ChemicalBook >> CAS DataBase List >>GW583340 DIHYDROCHLORIDE

GW583340 DIHYDROCHLORIDE

GW583340 DIHYDROCHLORIDE structure

CAS No.: 388082-81-3

Chemical Name:: GW583340 DIHYDROCHLORIDE

Synonyms: 4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]P;4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-;4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride

CBNumber:: CB3503522

Molecular Formula:: C28H25ClFN5O3S2

Molecular Weight:: 598.11

MDL Number:: MFCD07370137

MOL File:: 388082-81-3.mol

Last updated:2025-10-29 15:43:00

Product description	Number	Pack Size	Price
GW-583340 DIHYDROCHLORIDE 95.00%	KIN0000121	10MG	$733.72
GW-583340 DIHYDROCHLORIDE 95.00%	KIN0000121	50MG	$1381.33

Request For Quotation

GW583340 DIHYDROCHLORIDE Properties

Melting point	259.8-262.4 °C(lit.)
storage temp.	2-8°C
solubility	DMSO: 9 mg/mL
form	solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

GW583340 DIHYDROCHLORIDE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	KIN0000121	GW-583340 DIHYDROCHLORIDE 95.00%	388082-81-3	10MG	$733.72	2021-12-16	Buy
American Custom Chemicals Corporation	KIN0000121	GW-583340 DIHYDROCHLORIDE 95.00%	388082-81-3	50MG	$1381.33	2021-12-16	Buy

Product number	Packaging	Price	Buy
KIN0000121	10MG	$733.72	Buy
KIN0000121	50MG	$1381.33	Buy

GW583340 DIHYDROCHLORIDE Chemical Properties,Uses,Production

Definition

ChEBI: N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[(2-methylsulfonylethylamino)methyl]-4-thiazolyl]-4-quinazolinamine is a member of quinazolines.

Biological Activity

Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC 50 values are 0.01 and 0.014 μ M respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2: IC 50 values are 0.11 μ M for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μ M for inhibition of non-tumor cell line HFF. In vivo, inhibits tumor growth by ~ 80% in a murine xenograft model following oral administration.

GW583340 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

GW583340 DIHYDROCHLORIDE Suppliers

Global( 9)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15838	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Santa Cruz Biotechnology Inc	021-60936350	scbt@scbt.com	China	6594	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
EMMX Biotechnology LLC	60
Santa Cruz Biotechnology Inc	58

GW583340 DIHYDROCHLORIDE Spectrum

GW583340 DIHYDROCHLORIDE(388082-81-3)¹HNMR

388082-81-3(GW583340 DIHYDROCHLORIDE)Related Search:

3-Chloro-4-(3-fluorobenzyloxy)aniline 4-BENZYLOXY-3-CHLOROANILINE 96 GW583340 DIHYDROCHLORIDE (2-Thiazolyl)methylamine

4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]P 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]- 388082-81-3 C28H25ClFN5O3S22HCl C28H25ClFN5O3S2