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BENZO[A]PYRENE

Description References
BENZO[A]PYRENE
BENZO[A]PYRENE structure
CAS No.
50-32-8
Chemical Name:
BENZO[A]PYRENE
Synonyms
BP;BAP;HPA1S;3,4-BP;NSC 21914;HP2ALPHA2;Benzpyrene;BENZOPYRENE;BENZ[A]PYRENE;Benzo(a)pyren
CBNumber:
CB3696680
Molecular Formula:
C20H12
Formula Weight:
252.31
MOL File:
50-32-8.mol

BENZO[A]PYRENE Properties

Melting point:
177-180°C
Boiling point:
495°C
Density 
1.1549 (estimate)
refractive index 
1.8530 (estimate)
Flash point:
495°C
storage temp. 
APPROX 4°C
form 
Crystalline
color 
Pale yellow/green/orange
Water Solubility 
Soluble in benzene, toluene, and xylene. Sparingly soluble in alcohol, methanol. Insoluble in water
Merck 
14,1103
BRN 
1911333
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
FMMWHPNWAFZXNH-UHFFFAOYSA-N
CAS DataBase Reference
50-32-8(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,N,F
Risk Statements  45-46-50/53-60-61-43-67-66-36-11-65-38-52/53-36/37/38
Safety Statements  45-53-61-60-26-62-16
RIDADR  2811
WGK Germany  3
RTECS  DJ3675000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29029090
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H304 May be fatal if swallowed and enters airways Aspiration hazard Category 1 Danger
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

BENZO[A]PYRENE price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 31306 Benzo[a]pyrene solution 100 μg/mL in cyclohexane, analytical standard 50-32-8 2ml $52 2018-11-13 Buy
Sigma-Aldrich 31306 Benzo[a]pyrene solution 100 μg/mL in cyclohexane, analytical standard 50-32-8 10ml $102 2018-11-13 Buy
TCI Chemical B0085 3,4-Benzopyrene (purified by sublimation) >95.0%(GC) 50-32-8 1g $257 2018-11-22 Buy
TCI Chemical B0085 3,4-Benzopyrene (purified by sublimation) >95.0%(GC) 50-32-8 100mg $40 2018-11-22 Buy
Alfa Aesar 015856 Benzo[a]pyrene, 96% 50-32-8 100mg $43.5 2018-11-16 Buy

BENZO[A]PYRENE Chemical Properties,Uses,Production

Description

Benzo[a]pyrene belongs to the class of polycyclic aromatic hydrocarbons (PAHs). It is produced during incomplete combustion or pyrolysis of organic material and found in nature from the eruption of volcanoes and forest fires. Man-made benzo[a]pyrene is formed by burning plants, wood, coal, and operating cars, trucks and other vehicles. It is also present in some foods (e.g. smoked and barbecued meals), in a few pharmaceutical products, and in tobacco smoke. It is considered as potent mutagen and carcinogen. Benzo[a]pyrene containing extender oil is used for the rubber/plastic production to achieve the desired elasticity at a cheaper price. Benzo[a]pyrene containing coal tar pitch is used in many paints or coatings as corrosion protection coats, such as hydraulic equipment, pipework, steel pilings in ports, vessels, and sealcoat products. Benzo[a]pyrene can be used as wood-preservatives to prevent wood parasites and the wood from drying out.

References

  1. https://monographs.iarc.fr/ENG/Monographs/vol100F/mono100F-14.pdf
  2. http://www.dhss.delaware.gov/dph/files/benzopyrenefaq.pdf
  3. https://greenliving.epa.gov.tw
  4. https://www.umweltbundesamt.de
  5. Barbara J. Mahler, Peter C. Van Metre, Judy L. Crane, Alison W. Watts,  Mateo Scoggins, and E. Spencer Williams, Coal-Tar-Based Pavement Sealcoat and PAHs: Implications for the Environment, Human Health, and Stormwater Management, Environ Sci Technol, 2012, vol. 46, 3039-3045

Chemical Properties

yellow crystals or powder [found in cigarette smoke,

Chemical Properties

B(a)P, is yellowish needles, crystals or powder. Odorless. PAHs are compounds containing multiple benzene rings and are also called polynuclear aromatic hydrocarbons.

Uses

Benzopyrene is a polyaromatic hydrocarbon (PAH) found in coal tar. Benzopyrene is a known carcinogen. The metbolism of Benzopyrene results in diol epoxides that react and bind to DNA forming adducts which in turns leads to mutations and eventually cancer.

Definition

ChEBI: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.

Definition

A cyclic aromatic hydrocarbon with a structure consisting of five fused benzene rings. It occurs in coal tar and tobacco smoke and has strong carcinogenic properties.

Definition

benzopyrene: A crystalline aromatichydrocarbon, C20H12; m.p.179°C. It is found in coal tar and ishighly carcinogenic.

Definition

benzpyrene: A pale yellow solid,C20H12, m.p. 179°C, whose moleculesconsist of five fused benzene rings. Itoccurs in tars from coal and tobaccosmoke and is a carcinogen.

General Description

A liquid. Presents a threat to the environment. Immediate steps should be taken to limits its spread to the environment. Easily penetrates the soil and contaminates groundwater or nearby waterways.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

BENZO[A]PYRENE undergoes photo-oxidation after irradiation in indoor sunlight or by fluorescent light in organic solvents. Incompatible with strong oxidizing agents including various electrophiles, peroxides, nitrogen oxides and sulfur oxides. Oxidized by ozone, chromic acid and chlorinating agents. Readily undergoes nitration and halogenation. Hydrogenation occurs with platinum oxide .

Hazard

Highly toxic, confirmed carcinogen by inhalation.

Health Hazard

The acute oral toxicity of benzo[a]pyrene islow. This may be due to the poor absorption of this compound by the gastrointestinal tract.The lethal dose in mice from intraperitonealadministration is reported as 500 mg/kg(NIOSH 1986).
Animal studies show sufficient evidence ofits carcinogenicity by all routes of exposureaffecting a variety of tissues, which includethe lungs, skin, liver, kidney, and blood.
Dasenbrock et al. (1996) have investigatedthe carcinogenic potency of carbon particles,diesel soot and benzo[a]pyrene in rats fromrepeated intracheal administration in a 16-week study. A total dose of 15 mg purebenzo[a]pyrene caused lung tumor in theexperimental animals at a rate similar tothat caused by diesel soot and carbon blackparticles.
Lodovici et al. (1998) measured the levelsof PAHs and benzo[a]pyrenediol epoxideDNA adduct in autoptic lung samples ofsmokers and non-smokers. Benzo[a]pyrenediol epoxide resulting from metabolic activation of benzo[a]pyrene binds to DNA to forman adduct, the levels of which can be used as abiomarker to evaluate the exposure of humansto benzo(a)pyrene.
Benz[a]pyrene exhibited teratogeniceffects in test species. It is a mutagen.It showed positive in a histidine rever-sion–Ames test, cell transform mouse embryotest, and in in vitro sister chromatid exchange(SCE)–human lymphocytes..

Fire Hazard

Literature sources indicate that BENZO[A]PYRENE is nonflammable.

Toxicology

benzo[a]pyrene (BP) is a reasonably potent contact carcinogen, and therefore has been subjected to extensive carcinogenic testing. A diet containing 25 ppm of benzo[a]pyrene (BP) fed to mice for 140 days produced leukemia and lung adenomas in addition to stomach tumors. Skin tumors developed in over 60% of the rats treated topically with approximately 10 mg of benzo[a]pyrene three times per week. The incidence of skin tumors dropped to about 20% when treatment was about 3 mg  3 per week. Above the 10 mg range, however, the incidence of skin tumors increased dramatically to nearly 100%. benzo[a]pyrene (BP) is also carcinogenic when administered orally. In one experiment, weekly doses of greater than 10 mg administered for 10 weeks induced stomach cancers, although no stomach cancers were produced at the dose of 10 mg or less. At 100 mg doses, nearly 79% of the animals had developed stomach tumors by the completion of the experiment. When 15 ppm of benzo[a]pyrene (BP) in feed was orally administered to mice, production of leukemia, lung adenomas, and stomach tumors were observed after 140 days.

Potential Exposure

Benzopyrene (BP) is a PAH that has no commercial-scale production. B(a)P is produced in the United States by one chemical company and distributed by several specialty chemical companies in quantities from 100 mg to 5 g for research purposes. Although not manufactured in great quantity, B(a)P is a by-product of combustion. It is estimated that 1.8 million pounds per year are released from stationary sources, with 96% coming from: (1) coal refuse piles, outcrops, and abandoned coal mines; (2) residential external combustion of bituminous coal; (3) coke manufacture; and (4) residential external combustion of anthracite coal. Human exposure to B(a)P can occur from its presence as a by-product of chemical production. The number of persons exposed is not known. Persons working at airports in tarring operations; refuse incinerator operations; power plants, and coke manufacturers, may be exposed to higher B(a)P levels than the general population. Scientists involved in cancer research or in sampling toxic materials may also be occupationally exposed. The general population may be exposed to B(a)P from air pollution, cigarette smoke, and food sources. B(a) P has been detected in cigarette smoke at levels ranging from 0.2 to 12.2:g per 100 cigarettes. B(a)P has been detected at low levels in foods ranging from 0.1 to 50 ppb.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

Purification Methods

A solution of 250mg of benzo[a]pyrene in 100mL of *benzene is diluted with an equal volume of hexane, then passed through a column of alumina, Ca(OH)2 and Celite (3:1:1). The adsorbed material is developed with a 2:3 *benzene/hexane mixture. (It showed as an intensely fluorescent zone.) The main zone is eluted with 3:1 acetone/EtOH, and is transferred into 1:1 *benzene-hexane by adding H2O. The solution is washed, dried with Na2SO4, evaporated and crystallised from *benzene by the addition of MeOH [Lijinsky & Zechmeister J Am Chem Soc 75 5495 1953]. Alternatively it can be chromatographed on activated alumina, eluted with a cyclohexane-*benzene mixture containing up to 8% *benzene, and the solvent evaporated under reduced pressure [Cahnmann Anal Chem 27 1235 1955], and crystallised from EtOH [Nithipatikom & McGown Anal Chem 58 3145 1986]. [Beilstein 5 III 2517, 5 IV 2687.] CARCINOGENIC.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, nitrogen dioxide and ozone.

Waste Disposal

Incineration in admixture with a flammable solvent.

BENZO[A]PYRENE Preparation Products And Raw materials

Raw materials

Preparation Products


BENZO[A]PYRENE Suppliers

Global( 146)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22043 58
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0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Adamas Reagent, Ltd. 400-600-9262
bxy@titansci.com China 14014 59
Shandong XiYa Chemical Industry Co., Ltd 4008-626-111
0539-6365991 3229735657@qq.com China 26860 60
Biokitchen 021-31663258 13795219287
021-31663258 stephendong@biokitchen.net China 3440 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40395 62
future industrial shanghai co., ltd 400-0066-400;021-60496031
021-55660885 sales@jonln.com China 2042 65
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30291 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24648 81

BENZO[A]PYRENE Spectrum


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