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RP107

RP107 structure

CAS No.: 496864-16-5

Chemical Name:: RP107

Synonyms: RP107;ALOISINE A;ALOISINE A RP107;Aloisine A - CAS 496864-16-5 - Calbiochem;4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol;4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL;Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-;7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine;7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE;7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE

CBNumber:: CB4265483

Molecular Formula:: C16H17N3O

Molecular Weight:: 267.33

MDL Number:: MFCD04973541

MOL File:: 496864-16-5.mol

MSDS File:: SDS

Last updated:2023-05-04 17:34:39

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RP107 Properties

Melting point	281-283°C
Density	1.227
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Yellow solid
pka	9.67±0.15(Predicted)
color	Light Orangish Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P305+P351+P338
Risk Statements	36/37/38
Safety Statements	26-36/37

RP107 price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	128125	Aloisine A - CAS 496864-16-5 - Calbiochem A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects.	496864-16-5	5mg	$187	2024-03-01	Buy
TRC	A575450	AloisineARP107	496864-16-5	100mg	$1175	2021-12-16	Buy
Biosynth Carbosynth	FA17320	Aloisine A RP107	496864-16-5	1mg	$65	2021-12-16	Buy
Biosynth Carbosynth	FA17320	Aloisine A RP107	496864-16-5	2mg	$100	2021-12-16	Buy
Biosynth Carbosynth	FA17320	Aloisine A RP107	496864-16-5	5mg	$200	2021-12-16	Buy

Product number	Packaging	Price	Buy
128125	5mg	$187	Buy
A575450	100mg	$1175	Buy
FA17320	1mg	$65	Buy
FA17320	2mg	$100	Buy
FA17320	5mg	$200	Buy

RP107 Chemical Properties,Uses,Production

Chemical Properties

Yellow solid

Uses

A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,

Definition

ChEBI: 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)-1-cyclohexa-2,5-dienone is a member of quinomethanes.

General Description

A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 150 nM, 120 nM, 400 nM, and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively), glycogen synthase kinase-3 (GSK-3; IC₅₀ = 500 nM and 1.5 μM for GSK-3α, GSK-3β, respectively), and c-Jun N-terminal kinase (JNK; IC₅₀ = ~ 3 - 10 μM). It inhibits several other enzymes (CK1, CK2, MAPKK, PKA, PKG, PKCs, and c-raf) poorly (IC₅₀ ≥ 100 μM). Shown to arrest cells in both G₁ and G₂ phases (IC₅₀ = 7 μM and 10.5 μM for undifferentiated human teratocarcinoma cells NT2 and differentiated postmitotic neurons hNT, respectively). Shown to selectively stimulate CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin (Cat. No. 344270) with high affinity (EC₅₀ = 150 nM, 140 nM and 111 nM, respectively).

Biochem/physiol Actions

EC50 = 150 nM, 140 nM and 111 nM, in stimulating CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin, respectively

RP107 Preparation Products And Raw materials

Raw materials

Preparation Products

RP107 Suppliers

Global( 59)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4664	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Shanghai Paulshine Chemical Co., Ltd.	+86-021-37788663		China	186	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Amadis Chemical Company Limited	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Shanghai Paulshine Chemical Co., Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50

496864-16-5(RP107)Related Search:

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Alsterpaullone PTH-RP (107-111) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT),PTH-RP (107-111) (HUMAN, RAT) PTH-RP (107-111) AMIDE (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT),PTH-RP (107-111) AMIDE (HUMAN, RAT) RP107 RP106

2-PHENYL-4,7-DIAZAINDOLE

1of3

RP107 4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL ALOISINE A ALOISINE A RP107 7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE 7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-β]pyrazine 4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol 7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine Aloisine A - CAS 496864-16-5 - Calbiochem Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)- 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-1-one 4-(7-butyl-l,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-l-one 496864-16-5 All Inhibitors Inhibitors Protein Kinase Inhibitors and Activators Aromatics Heterocycles