AC-YVAD-CHO
- CAS No.
- 143313-51-3
- Chemical Name:
- AC-YVAD-CHO
- Synonyms
- YVAD-CHO;L-709049;AC-YVAD-CHO;ICE INHIBITOR;ICE INHIBITOR I;AC-YVAD-ALDEHYDE;TYR-VAL-ALA-ASP-CHO;CASPASE INHIBITOR I;BIOTINYL-AC-YVAD-CHO;ACETYL-YVAD-ALDEHYDE
- CBNumber:
- CB4158149
- Molecular Formula:
- C23H32N4O8
- Molecular Weight:
- 492.52
- MDL Number:
- MFCD00237123
- MOL File:
- 143313-51-3.mol
- MSDS File:
- SDS
Boiling point | 937.7±65.0 °C(Predicted) |
---|---|
Density | 1.276±0.06 g/cm3(Predicted) |
storage temp. | −20°C |
solubility |
DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM) |
form | Powder |
pka | 4.20±0.10(Predicted) |
Sensitive | Moisture Sensitive |
FDA UNII | NVF6UYC3CM |
AC-YVAD-CHO price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 400010 | Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. | 143313-51-3 | 1MG | $99.4 | 2024-03-01 | Buy |
Sigma-Aldrich | 400010 | Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications. | 143313-51-3 | 5MG | $432 | 2024-03-01 | Buy |
Alfa Aesar | J64407 | Caspase-1 Inhibitor I | 143313-51-3 | 1mg | $87.6 | 2023-06-20 | Buy |
Alfa Aesar | J64407 | Caspase-1 Inhibitor I | 143313-51-3 | 5mg | $308 | 2023-06-20 | Buy |
Cayman Chemical | 10016 | Ac-YVAD-CHO ≥98% | 143313-51-3 | 1mg | $57 | 2024-03-01 | Buy |
AC-YVAD-CHO Chemical Properties,Uses,Production
Description
Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.
Uses
A potent, specific, and reversible inhibitor of caspases-1, -4 and -5
AC-YVAD-CHO Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27333 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
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