CYT387,MsOH salt
- CAS No.
- 1056636-07-7
- Chemical Name:
- CYT387,MsOH salt
- Synonyms
- CS-1290;CYT387,MsOH salt;CYT387 (Mesylate);Momelotinib mesylate);CYT387 mesylate (CYT 387 mesylate;MOMELOTINIB MESYLATE (CYT387 MESYLATE);CYT 387 MESYLATE;CYT-387 MESYLATE;MOMELOTINIB MESYLATE
- CBNumber:
- CB42627744
- Molecular Formula:
- C24H26N6O5S
- Molecular Weight:
- 510.57
- MDL Number:
- MFCD18251579
- MOL File:
- 1056636-07-7.mol
CYT387,MsOH salt price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Biorbyt Ltd | orb611828 | CYT387 mesylate | 1056636-07-7 | 10mg | $238 | 2021-12-16 | Buy |
Biorbyt Ltd | orb611828 | CYT387 mesylate | 1056636-07-7 | 50mg | $508.3 | 2021-12-16 | Buy |
Biorbyt Ltd | orb611828 | CYT387 mesylate | 1056636-07-7 | 100mg | $657.9 | 2021-12-16 | Buy |
Crysdot | CD31004689 | CYT387Mesylate 98+% | 1056636-07-7 | 5mg | $60 | 2021-12-16 | Buy |
DC Chemicals | DC24066 | CYT387mesylate >98% | 1056636-07-7 | 10mg | $84 | 2021-12-16 | Buy |
CYT387,MsOH salt Chemical Properties,Uses,Production
Description
Momelotinib Mesylate (CYT387 Mesylate) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, appr 10-fold selectivity versus JAK3. JAK1|11 nM (IC50)|JAK2|18 nM (IC50)|JAK3|155 nM (IC50)
Momelotinib Mesylate is an inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, appr 10-fold selectivity versus JAK3. Momelotinib inhibits the proliferation of parental Ba/F3 cells (Ba/F3-wt) stimulated by IL-3 with IC50 of 1400 nM. Furthermore, Momelotinib also causes the inhibition of cell proliferation in cell lines constitutively activated by JAK2 or MPL signaling, including Ba/F3-MPLW515L cells, CHRF-288-11 cells and Ba/F3-TEL-JAK2 cells with IC50 of 200 nM, 1 nM and 700 nM, respectively. In addition, Momelotinib has been shown to inhibit erythroid colony growth in vitro from JAK2V617F-positive PV patients with similar potency with IC50 of 2 μM-4 μM[1]. Momelotinib inhibits PI3K/AKT and Ras/MAPK signaling induced by IL-6 and IGF-1. Moreover, Momelotinib induces apoptosis as a single agent and synergizes with the conventional anti-MM therapies bortezomib and melphalan in primary multiple myeloma (MM) cells[2].
In a murine MPN model, Momelotinib normalizes white cell counts, hematocrit, spleen size, and restores physiologic levels of inflammatory cytokines[3].
References
[1]. Pardanani A, et al. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia, 2009, 23(8), 1441-1445. [2]. Monaghan KA, et al. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia, 2011, 25(12), 1891-1899. [3]. Tyner JW, et al. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood, 2010, 115(25), 5232-5240.
CYT387,MsOH salt Preparation Products And Raw materials
Raw materials
Preparation Products
CYT387,MsOH salt Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
Intelligence Pharm Science(Shanghai) Co., Ltd. | 021-57898186 | China | 449 | 55 | |
SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 18108052721 | 2850505130@qq.com | China | 5182 | 58 |