ChemicalBook
Chinese Japanese Germany

Dimethyl sulfate

Description References
Dimethyl sulfate
Dimethyl sulfate
CAS No.
77-78-1
Chemical Name:
Dimethyl sulfate
Synonyms
NSC 56194;ai3-52118;Methanesulfate;Dimethylsulfat;Dimetilsolfato;METHYL SULFATE;Methylsulphate;Dimethylsulfaat;DIMETHYL SULFATE;sulfatedemethyle
CBNumber:
CB9854316
Molecular Formula:
C2H6O4S
Formula Weight:
126.13
MOL File:
77-78-1.mol

Dimethyl sulfate Properties

Melting point:
-32 °C
Boiling point:
188 °C(lit.)
Density 
1.333 g/mL at 25 °C(lit.)
vapor density 
4.3 (vs air)
vapor pressure 
0.7 mm Hg ( 25 °C)
refractive index 
n20/D 1.386(lit.)
Flash point:
182 °F
storage temp. 
2-8°C
solubility 
ethanol: 0.26 g/mL, clear, colorless
form 
Liquid
color 
Clear colorless
Odor
Almost odorless
Water Solubility 
2.8 g/100 mL (18 ºC)
Merck 
13,3282
BRN 
635994
Stability:
Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
CAS DataBase Reference
77-78-1(CAS DataBase Reference)
NIST Chemistry Reference
Sulfuric acid, dimethyl ester(77-78-1)
EPA Substance Registry System
Sulfuric acid, dimethyl ester(77-78-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+
Risk Statements  45-25-26-34-43-68
Safety Statements  53-45-61
RIDADR  UN 1595 6.1/PG 1
WGK Germany  2
RTECS  WS8225000
21
Autoignition Temperature 495 °C
HazardClass  6.1(a)
PackingGroup  I
Hazardous Substances Data 77-78-1(Hazardous Substances Data)
Toxicity LD50 orally in rats: 440 mg/kg (Smyth)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Dimethyl sulfate price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 320293 Dimethyl sulfate ≥99% 77-78-1 1l $71.7 2018-11-20 Buy
Sigma-Aldrich 41610 Dimethyl sulfate puriss. p.a., ≥99.0% (GC) 77-78-1 1l $135 2018-11-20 Buy
Sigma-Aldrich D186309 Dimethyl sulfate ≥99.8% 77-78-1 18l-kl $1370 2018-11-20 Buy
Sigma-Aldrich 49497 Dimethyl sulfate for GC derivatization, ≥99.0% (GC) 77-78-1 10ml $78.8 2018-11-20 Buy
Sigma-Aldrich 41610 Dimethyl sulfate puriss. p.a., ≥99.0% (GC) 77-78-1 500ml $79.2 2018-11-20 Buy

Dimethyl sulfate Chemical Properties,Uses,Production

Description

Dimethyl sulfate (chemical formula: (CH3O)2SO2) is an odorless, corrosive, oily liquid which can release toxic fumes during heating. It can be synthesized through the esterification of sulfuric acid with methanol, and alternatively by the distillation of methyl hydrogen sulfate. In industry, dimethyl sulfate is used as a methylating agent for the manufacture of many organic chemicals. It can be used for methylation of phenols, amines, and thiol. Moreover, it can be used for base sequencing and DNA chain cleavage since it can rupture the imidazole rings present in guanine. It can also be used for protein-DNA interaction analysis. However, its vapor is toxic to eyes and lungs, can do harm to our body. It is a potential carcinogen based on known experimental data.

References

https://en.wikipedia.org/wiki/Dimethyl_sulfate
https://pubchem.ncbi.nlm.nih.gov/compound/dimethyl_sulfate#section=Top

Chemical Properties

colourless liquid

Uses

Dimethyl Sulfate is a diester of methanol and sulfuric acid. Dimethyl Sulfate is commonly used as a reagent for the methylation of phenols, amines, and thiols. Dimethyl Sulfate is an effective and widely used probe for sequence-specific protein-DNA interactions

Definition

ChEBI: The dimethyl ester of sulfuric acid.

Uses

Methylating agent in the manufacture of many organic chemicals. War gas.

General Description

Dimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. Dimethyl sulfate is very toxic by inhalation. Dimethyl sulfate is a combustible liquid and has a flash point of 182°F. Dimethyl sulfate is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. Dimethyl sulfate is corrosive to metals and tissue.

Air & Water Reactions

Water soluble.

Reactivity Profile

Pure Dimethyl sulfate and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as Dimethyl sulfate, [MCA Case History No. 1786].

Health Hazard

Acute: extremely toxic vapors and liquid -- a few whiffs or contact on skin could be fatal. Also acutely toxic if ingested. Delayed effects which are ultimately fatal may also occur. Lethal concentrations as low as 97 ppm/10 min have been reported in humans. DNA inhibition and damage to human somatic cells, and sister chromatid exchange in human fibroblast cells were observed. Delayed appearance of symptoms may permit unnoticed exposure to lethal quantities.

Health Hazard

Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. Ingestion of dimethyl sulfate causes burns to the mouth, throat, and gastrointestinal tract. The effects of overexposure to dimethyl sulfate vapor may be delayed. After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Fatal pulmonary edema may develop. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. It is a strong alkylating agent and does produce genetic damage in animals and in bacterial and mammalian cell cultures.

Fire Hazard

Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.

Fire Hazard

Material is normally stable even under fire exposure conditions and is not hazardously reactive with water. Dimethyl sulfate is incompatible with strong oxidizers and strong ammonia solutions.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human poison by inhalation. Experimental poison by ingestion, inhalation, intravenous, and subcutaneous routes. Other experimental reproductive effects. Human mutation datareported. A corrosive irritant to skin, eyes, and mucous membranes. There is no odor or initial irritation to give warning of exposure. On brief, dd exposures, conjunctivitis, catarrhal inflammation of the mucous membranes of the nose, throat, larynx, and trachea, and possibly some reddening of the skin develop after the latent period. With longer, heavier exposures, the cornea shows clouding, the irritation changes to the nasopharynx are more marked, and after 6 to 8 hours pulmonary edema may develop. Death may occur in 3 or 4 days. The liver and kidneys are frequently damaged. Spang of the liquid on the skin can cause ulceration and localnecrosis. In patients surviving severe exposure, there may be serious injury of the liver and hdneys, with suppression of urine, jaunlce, albuminuria, and hematuria appearing. Death, resulting from the hdney or liver damage, may be delayed for several weeks. Flammable when exposed to heat, flame, or oxidizers. Can react with oxidizing materials. Violent reaction with NH4OH and NaN3. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of SOx See also SULFATES.

storage

work with dimethyl sulfate should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn at all times to prevent skin and eye contact.

Incompatibilities

Dimethyl sulfate can react violently with ammonium hydroxide, sodium azide, and strong oxidizers.

Flammability and Explosibility

Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.

Waste Disposal

Excess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.

Dimethyl sulfate Preparation Products And Raw materials

Raw materials

Preparation Products


Dimethyl sulfate Suppliers

Global( 187)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 14297 60
Shanghai Song Yuan Chemical Technology Co., Ltd. 18521000990
86-021-33275113 1492698924@qq.com China 6652 50
Nanjing Huang Tai Pharmaceutical Technology Co. Ltd. 18551845925QQ3569572487
025-58803650 3237333966@qq.com China 1857 58
Shanghai Kangman Biological Technology Co., Ltd. 18800375331
021-50908862 kangmansales@163.com China 7642 55
Chengdu HuaNa Chemicals Co., Ltd. 028-86612776 13699069380
- 515238037@qq.com China 4035 55
Shandong Ono Chemical Co., Ltd. 0539-6362799(To 20)
0539-6362799(To 20) 861669111@qq.com China 10082 58
Dalian Idery Biotechnology Co., Ltd. 0411-62696576/0411-66160116/15141125520
0411-66160116 dlidery@yeah.net China 73 58
Nanjing Vital Chemical Co., Ltd. Please Send Email QQ:3500919436
025-87193546 chemweiao@163.com China 9169 60
Henan Wanxiang Chemical Industry Co., Ltd. 0371-56669001;0371-56669008
0371-56669008 sales@wanxiangchem.com China 782 58

Dimethyl sulfate Spectrum


77-78-1(Dimethyl sulfate)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved