ChemicalBook >> CAS DataBase List >>1,4,7-Triazacyclononane

1,4,7-Triazacyclononane

CAS No.
4730-54-5
Chemical Name:
1,4,7-Triazacyclononane
Synonyms
TACN;157715;1,4,7-triazonane;Triazacyclononane;TRIETHYLENETRIAMINE;1,4,8-Triazacyclononane;1,4,7-Triazacyclonomane;1,4,7-TRIAZACYCLONONANE;Triazacyclononanewhitextl;1,4,7-Triazacyclononane hcl
CBNumber:
CB4234922
Molecular Formula:
C6H15N3
Molecular Weight:
129.2
MDL Number:
MFCD00012358
MOL File:
4730-54-5.mol
MSDS File:
SDS
Last updated:2024-08-12 15:55:19

1,4,7-Triazacyclononane Properties

Melting point 42-45 °C (lit.)
Boiling point 110-130 °C/7 mmHg (lit.)
Density 0.9987 (rough estimate)
refractive index 1.4620 (estimate)
Flash point >230 °F
storage temp. 2-8°C
Water Solubility Soluble in water
solubility Chloroform (Slightly), Methanol (Slightly)
pka 10.57±0.20(Predicted)
form crystal
color white
BRN 773877
InChIKey ITWBWJFEJCHKSN-UHFFFAOYSA-N
FDA UNII 2UIF93C5H3

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 3259 8/PG 2
WGK Germany  3
3-10-34
HazardClass  8
PackingGroup  III
HS Code  2933998090
NFPA 704
1
3 0

1,4,7-Triazacyclononane price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 311308 1,4,7-Triazacyclononane 95% 4730-54-5 100mg $49.6 2024-03-01 Buy
Sigma-Aldrich 311308 1,4,7-Triazacyclononane 95% 4730-54-5 500mg $151.2 2024-03-01 Buy
TCI Chemical T1878 1,4,7-Triazacyclononane >98.0%(GC) 4730-54-5 200mg $60 2024-03-01 Buy
TCI Chemical T1878 1,4,7-Triazacyclononane >98.0%(GC) 4730-54-5 1g $172 2024-03-01 Buy
Strem Chemicals 07-2500 1,4,7-Triazacyclononane, 97% 4730-54-5 25mg $33 2024-03-01 Buy
Product number Packaging Price Buy
311308 100mg $49.6 Buy
311308 500mg $151.2 Buy
T1878 200mg $60 Buy
T1878 1g $172 Buy
07-2500 25mg $33 Buy

1,4,7-Triazacyclononane Chemical Properties,Uses,Production

Description

1,4,7-Triazacyclononane, known as "TACN" which is pronounced "tack-en," is a cyclic organic compound with the formula C6H12(NH)3. TACN is derived, formally speaking, from cyclononane by replacing three equidistant CH2 groups with NH groups. TACN is one of the oligomers derived from aziridine, C2H4NH. Other members of the series include diazacyclohexane, C4H8(NH)2, and the cyclic tetramer 1,4,7,10-tetraazacyclododecane.

Chemical Properties

White - light yellow solid

Uses

Starting material for the synthesis of 1,4,7-trifunctionalized derivatives which have applications in metal complexation.

Uses

1,4,7-Triazacyclononane (TACN) is a versatile platform from which various ligands can be derived to form effective chelators for (radio)copper(II) complexation. The ability of TACN-derivatives to form highly stable complexes with copper(II) is greatly influenced by the number and type of substituents on the macrocyclic ring. The formed copper(II) complexes show a broad variability in their thermodynamic stability and kinetic inertness, varying in structure from square-pyramidal to distorted octahedral. TACN-based BFCAs have also been used for indirect radiolabelling of biomolecules, rendering them suitable for imaging and therapy.

Definition

ChEBI: 1,4,7-triazonane is a saturated organic heteromonocyclic parent, a crown amine and an azacycloalkane.

Preparation

The ligand is prepared from diethylene triamine as follows by macrocyclization using ethyleneglycol ditosylate.
H2NCH2CH2NHCH2CH2NH2 + 3 TsCl → Ts(H)NCH2CH2N(Ts)CH2CHH2N(H)Ts + 3 HCl Ts(H)NCH2CH2N(Ts)CH2CH2N(H)Ts + 2 NaOEt → Ts(Na)NCH2CH2N(Ts)CH2CH2N(Na)Ts Ts(Na)NCHH2CH2N(Ts)CH2CH2N(Na)Ts + TsOCH2CH2OTs + → [(CH2CH2N(Ts)]3 + 2 NaOTs [(CH2CH2N(Ts)]3 + 3 H2O → [CH2CH2NH]3 + 3 HOTs

Application

Starting material for the synthesis of 1,4,7-trifunctionalized derivatives which have applications in metal complexation.
Possible reagent for compleximetric titrations with high cation-binding selectivity.

125262-43-3
4730-54-5
Synthesis of 1,4,7-Triazacyclononane from 1H-1,4,7-Triazonine, octahydro-1,4,7-tris(phenylmethyl)-

1,4,7-Triazacyclononane Preparation Products And Raw materials

Global( 216)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd
18192627656 1012@dideu.com China 3003 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29798 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29888 58
Accela ChemBio Inc.
+1-858-6993322 info@accelachem.com United States 19536 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39916 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63711 58
Fuxin Pharmaceutical
+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10297 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34571 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894 shawn@hirisunpharm.com CHINA 9923 58

View Lastest Price from 1,4,7-Triazacyclononane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,4,7-Triazacyclononane pictures 2024-08-12 1,4,7-Triazacyclononane
4730-54-5
US $1.00-1.50 / KG 1KG 99% 100000KG Shaanxi Dideu Medichem Co. Ltd
1,4,7-Triazacyclononane pictures 2024-04-02 1,4,7-Triazacyclononane
4730-54-5
US $0.00 / g 10g >95.00% 10g Xian confluore Biological Technology Co., Ltd.
1,4,7-Triazacyclononane pictures 2023-12-04 1,4,7-Triazacyclononane
4730-54-5
US $0.00-0.00 / kg 0.1kg 98% 100kg Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
OCTAHYDRO-1H-1,4,7-TRIAZONINE Octahydro-1H-1,4,7-triazonine, Triethylenetriamine 1,4,7-Triazacyclonomane TRIETHYLENETRIAMINE Triazacyclononanewhitextl 1,4,7-Triazacyclononane,97% 1,4,7-triazonane 1,4,7-Triazacyclononane hcl 1,4,7-triazonane trihydrochloride TACN 1,4,8-Triazacyclononane 1,4,7-TRIAZACYCLONONANE DOTA-d-Phe-Cys-Tyr-d-Trp-Lys-Thr-Cys-Thr 157715 1H-1,4,7-Triazonine, octahydro- Triazacyclononane 1,4,7-triazacyclononane (TACN) 4730-54-5 4370-54-5 Synthetic Reagents Crown Ethers Chelation/Complexation Compounds Achiral Nitrogen Cy-N organic amine