tert-butyl 4-(mercaptomethyl)piperidine-1-carboxylate
- CAS No.
- 581060-27-7
- Chemical Name:
- tert-butyl 4-(mercaptomethyl)piperidine-1-carboxylate
- Synonyms
- 1-Boc-4-(Mercaptomethyl);1-Boc-4-(MercaptoMethyl)piperidine;tert-butyl 4-(sulfanylmethyl)piperidine-1-carboxylate;tert-butyl 4-(mercaptomethyl)piperidine-1-carboxylate;4-Mercaptomethyl-piperidine-1-carboxylic acid tert-butyl ester;4-(Mercaptomethyl)-1-piperidinecarboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(mercaptomethyl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB42534222
- Molecular Formula:
- C11H21NO2S
- Molecular Weight:
- 231.35
- MDL Number:
- MOL File:
- 581060-27-7.mol
| Product description | Number | Pack Size | Price |
| 4-Mercaptomethylpiperidine-1-carboxylicacidtert-butylester | Z2886 | 250mg | $604 |
| tert-butyl4-(mercaptomethyl)piperidine-1-carboxylate 95% | 34306 | 1g | $920 |
| 4-Mercaptomethylpiperidine-1-carboxylicacidtert-butylester | Z2886 | 500mg | $951 |
| 1-Boc-4-(Mercaptomethyl)piperidine 97% | CD11100425 | 1g | $820 |
| tert-butyl4-(mercaptomethyl)piperidine-1-carboxylate 97% | AR00EJNY | 50mg | $111 |
| Boiling point | 316.9±15.0 °C(Predicted) |
|---|---|
| Density | 1.052 |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 10.23±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C11H21NO2S/c1-11(2,3)14-10(13)12-6-4-9(8-15)5-7-12/h9,15H,4-8H2,1-3H3 |
| InChIKey | VEPAXJUGIFPJNK-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(CS)CC1 |
tert-butyl 4-(mercaptomethyl)piperidine-1-carboxylate price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | Z2886 | 4-Mercaptomethylpiperidine-1-carboxylicacidtert-butylester | 581060-27-7 | 250mg | $604 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 34306 | tert-butyl4-(mercaptomethyl)piperidine-1-carboxylate 95% | 581060-27-7 | 1g | $920 | 2021-12-16 | Buy |
| AK Scientific | Z2886 | 4-Mercaptomethylpiperidine-1-carboxylicacidtert-butylester | 581060-27-7 | 500mg | $951 | 2021-12-16 | Buy |
| Crysdot | CD11100425 | 1-Boc-4-(Mercaptomethyl)piperidine 97% | 581060-27-7 | 1g | $820 | 2021-12-16 | Buy |
| Aaron Chemicals | AR00EJNY | tert-butyl4-(mercaptomethyl)piperidine-1-carboxylate 97% | 581060-27-7 | 50mg | $111 | 2021-12-16 | Buy |
tert-butyl 4-(mercaptomethyl)piperidine-1-carboxylate Chemical Properties,Uses,Production
Synthesis
![1-Piperidinecarboxylic acid, 4-[[(aminoiminomethyl)thio]methyl]-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/895126-44-0.gif)
895126-44-0
581060-27-7
A reaction was carried out with tert-butyl 4-((carbamoylimidothio)methyl)piperidine-1-carboxylate (1.2, 15 g, 1.00 eq., crude) as raw material with sodium hydroxide (2.2 g, 55.00 mmol, 1.00 eq.) in a mixture of methanol/water (1:2 v/v, 150 mL) under argon protection at 60 °C with stirring for 2 hours. After completion of the reaction, the reaction mixture was cooled to room temperature. The pH of the reaction solution was adjusted with 35% aqueous hydrochloric acid to 7. The reaction solution was extracted with ethyl acetate (3 x 50 mL) and the organic phases were combined. The organic phase was washed with saturated saline (2 x 50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether=1:8 v/v) to give 5.6 g of yellow oily product in 44% yield. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 4.13 (m, 2H), 2.69 (m, 2H), 2.46 (m, 2H), 1.82 (m, 2H), 1.50 (s, 9H), 1.32 (m, 1H), 1.18 (m, 2H) ppm.
References
[1] Patent: US2016/243100, 2016, A1. Location in patent: Paragraph 0078
tert-butyl 4-(mercaptomethyl)piperidine-1-carboxylate Preparation Products And Raw materials
tert-butyl 4-(mercaptomethyl)piperidine-1-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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