P1075
- CAS No.
- 60559-98-0
- Chemical Name:
- P1075
- Synonyms
- P1075;-3-pyridinyl-guanidine;-(1,1-dimethylpropyl)-N’2-cyano-1-tert-pentyl-3-(3-pyridyl)guanidine;2-cyano-1-tert-pentyl-3-(3-pyridyl)-guanidin;N-CYANO-N'-(1,1-DIMETHYLPROPYL)-N''-3-PYRIDYLGUANIDINE;n-cyano-n’-(1,1-dimethylpropyl)-n’’-3-pyridinyl-guanidin;N-cyano-N'-(1,1-dimethylpropyl)-N''-(3-pyridinyl)guanidine;Guanidine, N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridinyl-;Inhibitor,Potassium Channel,P1075,KcsA,COS-7,adult rabbit cardiomyocytes,inhibit,P 1075,P-1075
- CBNumber:
- CB3682098
- Molecular Formula:
- C12H17N5
- Molecular Weight:
- 231.3
- MDL Number:
- MFCD00914293
- MOL File:
- 60559-98-0.mol
- MSDS File:
- SDS
| Melting point | 186-187 °C |
|---|---|
| Boiling point | 347.6±34.0 °C(Predicted) |
| Density | 1.07±0.1 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
| form | Powder |
| pka | 4.74±0.11(Predicted) |
| FDA UNII | RA77IZ6B2F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| NFPA 704 |
|
P1075 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21849 | P1075 ≥98% | 60559-98-0 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 21849 | P1075 ≥98% | 60559-98-0 | 5mg | $179 | 2024-03-01 | Buy |
| Tocris | 1355 | P1075 ≥99%(HPLC) | 60559-98-0 | 10 | $210 | 2021-12-16 | Buy |
| Tocris | 1355 | P1075 ≥99%(HPLC) | 60559-98-0 | 50 | $882 | 2021-12-16 | Buy |
| Usbiological | 256142 | P1075 | 60559-98-0 | 10mg | $466 | 2021-12-16 | Buy |
P1075 Chemical Properties,Uses,Production
Uses
N-Cyano-N''-(1,1-dimethylpropyl)-N''''-3-pyridinyl-guanidine is an ATP-sensitive potassium channels activator or opener (KATPCO) by causing relaxation of various isolated animal and human blood vessels.
Definition
ChEBI: 1-cyano-2-(2-methylbutan-2-yl)-3-(3-pyridinyl)guanidine is a member of pyridines.
Biological Activity
Potent K ATP channel opener (EC 50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (K d values are 17 and 3 nM respectively).
Enzyme inhibitor
This potent potassium ion channel opener, or KCO (FW = 231.30 g/mol; CAS 60559-98-0; Solubility: 50 mM in Ethanol; 100 mM in DMSO), also known as N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridyl-guanidine, targets Kir6 (or KATP) channels (EC50 = 7.5 nM; for relaxation of rat aorta). In studies on rats, rabbit and dogs, P1075 effects only correlate with the presence of specific receptor binding sites in rat vascular preparations, showing there are significant species-specific and raising questions about the pharmacological significance of this KATP opener binding site. These channels are heteromultimers composed with a 4:4 stoichiometry of an inwardly rectifying K+ channel subunit plus a regulatory subunit comprising the receptor sites for hypoglycemic sulfonylureas and KCOs (a sulfonylurea receptor). P1075-induced channel activation IS mediated by drug interaction with a single binding site per tetradimeric complex. P-1075 also binds to sulfonylurea receptors SUR2A (Kd = 17 nM) and SUR2B (Kd = 3 nM)
P1075 Preparation Products And Raw materials
Raw materials
Preparation Products
P1075 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3156 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |