5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol
- CAS No.
- 59281-14-0
- Chemical Name:
- 5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol
- Synonyms
- 5-benzyloxy-4-hydroxy-2-hydroxymethylpyridine;5-(benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one;2-(hydroxymethyl)-5-(phenylmethoxy)-4(1H)-Pyridinone;4(1H)-Pyridinone, 2-(hydroxymethyl)-5-(phenylmethoxy)-;2-(hydroxymethyl)-5-[(phenylmethyl)oxy]-4-oxo-1,4-dihydropyridine
- CBNumber:
- CB42601180
- Molecular Formula:
- C13H13NO3
- Molecular Weight:
- 231.25
- MDL Number:
- MOL File:
- 59281-14-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one 97% | AK549013 | 1g | $49 |
| 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one 97% | CM253876 | 1g | $186 |
| 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one | 59281140 | 1g | $192.92 |
| 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one 97% | CD11098149 | 5g | $397 |
| 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one | 59281140 | 5g | $548.08 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Ark Pharm | AK549013 | 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one 97% | 59281-14-0 | 1g | $49 | 2021-12-16 | Buy |
| Chemenu | CM253876 | 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one 97% | 59281-14-0 | 1g | $186 | 2021-12-16 | Buy |
| Alichem | 59281140 | 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one | 59281-14-0 | 1g | $192.92 | 2021-12-16 | Buy |
| Crysdot | CD11098149 | 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one 97% | 59281-14-0 | 5g | $397 | 2021-12-16 | Buy |
| Alichem | 59281140 | 5-(Benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one | 59281-14-0 | 5g | $548.08 | 2021-12-16 | Buy |
5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Chemical Properties,Uses,Production
Definition
ChEBI: 5-(benzyloxy)-2-(hydroxymethyl)-1,4-dihydropyridin-4-one is an aromatic ether.
Synthesis
15771-06-9
59281-14-0
5-(Benzyloxy)-2-(hydroxymethyl)-4H-pyran-4-one (53.2 g, 229 mmol) was used as starting material and suspended in a mixed solution of industrial methylated alcohol (IMS, 75 mL) and water (400 mL). To this suspension, NH4OH solution (400 mL) was slowly added at 70 °C and the reaction was continuously stirred for 18 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently diluted with water (400 mL) and stirring was continued for 30 minutes. The resulting solid product was collected by filtration and dried under vacuum to afford the target compound 5-(benzyloxy)-2-(hydroxymethyl)pyridin-4(1H)-one (10) as a light brown solid (42.5 g, 80% yield). The product was analyzed by LC-MS showing (M-H)+ = 232. 1H NMR (300 MHz, DMSO-d6) data were as follows: δ 11.08 (br s, 1H), 7.51-7.28 (m, 6H), 6.16 (br s, 1H), 5.56 (br s, 1H), 5.01 (s, 2H), 4.34 (s, 2H).
References
[1] Dalton Transactions, 2016, vol. 45, # 15, p. 6517 - 6528
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2669 - 2684
[3] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 150
[4] Patent: CN106986819, 2017, A. Location in patent: Paragraph 0024-0026; 0028-0030
[5] Patent: CN106986820, 2017, A. Location in patent: Paragraph 0031-0032
5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Preparation Products And Raw materials
5-(benzyloxy)-2-(hydroxyMethyl)pyridin-4-ol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
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| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
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| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 52678 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
