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GW583340 DIHYDROCHLORIDE

GW583340 DIHYDROCHLORIDE Structure
GW583340 DIHYDROCHLORIDE structure
CAS No.
388082-81-3
Chemical Name:
GW583340 DIHYDROCHLORIDE
Synonyms
4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]P;4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-;4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride
CBNumber:
CB3503522
Molecular Formula:
C28H25ClFN5O3S2
Molecular Weight:
598.11
MDL Number:
MFCD07370137
MOL File:
388082-81-3.mol
Last updated:2023-05-04 17:34:38
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GW583340 DIHYDROCHLORIDE Properties

Melting point 259.8-262.4 °C(lit.)
storage temp. 2-8°C
solubility DMSO: 9 mg/mL
form solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

GW583340 DIHYDROCHLORIDE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation KIN0000121 GW-583340 DIHYDROCHLORIDE 95.00% 388082-81-3 10MG $733.72 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000121 GW-583340 DIHYDROCHLORIDE 95.00% 388082-81-3 50MG $1381.33 2021-12-16 Buy
Product number Packaging Price Buy
KIN0000121 10MG $733.72 Buy
KIN0000121 50MG $1381.33 Buy

GW583340 DIHYDROCHLORIDE Chemical Properties,Uses,Production

Definition

ChEBI: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-4-thiazolyl]-4-quinazolinamine is a member of quinazolines.

Biological Activity

Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC 50 values are 0.01 and 0.014 μ M respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2: IC 50 values are 0.11 μ M for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μ M for inhibition of non-tumor cell line HFF. In vivo, inhibits tumor growth by ~ 80% in a murine xenograft model following oral administration.

GW583340 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

GW583340 DIHYDROCHLORIDE Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
EMMX Biotechnology LLC 60

388082-81-3(GW583340 DIHYDROCHLORIDE)Related Search:

3-Chloro-4-(3-fluorobenzyloxy)aniline 4-BENZYLOXY-3-CHLOROANILINE 96 GW583340 DIHYDROCHLORIDE (2-Thiazolyl)methylamine
4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]P 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]- 388082-81-3 C28H25ClFN5O3S22HCl C28H25ClFN5O3S2