K-Ras(G12C) inhibitor 9
- CAS No.
- 1469337-91-4
- Chemical Name:
- K-Ras(G12C) inhibitor 9
- Synonyms
- K-RAS inhibitor 9;K-Ras(G12C) inhibitor 9;K-Ras(GI2C) Inhibitor 9;K-Ras(G12C) inhibitor 9 USP/EP/BP;K RAS INHIBITOR-9; KRAS INHIBITOR 9;N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide;Ethenesulfonamide, N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-;K-Ras(G-12C) inhibitor 9,KRas(G12C) inhibitor 9,Ras,Inhibitor,K-Ras(G12C) inhibitor 9,inhibit,K Ras(G12C) inhibitor 9
- CBNumber:
- CB32722367
- Molecular Formula:
- C16H21ClIN3O4S
- Molecular Weight:
- 513.78
- MDL Number:
- MFCD28143916
- MOL File:
- 1469337-91-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
K-Ras(G12C) inhibitor 9 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18005 | K-Ras(G12C) Inhibitor 9 ≥98% | 1469337-91-4 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18005 | K-Ras(G12C) Inhibitor 9 ≥98% | 1469337-91-4 | 5mg | $193 | 2024-03-01 | Buy |
| Cayman Chemical | 18005 | K-Ras(G12C) Inhibitor 9 ≥98% | 1469337-91-4 | 10mg | $341 | 2024-03-01 | Buy |
| Cayman Chemical | 18005 | K-Ras(G12C) Inhibitor 9 ≥98% | 1469337-91-4 | 25mg | $533 | 2024-03-01 | Buy |
| TRC | C367445 | N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide | 1469337-91-4 | 5mg | $185 | 2021-12-16 | Buy |
K-Ras(G12C) inhibitor 9 Chemical Properties,Uses,Production
Description
K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro. K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.
Uses
N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide is an allosteric inhibitor of tumor-promoting K-Ras(G12c).
in vitro
k-ras(g12c) inhibitor 9 belongs to a series of small molecules, which irreversibly compete with gtp and gdp for binding to a common oncogenic k-ras(g12c) mutant and blocked the association of b-raf and c-raf with k-ras(g12c). k-ras(g12c) inhibitor 9 (10 μm) decreased viability and increased apoptosis of g12c mutations-containing lung cancer cell lines (h1792, calu-1, h358, and h23) [1].
target
k-ras(g12c)
References
1. ostrem jm, peters u, sos ml, wells ja, shokat km. k-ras(g12c) inhibitors allosterically control gtp affinity and effector interactions. nature. 2013;503(7477):548-51. 2. hunter jc, gurbani d, ficarro sb, carrasco ma, lim sm, choi hg, et al. in situ selectivity profiling and crystal structure of sml-8-73-1, an active site inhibitor of oncogenic k-ras g12c. proc natl acad sci u s a. 2014;111(24):8895-900. 3. lim sm, westover kd, ficarro sb, harrison ra, choi hg, pacold me, et al. therapeutic targeting of oncogenic k-ras by a covalent catalytic site inhibitor. angew chem int ed engl. 2014;53(1):199-204.
K-Ras(G12C) inhibitor 9 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29067 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |