Ravuconazole
- CAS No.
- 182760-06-1
- Chemical Name:
- Ravuconazole
- Synonyms
- Rcz;Er-30346;Aids057176;Bms-207147;The health;Bms-207,147;Aids-057176;Ravuconazole;Levaconazole;BMS-207147/Ravuconazole
- CBNumber:
- CB41257944
- Molecular Formula:
- C22H17F2N5OS
- Molecular Weight:
- 437.47
- MDL Number:
- MFCD00941002
- MOL File:
- 182760-06-1.mol
| Melting point | 64-66°C |
|---|---|
| alpha | D24 -29.1° (c = 1.03 in methanol) |
| Boiling point | 674.9±65.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml |
| form | A crystalline solid |
| pka | 11.62±0.29(Predicted) |
| FDA UNII | 95YH599JWV |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P337+P313 | |||||||||
| NFPA 704 |
|
Ravuconazole price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1216 | Ravuconazole ≥97% (NMR) | 182760-06-1 | 5mg | $132 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1216 | Ravuconazole ≥97% (NMR) | 182760-06-1 | 25MG | $520 | 2024-03-01 | Buy |
| Cayman Chemical | 18750 | Ravuconazole ≥98% | 182760-06-1 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18750 | Ravuconazole ≥98% | 182760-06-1 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 18750 | Ravuconazole ≥98% | 182760-06-1 | 10mg | $193 | 2024-03-01 | Buy |
Ravuconazole Chemical Properties,Uses,Production
Description
Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml). Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes. Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51). As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.
Chemical Properties
Off-White Solid
Uses
Ergosterol biosynthesis inhibitor. Antifungal.
Definition
ChEBI: Ravuconazole is a member of the class of triazoles that is 1-butyl-1H-1,2,4-triazole in which the butyl group is substituted at positions 2, 2, and 3 by hydroxy, 2,4-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively (the R,R stereoisomer). It exhibits antifungal activity by inhibition of 14alpha demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCIO4) It has a role as an ergosterol biosynthesis inhibitor, an antifungal drug, an EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitor and an antileishmanial agent. It is a member of triazoles, a member of fluorobenzenes, a tertiary alcohol, a member of 1,3-thiazoles and a nitrile.
Ravuconazole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Qiuxian Baitai New Material Co., LTD | +8618330912755 | sale2@hbyalin.com | China | 1677 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | mack@tongyon.com | China | 2996 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15745 | 58 |
View Lastest Price from Ravuconazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile pictures](/ProductImageEN/2021-11/Small/eb9a5145-270a-4ef0-9992-9a81f7337f03.jpg) |
2021-11-27 | 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile
182760-06-1
|
US $110.00 / KG | 100g | 99.99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | |
![4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/3091d08c-401f-44fe-bf9c-7784d0ed97bc.jpg) |
2019-12-26 | 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile
182760-06-1
|
US $1.00 / g | 1g | ≥98% | g/kg/Ton | Career Henan Chemical Co |
-
- 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile
182760-06-1
- US $110.00 / KG
- 99.99%
- Qiuxian Baitai New Material Co., LTD
-
- 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile
182760-06-1
- US $1.00 / g
- ≥98%
- Career Henan Chemical Co