesis of nucleic acids while mercaptopurine having no effect. The product has cross-resistance with mercaptopurine while it can have its efficacy improved upon combination with other drugs such as cytarabine. Its oral absorption after oral administration is incomplete, at about 30%. Only a relatively small amount of the drug can shift from the blood to penetrate through the blood-brain barrier, therefore at generally oral dose, it is insufficient to prevent and treat meningeal leukemia. The activation and decomposition process of the product both proceeds in the liver with being de-activated through either shifting the amino-methyl mercaptopurine via methylation or shifting to mercaptopurine via deamination. However, the metabolic process of inactivation is not related to xanthine oxidase, therefore taking allopurinol has no significant inhibitory effect on the metabolism of this product. The half-life of intravenous injection is 25~240 min with the average period being 80 min. Through being excreted through the kidneys, for one time of oral administration, about 40% of the drug is excreted in urine in the form of metabolites within 24h with only trace amount of 6-Thioguanine being detected in the urine.

Chemical Properties

It is colorless needle crystal or amorphous powder. The melting point is 360 ℃ (decomposition). It is easily soluble in acid and alkali, slightly soluble in alcohol, ether, but insoluble in water.
The above information is edited by the chemicalbook of Dai Xiongfeng.

Uses

It can be used for biochemical studies.
It can be used as the intermediates of the antiviral drugs acyclovir.
It can be used as the intermediate of thioguanine and open-ringed guanine.

Production method

5-amino-4-imidazolyl amide can have esterification reaction with isothiocyanate methylbenzene to generate ester, and then successfully reacted with methyl iodide, ammonia to synthesize it.

Chemical Properties

white to light yellow crystal powder

History

Guanine is one of the two purines comprising the five nucleic acid bases. Much of the information regarding the general role of nucleic acid bases is covered in Adenine and Cytosine. Guanine gets its name from guano, from which it was first isolated in the 1840s. Albrecht Kossel (1853 1927) determined that guanine (as well as adenine, cytosine, thymine and uracil) was a component of nucleic acid in the last two decades of the 19th century. Similar to adenine, guanine combines with ribose to form a nucleoside. The nucleoside produced is guanosine, which in turn combines with one to three phosphoryls to yield the nucleotides guanosine monophosphate (GMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP), respectively. Guanine nucleotides play an important role in metabolism including the conversion of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) and carbohydrate metabolism.

Uses

Guanine is a crystalline amorphous substance that is found in guano, fish scales, and theliver of certain mammals. Guanine is responsible for the silvery iridescence of certain fishscales. Before its discovery, guanine was scraped from fish scales and used to coat beads to produceimitation pearls. Thus it was called pearl essence or pearly white in the 1700s. Guanineobtained from fish scales is used in cosmetics, especially for eye cosmetics and nail polishes.

Uses

Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.

Uses

guanine is mixed in water and used primarily in nail polish to achieve a pearlized effect. It has been greatly replaced by either synthetic pearl or aluminum and bronze particles. guanine is obtained from plant or animal sources.

Definition

A nitrogenous base found in DNA and RNA. Guanine has a purine ring structure.

Definition

guanine: A purine derivative. It isone of the major component bases ofnucleotides and the nucleic acidsDNA and RNA.

Definition

ChEBI: A 2-aminopurine carrying a 6-oxo substituent.

Guanine Preparation Products And Raw materials

Raw materials

Preparation Products


Guanine Suppliers

Global( 449)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21671 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1016 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58

View Lastest Price from Guanine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-12 Guanine
73-40-5
US $1.00 / Kg/Drum 1KG 99% 99999tons Shandong Kangmailin Chemical Technology Co. Ltd..
2018-08-07 Guanine
73-40-5
US $1.00 / KG 1KG 98% 20KG career henan chemical co
2019-04-25 Guanine
73-40-5
US $10.00 / Kg 1Kg 99% 500tons/month Hebei Chisure Biotechnology Co., Ltd.

Guanine Spectrum


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