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TISSUE PLASMINOGEN ACTIVATOR, HUMAN

TISSUE PLASMINOGEN ACTIVATOR, HUMAN structure

CAS No.: 189263-81-8

Chemical Name:: TISSUE PLASMINOGEN ACTIVATOR, HUMAN

Synonyms: TISSUE PLASMINOGEN ACTIVATOR;TPA;TPA, HUMAN;1-CHAIN TPA;2-CHAIN TPA;TISSUE PLASMINOGEN ACTIVATOR, HUMAN;TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN;TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN;9,10-Bis[N-(m-tolyl)anilino]anthracene;9,10-Bis[N-(m-tolyl)anilino]anthracene

CBNumber:: CB3746518

Molecular Formula:: C40H32N2

Molecular Weight:: 540.7

MDL Number:: MFCD00166068

MOL File:: 189263-81-8.mol

MSDS File:: SDS

Last updated:2023-06-08 17:06:34

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TISSUE PLASMINOGEN ACTIVATOR, HUMAN Properties

Melting point	262 °C
Boiling point	723.8±53.0 °C(Predicted)
Density	1.194±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	-0.33±0.50(Predicted)
form	Lyophilized
color	Light yellow to Yellow to Orange
NCI Dictionary of Cancer Terms	tissue plasminogen activator; tPA

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36
WGK Germany	1
HS Code	2921.59.8090

TISSUE PLASMINOGEN ACTIVATOR, HUMAN price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T0831	Tissue plasminogen activator human		100μG	$512	2023-06-20	Buy
Sigma-Aldrich	T0831	Tissue plasminogen activator human	189263-81-8	1MG	$1150	2023-06-20	Buy
Sigma-Aldrich	T0831	Tissue plasminogen activator human	189263-81-8	100UG	$426	2022-05-15	Buy
TCI Chemical	B4965	9,10-Bis[N-(m-tolyl)anilino]anthracene >98.0%(HPLC)	189263-81-8	1g	$268	2024-03-01	Buy
TCI Chemical	B4965	9,10-Bis[N-(m-tolyl)anilino]anthracene >98.0%(HPLC)	189263-81-8	200mg	$78	2024-03-01	Buy

Product number	Packaging	Price	Buy
T0831	100μG	$512	Buy
T0831	1MG	$1150	Buy
T0831	100UG	$426	Buy
B4965	1g	$268	Buy
B4965	200mg	$78	Buy

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Chemical Properties,Uses,Production

Chemical Properties

off-white powder

Uses

Tissue plasminogen activator has been used in a study to assess treatment risks of intracranial hemorrhage among patients with acute ischemic stroke. Tissue plasminogen activator has also been used in a study to investigate the successful treatment of early thrombosis of HeartWare left ventricular assist devices with intraventricular thrombolytics. Human tissue plasminogen activator has been used to study the effect of tyrosinase-related protein 2 (TRP-2) expression on melanin production in sheep.

General Description

Recombinant tPA (rtPA), alteplase (Activase), is identicalwith endogenous tPA. rtPA lacks a glycosyl residue atAsn184. At one time, rtPA was produced in two-chain formin CHO cultures. Now, large-scale cultures of recombinanthuman melanoma cells in fermenters are used to produce aproduct that is about 80% single-chain rtPA.
Alteplase is used to improve ventricular function followingan acute myocardial infarction, including reducing the incidenceof congestive heart failure and decreasing mortality.The drug is also used to treat acute ischemic stroke aftercomputed tomography (CT) or other diagnostic imaging hasruled out intracranial hemorrhage. rtPA is also used in casesof acute pulmonary thromboembolism and is being investigatedfor unstable angina pectoris.
Alteplase is supplied as powder for injection, and in reconstitutedform (normal saline or 5% dextrose in water) isintended for IV infusion only. The solution expires in 8 hoursat room temperature and must be prepared just before use.

Biochem/physiol Actions

tPA is a potent activator of fibrinolysis and converts plasminogen into plasmin and also initiates cell signaling. The plasminogen activation system may also be associated with degradation of amyloid fibrils. It is also known to mediate inflammatory and extracellular matrix remodeling processes and is predicted to participate in disease progression of intracranial aneurysm indicating brain vascular malformations. Upregulation of the gene is observed in aortic aneurysms.

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products

TISSUE PLASMINOGEN ACTIVATOR, HUMAN Suppliers

Global( 70)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
CHG Opto-Electronic Corporation Limited	2537653158 16621191650	2537653158@qq.com	China	7356	58
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24539	81
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 031166536426	master@sjzsdyn.com	China	2882	65
Adamas Reagent, Ltd.	400-6009262 16621234537	zhangsn@titansci.com	China	14113	59

Supplier	Advantage
Career Henan Chemica Co	58
Alfa Chemistry	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
CHG Opto-Electronic Corporation Limited	58
TCI (Shanghai) Development Co., Ltd.	81
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Adamas Reagent, Ltd.	59

189263-81-8(TISSUE PLASMINOGEN ACTIVATOR, HUMAN)Related Search:

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Tissue Plasminogen Activator

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2-CHAIN TPA 1-CHAIN TPA Tissue Plasminogen Activator from human melanoma cells 9,10-Bis[N-(m-tolyl)anilino]anthracene TISSUE PLASMINOGEN ACTIVATOR, HUMANphenyl)-N,N'-diphenyl- TISSUE PLASMINOGEN ACTIVATOR, HUMAN TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN TPA, HUMAN TPA 9,10-Bis[N-(m-tolyl)anilino]anthracene 9-N,10-N-bis(3-methylphenyl)-9-N,10-N-diphenylanthracene-9,10-diamine 9,10-Anthracenediamine, N9,N10-bis(3-methylphenyl)-N9,N10-diphenyl- N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-9,10-anthracenediamine N,N'-Diphenyl-N,N'-di(m-tolyl)-9,10-anthracenediamine N9,N10-Diphenyl-N9,N10-di-m-tolylanthracene-9,10-diamine TISSUE PLASMINOGEN ACTIVATOR 189263-81-8 Serum Related EnzymesEnzymes, Inhibitors, and Substrates Therapeutic EnzymesProteolytic Enzymes and Substrates Tissue Plasminogen Activator Application Index Proteases&Protein Sequencing ProteasesApplication Index Selective Proteolytic Enzymes Serum Proteins and Related Enzymes