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Eliprodil

Eliprodil Structure
Eliprodil structure
CAS No.
119431-25-3
Chemical Name:
Eliprodil
Synonyms
ELIPRODIL;SL 820715;1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol;α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol;1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol;α-(4-Chlorophenyl)-4-[(4-fluorophenyl)Methyl]-1-piperidineethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-;ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL
CBNumber:
CB4373759
Molecular Formula:
C20H23ClFNO
Molecular Weight:
347.85
MDL Number:
MFCD00866651
MOL File:
119431-25-3.mol
Last updated:2023-09-04 15:50:00
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Eliprodil Properties

Boiling point 474.1±35.0 °C(Predicted)
Density 1.205±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: ~17 mg/mL
form solid
pka 13.99±0.20(Predicted)
color white
FDA UNII YW62A6TW29

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H319-H410
Precautionary statements  P273-P305+P351+P338-P501
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN 3077 9/PG 3
WGK Germany  3
NFPA 704
0
2 0

Eliprodil price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E2031 Eliprodil ≥98% (HPLC), powder 119431-25-3 10mg $189 2024-03-01 Buy
Sigma-Aldrich 5.04539 Eliprodil - CAS 119431-25-3 - Calbiochem 119431-25-3 10mg $90 2024-03-01 Buy
Sigma-Aldrich E2031 Eliprodil ≥98% (HPLC), powder 119431-25-3 50mg $660 2023-01-07 Buy
Cayman Chemical 18398 Eliprodil ≥98% 119431-25-3 5mg $61 2024-03-01 Buy
Cayman Chemical 18398 Eliprodil ≥98% 119431-25-3 1mg $32 2023-01-06 Buy
Product number Packaging Price Buy
E2031 10mg $189 Buy
5.04539 10mg $90 Buy
E2031 50mg $660 Buy
18398 5mg $61 Buy
18398 1mg $32 Buy

Eliprodil Chemical Properties,Uses,Production

Description

N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents. It is selective for NR2B subunit-containing receptors (IC50 = 1 μM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits. Eliprodil also avidly binds σ1 and σ2 sites (Kis = 0.013 and 0.63 μM, respectively). It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion. Eliprodil can also have proarrhythmic actions in hearts under normal conditions.

Uses

Eliprodil is a noncardiac drug with neuroprotective properties. It is also a N-Methyl-D-aspartate receptor (NMDAR) antagonist.

Definition

ChEBI: Eliprodil is a racemate comprising equimolar amounts of (R)- and (S)-eliprodil. It is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist and an anti-ischaemic agent that exhibits neuroprotective properties. It has a role as a geroprotector, a NMDA receptor antagonist, a neuroprotective agent and a calcium channel blocker. It contains a (R)-eliprodil and a (S)-eliprodil.

Biological Activity

Eliprodil (SL-820715) is a non-competitive, NR2B-selective NMDA antagonist with IC50 of 1 μM. Its IC50 is greater than 100 μM for receptors containing NR2A and NR2C.

Biological Activity

Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC 50 values are 1, > 100 and > 100 μ M respectively). Also σ 1 ligand (K i = 0.013 μ M). Antagonizes neuronal voltage-gated Ca 2+ channels and selectively inhibits the rapid component of the delayed rectifier K + current (I Kr ). Neuroprotective.

storage

+4°C (desiccate)

Eliprodil Preparation Products And Raw materials

Raw materials

Preparation Products

Eliprodil Suppliers

Global( 112)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Alfa Chemistry 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58

View Lastest Price from Eliprodil manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL pictures 2019-09-02 ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL
119431-25-3
 US $1.00-1.00 / KG 1KG 98% 1lg; 2kg; 5kg; 10kg; 100kg Career Henan Chemical Co

Eliprodil Spectrum

Eliprodil(119431-25-3)1HNMR

119431-25-3(Eliprodil)Related Search:

7-Hydroxyisoflavone (7β,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid γ-Lactone Methyl Ester Serotonin hydrochloride (R)-Eliprodil (S)-Eliprodil
4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE 4-(4-FLUOROBENZYL)PIPERIDINE HYDROCHLORIDE 4-(4'-Fluorobenzyl)piperidine Eliprodil

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SL 820715 ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL ELIPRODIL α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol SL 820715, α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol (+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol 1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol 1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]- α-(4-Chlorophenyl)-4-[(4-fluorophenyl)Methyl]-1-piperidineethanol 1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol (+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol 119431-25-3 C20H23ClFNO Cell Biology BioChemical Cell Signaling and Neuroscience Ionotropic Glutamate Receptor Modulators Ion Channels Ligand-Gated Ion Channels Inhibitors Glutamate receptor Neuroprotective agent.