Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Pemetrexed

Pemetrexed

Pemetrexed Structure
Pemetrexed structure
CAS No.
137281-23-3
Chemical Name:
Pemetrexed
Synonyms
PEMETREXED;(S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid;Premetred;PEMETREXED;Pemetrexedum;Pemetrexed99%;Pemetrexedaci;(R)-Pemetrexed;PeMetrexed-15C5;PeMetrexed-13C5
CBNumber:
CB4170583
Molecular Formula:
C20H21N5O6
Molecular Weight:
427.41
MDL Number:
MFCD00902635
MOL File:
137281-23-3.mol
Last updated:2024-01-22 14:59:33
Request For Quotation

Pemetrexed Properties

Density 1.59±0.1 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility slightly sol. in Methanol
form powder to crystal
pka 3.58±0.10(Predicted)
color White to Blue
Merck 14,7077
CAS DataBase Reference 137281-23-3(CAS DataBase Reference)
FDA UNII 04Q9AIZ7NO
ATC code L01BA04

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
RTECS  LZ9950100
HS Code  2933.99.9701

Pemetrexed price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical P2288 Pemetrexed Hydrate >98.0%(HPLC)(T) 137281-23-3 250mg $80 2024-03-01 Buy
TCI Chemical P2288 Pemetrexed Hydrate >98.0%(HPLC)(T) 137281-23-3 1g $200 2024-03-01 Buy
Tocris 6185 Pemetrexed ≥98%(HPLC) 137281-23-3 50 $63 2021-12-16 Buy
TRC A604980 N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamicAcid 137281-23-3 250mg $130 2021-12-16 Buy
Biosynth Carbosynth BP164240 Pemetrexed 137281-23-3 100mg $135 2021-12-16 Buy
Product number Packaging Price Buy
P2288 250mg $80 Buy
P2288 1g $200 Buy
6185 50 $63 Buy
A604980 250mg $130 Buy
BP164240 100mg $135 Buy

Pemetrexed Chemical Properties,Uses,Production

Chemical Properties

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt is Off-White Solid

Uses

Pemetrexed is used in the treatment of malignant pleural mesothelioma (MPM) and erectile dysfunction therapy.

Definition

ChEBI: Pemetrexed is an N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antineoplastic agent, an antimetabolite, an EC 2.1.1.45 (thymidylate synthase) inhibitor, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is a pyrrolopyrimidine and a N-acyl-L-glutamic acid. It is a conjugate acid of a pemetrexed(2-).

brand name

Alimta (Lilly).

Side effects

The most common side effects for pemetrexed include fatigue, nausea, vomiting, anorexia, mucositis, myelosuppression ± infection, bleeding, rash, diarrhea and ↑ LFTs.
Severe myelosuppression is often dose-limiting for pemetrexed. Sepsis, in some cases fatal, have occurred in approximately 1% of patients in clinical trials. Prophylactic folic acid and intramuscular vitamin B12 supplements are necessary to reduce hematologic or non-hematologic toxicities.
Pemetrexed may cause serious and in some cases fatal dermatologic toxicities. Rarely, StevensJohnson syndrome and toxic epidermal necrolysis have been reported.

storage

Store at +4°C

Mode of action

Pemetrexed is a pyrrolopyrimidine antifolate that exerts its antineoplastic activity by inhibiting thymidylate synthase (TS), glycinamide ribonucleotide formyltransferase (GARFT) and dihydrofolate reductase (DHFR), which are involved in folate metabolism and DNA synthesis, resulting in inhibition of purine and thymidine nucleotide synthesis.

Pemetrexed synthesis

165049-28-5
137281-23-3
Synthesis of Pemetrexed from N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester 4-methylbenzenesulfonate

Pemetrexed Preparation Products And Raw materials

Raw materials

Preparation Products

Pemetrexed Suppliers

Global( 353)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Million Pharmaceutical Co., Ltd 		+86-531-68659554 +8613031714605 info@millionpharm.com China 153 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
Lianyungang happen teng technology co., LTD 		15950718863 wang666xt@163.com CHINA 295 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 491 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2966 58
Hebei Jimi Trading Co., Ltd. 		+86 319 5273535 bestoneforyou@sina.com CHINA 288 58
Supplier Advantage
Jinan Million Pharmaceutical Co., Ltd 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Lianyungang happen teng technology co., LTD 		58
career henan chemical co 		58
Biochempartner 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58
Jinan Finer Chemical Co., Ltd 		58
Hebei Jimi Trading Co., Ltd. 		58

View Lastest Price from Pemetrexed manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pemetrexed pictures 2024-04-19 Pemetrexed
137281-23-3
 US $1.00-0.50 / kg 1kg 99% 200 Jinan Million Pharmaceutical Co., Ltd
Pemetrexed pictures 2024-04-10 Pemetrexed
137281-23-3
 US $0.00-0.00 / mg 10mg 90%+ 10g Guangzhou PI PI BIOTECH INC
Pemetrexed Disodium pictures 2023-06-26 Pemetrexed Disodium
137281-23-3
 US $200.00 / kg 1kg 99% 1000kg/Month Hebei Mingeng Biotechnology Co., Ltd
  • Pemetrexed pictures
  • Pemetrexed
    137281-23-3
  • US $1.00-0.50 / kg
  • 99%
  • Jinan Million Pharmaceutical Co., Ltd
  • Pemetrexed pictures
  • Pemetrexed
    137281-23-3
  • US $0.00-0.00 / mg
  • 90%+
  • Guangzhou PI PI BIOTECH INC

Pemetrexed Spectrum

Pemetrexed(137281-23-3)1HNMR

137281-23-3(Pemetrexed)Related Search:

Pemetrexed Disodium Pemetrexed disodium hemipentahydrate Pemetrexed Pyrrolo[2,3-d]pyrimidin-4-ol 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine
CHEMBRDG-BB 9071517 2-AMINO-5-METHYL-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE CHEMBRDG-BB 9071952 CHEMBRDG-BB 9071469

1of2

PeMetrexed-13C5 PeMetrexed-15C5 N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-GlutaMic acid (PeMetrexed acid) N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic acid (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedi N-[4-[2-(2-Amino-4,7 (2R)-2-{[4-(2-{2-aMino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid N-(4- 2-(2-AMino-4,7-Dihydro-4-oxo-1H-pyrrol... PeMetrexed disodiuM INT-6 (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid The sour sour of the United States Pemetrexed Hydrate Pemetrexed - Labeled 15N,13C5 (R)-Pemetrexed (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentan PEMETREXED ACID PEMETREXED N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid Pemetrexed99% L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]- N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt PEFLOXACINMESYLATE Premetred disodium Pemetrexedum Premetred PemetrexedHydrate> (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrroL )benzamido)pentanedioic acid 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidi... PemetrexedQ: What is Pemetrexed Q: What is the CAS Number of Pemetrexed Q: What is the storage condition of Pemetrexed Q: What are the applications of Pemetrexed PEMETREXED (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid Pemetrexedaci 137281-23-3 C20H21N5O6xH2O Anti-cancer & immunity API CIALIS