ChemicalBook >> CAS DataBase List >>BMS 833923
BMS 833923
- CAS No.
- 1059734-66-5
- Chemical Name:
- BMS 833923
- Synonyms
- XL139;CS-944;XL-139;XL 139;BMS 833923;BMS-833923 (XL-139);BMS 833923 USP/EP/BP;BMS 833923; BMS833923; XL-139; XL139; XL 139;N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide;Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-
- CBNumber:
- CB42658184
- Molecular Formula:
- C30H27N5O
- Molecular Weight:
- 473.57
- MDL Number:
- MFCD25976660
- MOL File:
- 1059734-66-5.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:01:57
| Density | 1.252±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≥47.4 mg/mL in DMSO; insoluble in H2O; ≥5.14 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| pka | 13.42±0.70(Predicted) |
| FDA UNII | 41J7ZJ239R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| NFPA 704 |
|
BMS 833923 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16240 | BMS 833923 ≥98% | 1059734-66-5 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 16240 | BMS 833923 ≥98% | 1059734-66-5 | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16240 | BMS 833923 ≥98% | 1059734-66-5 | 25mg | $194 | 2024-03-01 | Buy |
| Cayman Chemical | 16240 | BMS 833923 ≥98% | 1059734-66-5 | 50mg | $317 | 2024-03-01 | Buy |
| TRC | B596320 | BMS833923 | 1059734-66-5 | 100mg | $395 | 2021-12-16 | Buy |
BMS 833923 Chemical Properties,Uses,Production
Description
Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.
Uses
BMS 833923 is an antagonist of smoothened, a key hedgehog (Hh) pathway regulator.
BMS 833923 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 95)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27894 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
1059734-66-5(BMS 833923)Related Search:
BMS 833923
XL 139
XL139
XL-139
BMS-833923 (XL-139)
N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide
Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-
BMS 833923 N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide
N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide BMS-833923
BMS 833923; BMS833923; XL-139; XL139; XL 139
CS-944
BMS 833923 USP/EP/BP
1059734-66-5
Inhibitors