1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
- CAS No.
- 146447-18-9
- Chemical Name:
- 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
- Synonyms
- 2-Chloro-4-fluoro-5-bromoanisole;5-BROMO-2-CHLORO-4-FLUOROANISOLE;5-Bromo-2-chloro-4-fluoro-1-methoxybenzene;1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE;Benzene,1-bromo-4-chloro-2-fluoro-5-methoxy-;1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE ISO 9001：2015 REACH
- CBNumber:
- CB3443626
- Molecular Formula:
- C7H5BrClFO
- Molecular Weight:
- 239.47
- MDL Number:
- MFCD07784265
- MOL File:
- 146447-18-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-2-chloro-4-fluoroanisole >98.0%(GC) | B5354 | 200mg | $68 |
| 5-Bromo-2-chloro-4-fluoroanisole >98.0%(GC) | B5354 | 1g | $203 |
| 5-Bromo-2-chloro-4-fluoroanisole | B874608 | 100mg | $65 |
| 1-Bromo-4-chloro-2-fluoro-5-methoxybenzene 99.25% | CS-0061950 | 5g | $234 |
| 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene | X4235 | 5g | $804 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P271-P280-P312 | |||||||||
| Hazard Codes | Xn | |||||||||
| HS Code | 2909309090 | |||||||||
| NFPA 704 |
|
1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5354 | 5-Bromo-2-chloro-4-fluoroanisole >98.0%(GC) | 146447-18-9 | 200mg | $68 | 2025-07-31 | Buy |
| TCI Chemical | B5354 | 5-Bromo-2-chloro-4-fluoroanisole >98.0%(GC) | 146447-18-9 | 1g | $203 | 2025-07-31 | Buy |
| TRC | B874608 | 5-Bromo-2-chloro-4-fluoroanisole | 146447-18-9 | 100mg | $65 | 2021-12-16 | Buy |
| ChemScene | CS-0061950 | 1-Bromo-4-chloro-2-fluoro-5-methoxybenzene 99.25% | 146447-18-9 | 5g | $234 | 2021-12-16 | Buy |
| AK Scientific | X4235 | 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene | 146447-18-9 | 5g | $804 | 2021-12-16 | Buy |
1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Chemical Properties,Uses,Production
Synthesis
148254-32-4
74-88-4
146447-18-9
1. 5-bromo-2-chloro-4-fluorophenol (1.0 g, 4.4 mmol) was dissolved in N,N-dimethylformamide (DMF, 5 mL) in a dry reaction flask. 2. iodomethane (0.55 mL, 8.8 mmol) and potassium carbonate (1.2 g, 8.9 mmol) were added sequentially. 3. The reaction mixture was stirred at room temperature for 20 hours and the progress of the reaction was monitored by thin layer chromatography (TLC). 4. Upon completion of the reaction, the reaction was quenched by adding water (20 mL) to the reaction mixture. 5. The reaction mixture was extracted with ether (20 mL x 3) and the organic phases were combined. 6. The organic phase was washed with saturated saline (20 mL) and dried over anhydrous magnesium sulfate. 7. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure to obtain the crude product. 8. The crude product was further purified (if required) to give 5-bromo-2-chloro-4-fluoroanisole (0.951 g, 90% yield) as a white solid. 9. 9. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ3.88 (s, 3H), 7.07 (d, J=5.8 Hz, 1H), 7.19 (d, J=8.0 Hz, 1H) and 19F-NMR (376 MHz, CDCl3): δ-116.1 (s, 1F).
References
[1] Patent: US2016/24110, 2016, A1. Location in patent: Paragraph 0577; 0585
[2] Patent: JP2016/56157, 2016, A. Location in patent: Paragraph 0163
[3] Patent: JP2016/60742, 2016, A. Location in patent: Paragraph 0242; 0244
1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3979 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14359 | 58 |
View Lastest Price from 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-01-03 | 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene
146447-18-9
|
US $0.00-0.00 / KG | 10mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-14 | 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
146447-18-9
|
US $1.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene
146447-18-9
- US $0.00-0.00 / KG
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
146447-18-9
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
