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LOFEPRAMINE HYDROCHLORIDE

LOFEPRAMINE HYDROCHLORIDE Structure
LOFEPRAMINE HYDROCHLORIDE structure
CAS No.
26786-32-3
Chemical Name:
LOFEPRAMINE HYDROCHLORIDE
Synonyms
db-2182;WHR 2908A;WHR-2908A;ropylaminehcl;LOFEPRAMINE HCL;acetophenonehcl;leo640hydrochloride;iopraminehydrochloride;lopraminehydrochloride;clopepraminehydrochloride
CBNumber:
CB4351274
Molecular Formula:
C26H28Cl2N2O
Molecular Weight:
455.42
MDL Number:
MFCD00941486
MOL File:
26786-32-3.mol
MSDS File:
SDS
Last updated:2023-05-04 17:34:36
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LOFEPRAMINE HYDROCHLORIDE Properties

Melting point 152-154°
Flash point 9℃
storage temp. 2-8°C
solubility DMSO: ~24 mg/mL
form solid
color off-white
FDA UNII Z24K96F991

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H290-H301+H311+H331-H370
Precautionary statements  P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235
Hazard Codes  Xn
Risk Statements  22-37-53
Safety Statements  22-24/25-26-28-36/37/39-38
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  AM6485000
Toxicity LD50 in mice, rats (mg/kg): >2500, >1000 orally; 920, >1000 i.p.; >1000, >1000 s.c. (Eriksoo, Rohte)

LOFEPRAMINE HYDROCHLORIDE price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0006780 LOFEPRAMINE HYDROCHLORIDE 95.00% 26786-32-3 5MG $779.45 2021-12-16 Buy
AHH MT-53291 Lofepramine hydrochloride 98% 26786-32-3 0.025g $380 2021-12-16 Buy
Product number Packaging Price Buy
API0006780 5MG $779.45 Buy
MT-53291 0.025g $380 Buy

LOFEPRAMINE HYDROCHLORIDE Chemical Properties,Uses,Production

Originator

Gamonil,E. Merck

Uses

Monoamine reuptake inhibitor; tricyclic antidepressant.

Uses

Lofepramine Hydrochloride is a tricyclic anti-depressent drug. Potent inhibitor of noradenaline uptake.

Definition

ChEBI: Lofepramine hydrochloride is a hydrochloride. It has a role as an antidepressant. It contains a lofepramine.

Manufacturing Process

9.8 parts of 10,11-dihydro-5H-dibenzo[b,f]azepine are dissolved in 10 parts of dry toluene and 3.1 parts of sodium amide are added and the mixture is refluxed and stirred for four hours. A solution of 13.5 parts of 1-(4- chlorophenyl)-2-[(3-chloropropyl)methylamino]ethanone in 20 parts of dry toluene is added dropwise and the mixture is stirred and refluxed for eight hours.
After cooling to room temperature water is carefully added to the reaction mixture and the toluene solution is extracted with water to which hydrochloric acid is added so that the aqueous phase obtains the pH-value of 5. The aqueous extract is discarded and the toluene phase is evaporated to dryness in vacuum. The residue is dissolved in 50 parts of methanol. Hydrogen gas is introduced to give the crystalline hydrochloride 1-(4-chlorophenyl)-2-((3- (10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)methylamino)ethanone; MP: 154°-156°C. The hydrochloride may be removed by adding an equivalent of any base (triethyl amine, sodium hydroxide and so on).

Therapeutic Function

Antidepressant

LOFEPRAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Sodium amide Iminodibenzyl

Preparation Products

LOFEPRAMINE HYDROCHLORIDE Suppliers

Global( 36)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Xi'an ZB Biotech Co.,Ltd 		+8618591943808 sales01@xazbbio.com China 816 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9626 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52861 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 50000 58
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2127 70
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9625 58
Hangzhou ChangCun Biotechnology Co., Ltd. 0571-; 13567100326 158848739@qq.com China 108 50
Supplier Advantage
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Xi'an ZB Biotech Co.,Ltd 		58
Finetech Industry Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Alfa Chemistry 		58
GIHI CHEMICALS CO.,LIMITED 		58
LGM Pharma 70
Finetech Industry Limited 58
Hangzhou ChangCun Biotechnology Co., Ltd. 50

26786-32-3(LOFEPRAMINE HYDROCHLORIDE)Related Search:

Venlafaxine hydrochloride Duloxetine hydrochloride enteric-coated tablets Imipramine hydrochloride DESIPRAMINE HYDROCHLORIDE LOFEPRAMINE HYDROCHLORIDE
LOFEPRAMINE

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N-(4-CHLOROBENZOYLMETHYL)-3-(10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPIN-5-YL)-N-METHYLPROPYLAMINE HYDROCHLORIDE LOFEPRAMINE HCL LOFEPRAMINE HYDROCHLORIDE 4’-chloro-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl)methylamino) acetophenone,4’-chloro-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl)m acetophenonehcl clopepraminehydrochloride db-2182 f)azepine,5-(3-((p-chlorobenzoylmethyl)-n-methylamino)propyl)-5h-dibenz( iopraminehydrochloride leo640hydrochloride lopraminehydrochloride n-methyl-n-(4’-chlorophenacyl)-3-(10,11-dihydro-5h-dibenzo(b,f)azepin-5-yl)p ropylaminehcl 1-(4-chlorophenyl)-2-[[3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]methylamino]ethan-1-one monohydrochloride Lofepramine Hydrochloride DISCONTINUED, UNSTABLE, OFFER L469380 lofepramine hydrochloride (form A) WHR 2908A WHR-2908A 26786-32-3 C26H27ClN2OHCl C26H27ClN2OClH C26H28Cl2N2O