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SL 327

SL 327 Structure
SL 327 structure
CAS No.
305350-87-2
Chemical Name:
SL 327
Synonyms
SL 327;CS-1890;SL 327; SL-327;SL 327 USP/EP/BP;MEK Inhibitor VII;Mek-1/Mek-2 Inhibitor;MEK Inhibitor VII SL327 SL-327;SL327;SL-327;MEK-1/MEK-2 INHIBITOR;3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile;α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
CBNumber:
CB4168773
Molecular Formula:
C16H12F3N3S
Molecular Weight:
335.35
MDL Number:
MFCD06411432
MOL File:
305350-87-2.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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SL 327 Properties

Melting point 127-128.2 °C
Boiling point 512.6±50.0 °C(Predicted)
Density 1.40
storage temp. 2-8°C
solubility DMSO: 32 mg/mL
form solid
pka 3.42±0.10(Predicted)
color white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3
HS Code  2930909899

SL 327 price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S4069 SL327 ≥98% (HPLC), Mixture of E & Z isomers, solid 305350-87-2 5mg $173 2024-03-01 Buy
Sigma-Aldrich S4069 SL327 ≥98% (HPLC), Mixture of E & Z isomers, solid 305350-87-2 25mg $251.2 2024-03-01 Buy
Cayman Chemical 15598 SL 327 ≥95% (mixture of cis/trans isomers) 305350-87-2 1mg $57 2024-03-01 Buy
Cayman Chemical 15598 SL 327 ≥95% (mixture of cis/trans isomers) 305350-87-2 5mg $81 2024-03-01 Buy
Cayman Chemical 15598 SL 327 ≥95% (mixture of cis/trans isomers) 305350-87-2 10mg $139 2024-03-01 Buy
Product number Packaging Price Buy
S4069 5mg $173 Buy
S4069 25mg $251.2 Buy
15598 1mg $57 Buy
15598 5mg $81 Buy
15598 10mg $139 Buy

SL 327 Chemical Properties,Uses,Production

Description

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC50s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.

Uses

SL-327 is a selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations.

Definition

ChEBI: A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4 aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.

Biological Activity

Selective inhibitor of MEK1 and MEK2 (IC 50 values are 0.18 and 0.22 μ M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Biochem/physiol Actions

SL327 is a selective MEK1/2inhibitor (IC50 values are 0.18 and 0.22 μM for MEK1 and MEK2 respectively), which blocks hippocampal LTP in vitro. SL327 is a brain penetrant in vivo blocking fear conditioning and learning in rats, and producing neuroprotection in mice following systemic administration.

storage

+4°C (desiccate)

SL 327 Preparation Products And Raw materials

Raw materials

Preparation Products

SL 327 Suppliers

Global( 133)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5909 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 27537 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Shandong chuangyingchemical Co., Ltd. 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58

View Lastest Price from SL 327 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile pictures 2019-12-23 (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
305350-87-2
 US $1.00 / KG 1KG Min98% HPLC g/kg/ton Career Henan Chemical Co

SL 327 Spectrum

SL 327(305350-87-2)MS

305350-87-2(SL 327)Related Search:

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PD 0325901 Benzeneacetonitrile 2-(TRIFLUOROMETHYL)PHENYLACETONITRILE SL 327

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ALPHA-[AMINO[(4-AMINOPHENYL)THIO]METHYLENE]-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE ALPHA-[AMINO-(4-AMINOPHENYLTHIO)METHYLENE)-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE SL 327 Z-EPSILON-T E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE Z-AND E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE a-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile (2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile MEK Inhibitor VII (Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile SL 327 SL 327 alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile Mek-1/Mek-2 Inhibitor SL327;SL-327;MEK-1/MEK-2 INHIBITOR (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile SL 327; SL-327 CS-1890 Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- 3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile SL 327 USP/EP/BP MEK Inhibitor VII SL327 SL-327 Mitogen-activated protein kinase kinase,SL327,MEK,inhibit,Inhibitor,MAPKK,MAP2K Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)- 305350-87-2 C16H12F3O3S Kinase/Phosphatase Biology Mitogen-Activated Protein Kinase Kinase (MAPKK) Serine/Threonine Kinase Inhibitors Cell Signaling and Neuroscience BioChemical Cell Biology Inhibitors Protein Kinase Signalling MAPK