4-Hydroxyalternariol
- CAS No.
- 959417-21-1
- Chemical Name:
- 4-Hydroxyalternariol
- Synonyms
- 4-Hydroxyalternariol;Hydroxyalternariol, 4-;Alternariol Impurity 18;3,4,7,9-tetrahydroxy-1-methylbenzo[c]chromen-6-one;3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one;6H-Dibenzo[b,d]pyran-6-one, 3,4,7,9-tetrahydroxy-1-methyl-
- CBNumber:
- CB42720810
- Molecular Formula:
- C14H10O6
- Molecular Weight:
- 274.23
- MDL Number:
- MOL File:
- 959417-21-1.mol
4-Hydroxyalternariol price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23636 | 4-hydroxy Alternariol >95% | 959417-21-1 | 500μg | $144 | 2024-03-01 | Buy |
| Cayman Chemical | 23636 | 4-hydroxy Alternariol >95% | 959417-21-1 | 1mg | $274 | 2024-03-01 | Buy |
| Cayman Chemical | 23636 | 4-hydroxy Alternariol >95% | 959417-21-1 | 5mg | $931 | 2024-03-01 | Buy |
| AK Scientific | 4375EF | 3,4,7,9-Tetrahydroxy-1-methylbenzo[c]chromen-6-one | 959417-21-1 | 5mg | $1135 | 2021-12-16 | Buy |
4-Hydroxyalternariol Chemical Properties,Uses,Production
Description
4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 μM under cell-free conditions.
Uses
4-Hydroxy Alternariol is a derivative of Alternariol (A575760). Alternariol is an alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks.
Uses
4-Hydroxyalternariol is the fully demethylated tetraphenol analogue of the benzopyranone graphislactones. Hydroxyalternariol was isolated as a major co-metabolite of a graphislactone A-producing fungus. Hydroxyalternariol has not previously been available for study and no bioactivity has been reported to date.
4-Hydroxyalternariol Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxyalternariol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Chengdu RunZeBenTu Chemical Co., Ltd | 13096311329 028-88469284 616445927 | 616445927@qq.com | China | 2876 | 50 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55896 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |