L 656748
- CAS No.
- 121124-29-6
- Chemical Name:
- L 656748
- Synonyms
- L 656748;EMaMectin B1a;Unii-IX4GP7848F;Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)-
- CBNumber:
- CB32703722
- Molecular Formula:
- C49H75NO13
- Molecular Weight:
- 886.12
- MDL Number:
- MOL File:
- 121124-29-6.mol
- MSDS File:
- SDS
| Boiling point | 935.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C, protect from light |
| solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble |
| form | A solid |
| pka | 12.42±0.70(Predicted) |
| Stability | Light Sensitive |
| FDA UNII | IX4GP7848F |
L 656748 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24060 | Emamectin B1a ≥99% | 121124-29-6 | 1mg | $336 | 2024-03-01 | Buy |
| Cayman Chemical | 24060 | Emamectin B1a ≥99% | 121124-29-6 | 5mg | $1172 | 2024-03-01 | Buy |
| Usbiological | 448150 | Emamectin B1a | 121124-29-6 | 1mg | $779 | 2021-12-16 | Buy |
| TRC | E520505 | EmamectinB1a | 121124-29-6 | 5mg | $1000 | 2021-12-16 | Buy |
L 656748 Chemical Properties,Uses,Production
Description
Emamectin B1a is a semisynthetic derivative of avermectin B1a . It binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively), and potentiates the GABA response. Emamectin B1a also binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord). Emamectin B1a induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml, which is approximately 1,500-fold more toxic than avermectin B1. It is effective against neonate S. eridania larvae in a foliage spray bioassay and when applied topically.
Uses
Emamectin B1a is a semi-synthetic 4”-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4”-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin class. Emamectin B1a, as a benzoate salt, is the major component (>90%) of the commercial insecticide/acaricide, emamectin. Members of the avermectin/milbemycin class exert their insecticidal/anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells.
L 656748 Preparation Products And Raw materials
Raw materials
Preparation Products
L 656748 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 56039 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| ShangHai Anpel Co, Ltd. | 18501792038; 18501792038 | shanpel@anpel.com.cn | China | 9614 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.com | China | 24246 | 58 |