Aminoquinol
- CAS No.
- 10023-54-8
- Chemical Name:
- Aminoquinol
- Synonyms
- Aminoquinol;Aminoquinol DISCONTINUED. Please see C609759.;7-Chloro-2-(o-chlorostyryl)-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline;1,4-Pentanediamine, N4-[7-chloro-2-[2-(2-chlorophenyl)ethenyl]-4-quinolinyl]-N1,N1-diethyl-;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-dia;N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quin olin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diami;N4-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediamine tris(phosphate)
- CBNumber:
- CB41178009
- Molecular Formula:
- C26H31Cl2N3
- Molecular Weight:
- 456.45
- MDL Number:
- MFCD01709344
- MOL File:
- 10023-54-8.mol
| Melting point | 223-225° |
|---|---|
| Boiling point | 597.1±50.0 °C(Predicted) |
| Density | 1.191±0.06 g/cm3(Predicted) |
| storage temp. | RT |
| solubility | Soluble in DMSO (up to 25 mg/ml with warming). |
| form | solid |
| pka | 10.47±0.25(Predicted) |
| color | Light brown |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| FDA UNII | CH1Y88E2AY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H413 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| HazardClass | IRRITANT |
Aminoquinol price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 009881 | N-*4*-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N*1*,N*1*-diethyl-pentane-1,4-diamine triphosphate | 10023-54-8 | 1g | $378 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0025379 | AMINOQUINOL 95.00% | 10023-54-8 | 5MG | $501.2 | 2021-12-16 | Buy |
| AK Scientific | 7133AC | N4-{7-Chloro-2-[2-(2-chloro-phenyl)-vinyl]-quinolin-4-yl}-N1,N1-diethyl-pentane-1,4-diamine | 10023-54-8 | 1g | $560 | 2021-12-16 | Buy |
| Aronis compounds | e00599 | N4-{7-chloro-2-[2-(2-chlorophenyl)vinyl]-4-quinolinyl}-N1,N1-diethyl-1,4-pentanediaminetris(phosphate) | 10023-54-8 | 20mg | $30 | 2021-12-16 | Buy |
Aminoquinol Chemical Properties,Uses,Production
Description
XIB4035 (10023-54-8) is a novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50?= 10.4 μM. Like GDNF, XIB4035 induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells.1?Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3? GDNF agonists may be a new class of Parkinson’s disease therapeutics.4
References
1) Tokugawa?et al. (2003),?XIB4035, a novel nonpeptidyl small molecule agonist for GFRα-1; Neurochem. Int.,?42?81 2) Hedstrom?et al. (2014),?Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling; Proc. Natl. Acad. Sci. USA,?111?2325 3) Hsieh?et al.?(2018)?Distinct TrkA and Ret modulated negative and positive neuropathic behaviors in a mouse model of resiniferatoxin-induced small fiber neuropathy; Exp. Neurol.?300?87 4) Drinkut?et al.?(2016)?Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in Parkinson disease mouse model; Cell Death Dis.,?7?e2359
Aminoquinol Preparation Products And Raw materials
Raw materials
Preparation Products
Aminoquinol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Wuhan Topule | +86-02787215551 +86-19945035818 | 2936752263@qq.com | China | 7955 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2881924765@qq.com | China | 7977 | 58 |
| Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. | +86-027-59232304 15387063101 | 2881924050@qq.com | China | 9892 | 58 |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17721492509 | 643638326@qq.com | China | 5347 | 58 |
| Aronis | -- | aronis@aronis.ru | Russia | 6593 | 60 |