Methyl 2,6-dichloronicotinate
- CAS No.
- 65515-28-8
- Chemical Name:
- Methyl 2,6-dichloronicotinate
- Synonyms
- Sosimerasib Impurity 2;METHYL 2,6-DICHLORONICOTINATE;2,6-two chloroMethyl nicotinate;Methyl2,6-dichloronicotinate,97%;Methyl 2,6-Dichloronicotinate >methyl 2,6-dichloronicotinate (en);METHYL 2 6-DICHLOROPYRIDINE-3-CARBOXYLA&;Methyl 2,6-dichloropyridin-3-carboxylate;Methyl 2,6-Dichloro-3-pyridinecarboxylate;2,6-Dichloropyridine-3-carboxylic acid methyl ester
- CBNumber:
- CB3500167
- Molecular Formula:
- C7H5Cl2NO2
- Molecular Weight:
- 206.03
- MDL Number:
- MFCD07369794
- MOL File:
- 65515-28-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 56-60 °C(lit.) |
|---|---|
| Boiling point | 270.5±35.0 °C(Predicted) |
| Density | 1.426±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | -4.55±0.10(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| Sensitive | Air Sensitive |
| λmax | 276nm(lit.) |
| InChI | InChI=1S/C7H5Cl2NO2/c1-12-7(11)4-2-3-5(8)10-6(4)9/h2-3H,1H3 |
| InChIKey | IFVVGOJYWCHRCT-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=CC=C1C(OC)=O |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Methyl 2,6-dichloronicotinate price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 656437 | Methyl 2,6-dichloropyridine-3-carboxylate 97% | 65515-28-8 | 1g | $95.1 | 2023-01-07 | Buy |
| TCI Chemical | M2616 | Methyl 2,6-Dichloronicotinate >98.0%(GC) | 65515-28-8 | 1g | $28 | 2026-04-30 | Buy |
| TCI Chemical | M2616 | Methyl 2,6-Dichloronicotinate >98.0%(GC) | 65515-28-8 | 5g | $98 | 2026-04-30 | Buy |
| Biosynth | QCA51528 | Methyl 2,6-dichloropyridine-3-carboxylate | 65515-28-8 | 100g | $250 | 2026-06-04 | Buy |
| Apolloscientific | OR110405 | Methyl 2,6-dichloronicotinate 98% | 65515-28-8 | 1g | $21 | 2026-06-04 | Buy |
Methyl 2,6-dichloronicotinate Chemical Properties, Uses, Production
Uses
Replacement of chlorides with fluorides using anhydrous nucleophilic fluoride salts generated from potassium fluoride and an arene transfer agent.
Synthesis
67-56-1
38496-18-3
65515-28-8
General procedure for the synthesis of methyl 2,6-dichloronicotinate from methanol and 2,6-dichloronicotinic acid: to a solution of 2,6-dichloronicotinic acid (5.0 g, 26 mmol) in methanol (100 mL) was slowly added thionyl chloride (0.1 mL). The reaction mixture was heated to reflux and kept reacting overnight. Upon completion of the reaction, the solvent was removed by rotary evaporator. The residue was dissolved in ethyl acetate and washed sequentially with saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give methyl 2,6-dichloronicotinate (5.37 g, 100% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ 8.13 (d, J=8.1 Hz, 1H), 7.33 (d, J=8.1 Hz, 1H), 3.94 (s, 3H).
References
[1] Patent: US2005/119251, 2005, A1. Location in patent: Page/Page column 20; 22
[2] Patent: WO2006/14168, 2006, A1. Location in patent: Page/Page column 47
[3] Patent: WO2008/16643, 2008, A2. Location in patent: Page/Page column 233
[4] Patent: WO2006/88836, 2006, A2. Location in patent: Page/Page column 78
[5] Patent: WO2006/88920, 2006, A1. Location in patent: Page/Page column 133-134
Methyl 2,6-dichloronicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangyin Lesen Biotechnology Co., Ltd. | 18961626312 | 125393839@qq.com | China | 228 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 18918157536; | sales8178@energy-chemical.com | China | 45000 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Accela ChemBio Co.,Ltd. | 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
View Latest Price from Methyl 2,6-dichloronicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | METHYL 2 6-DICHLOROPYRIDINE-3-CARBOXYLA
65515-28-8
|
$1.00 | 1kg | 99% | Career Henan Chemical Co |
-
- METHYL 2 6-DICHLOROPYRIDINE-3-CARBOXYLA
65515-28-8
- $1.00
- 99%
- Career Henan Chemical Co
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