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Selumetinib

Indications and Usage Mechanisms of Action Clinical Research
Selumetinib
Selumetinib structure
CAS No.
606143-52-6
Chemical Name:
Selumetinib
Synonyms
AZD 6244;AZD-6224;ARRY 142886;Esaxerenone;Selumetinib;Array142886;Selumetinib AZD624;Selumetinib, >=98%;AZD6244(SeluMetinib);SeluMetinib (AZD6244)
CBNumber:
CB81871940
Molecular Formula:
C17H15BrClFN4O3
Formula Weight:
457.685
MOL File:
606143-52-6.mol

Selumetinib Properties

Density 
1.69

SAFETY

Selumetinib price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 11599 AZD 6244 ≥98% 606143-52-6 10mg $49 2018-11-13 Buy
Cayman Chemical 11599 AZD 6244 ≥98% 606143-52-6 25mg $61 2018-11-13 Buy
Cayman Chemical 11599 AZD 6244 ≥98% 606143-52-6 50mg $86 2018-11-13 Buy
Cayman Chemical 11599 AZD 6244 ≥98% 606143-52-6 100mg $123 2018-11-13 Buy

Selumetinib Chemical Properties,Uses,Production

Indications and Usage

Selumetinib, 1 has a chemical name of 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide. It was developed by British company AstraZeneca and is used to treat advanced non-small cell lung cancer (NSCLC). It is mainly used to treat bile duct cancer, colon cancer, NSCLC, etc. Currently, Selumetinib is in stage III clinical trials for treatment of NSCLC.

Mechanisms of Action

Selumetinib is the first mitogenextracellular kinase (MEK1/2) inhibitor to be used in thyroid cancer clinical trials. It inhibits extracellular signal regulating kinase (ERK/2) and activates caspase to dramatically inhibit ERK1/2 phosphorylation.

Clinical Research

In phase II clinical trials of radioiodine-refractory papillary thyroid carcinoma, 39 patients took daily oral doses of Selumetinib (100mg bid) for 28 days; results showed that 21 patients’ conditions stabilized (54%), 11 patients’ conditions worsened (28%), 49% patients’ conditions were stable for 16 weeks, 36% patients’ conditions were stable for 24 weeks, and survival terms did not progress to 32 weeks. Negative reactions mainly consisted of rashes (59%), diarrhea (44%), and weakness (41%). Some studies found that after treating 20 patients with thyroid cancer with Selumetinib (75mg bid) for 4 weeks, Selumetinib increased the iodine uptake and retention of patients with radioiodine-refractory papillary thyroid carcinoma. In a blind and random comparative study between a Selumetinib and Docetaxel (DOC) combination treatment group and DOC and placebo treatment group for 87 mutant NSCLSC patients, survival times were 9.4 months and 5.2 months, PFS were 5.3 months and 2.1 months, RR were 37% and 0%, thus showing dramatic differences. Selumetinib’s main negative reactions include neutrophil depletion, dermatitis, and respiratory failure.

Uses

It is a tight-binding, uncompetitive inhibitor of mitogen-activated protein kinase kinases (MEK) 1 and 2 currently in clinical development.

Definition

ChEBI: A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-chlorophenyl)amino, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectiv ly. It is a MEK1 and MEK2 inhibitor.

Selumetinib Preparation Products And Raw materials

Raw materials

Preparation Products


Selumetinib Suppliers

Global( 183)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 303 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20331 58
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 19982 64
Wuhan Chemprospect Pharmaceutical Co., Ltd. 027-84984898 13971349987
027-84984898 sale@chemprospect.com CHINA 27 58
Wuhan NewBaiChuan Pharmaceutical Co., Ltd. 027-50476178;18607136887
QQ644526144 644526144@qq.com China 419 58
Hubei purple cherry chemical co., LTD 15827267957;18162349983
027-88237510 158622387@qq.com China 64 58

View Lastest Price from Selumetinib manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 Selumetinib
606143-52-6
US $2.00 / kg 1kg 99% 100kg career henan chemical co

606143-52-6(Selumetinib)Related Search:


  • AZD6244 (Selumetinib,ARRY-142886)
  • ARRY 142886
  • AZD 6244
  • 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
  • 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
  • Selumetinib AZD624
  • Esaxerenone
  • 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-car
  • Selumetinib, 99%, a highly selective MEK1 inhibitor
  • Selumetinib, Free BaseAZD6244ARRY-142886
  • Selumetinib (AZD6244) Selumetinib
  • Selumetinib
  • 606143-52-6
  • 5-(4-Bromo-2-chlorophenylamino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide
  • 6-(4-Bromo-2-chlorophenylamino)-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-3H-benzo[d]imidazole-5-carboxamide
  • SeluMatinib(5-[(4-BroMo-2-chlorophenyl)aMino]-4-fluoro-N-(2-hydroxyethoxy)-1-Methyl-1H-benziMidazole-6-carboxaMide
  • AZD6244(SeluMetinib)
  • SeluMetinib (AZD6244)
  • Array142886
  • AZD-6244(SeluMetinib)/AZD6244
  • 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carbox
  • AZD6244, ARRY-142886, ARRY-886
  • 5-(4-BroMo-2-chlorophenylaMino)-4-fluoro-1-Methyl-1H-benziMidazole-6-carbohydroxaMic acid 2-hydroxyethyl ester
  • 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide Selumetinib (AZD6244)
  • AZD 6244 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
  • selumetinib (MEK inhibitor)
  • Selumetinib, >=98%
  • AZD-6224
  • -
  • MAPK
  • API
  • Aromatics
  • Heterocycles
  • Inhibitor
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • apis
  • Antineoplastic
  • Inhibitors
  • 60614-52-6
  • C17H15BrClFN4O3
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