CLEMIZOLE
- CAS No.
- Chemical Name:
- CLEMIZOLE
- Synonyms
- CLEMIZOLE
- CBNumber:
- CB4383666
- Molecular Formula:
- C19H20ClN3
- Molecular Weight:
- 325.84
- MDL Number:
- MFCD00051434
- MOL File:
- Mol file
| FDA UNII | T97CB3796L |
|---|
CLEMIZOLE Chemical Properties,Uses,Production
Originator
Allercur,Roerig,US,1960
Manufacturing Process
From 13.1 g of N-p-chlorobenzyl-2-nitroaniline (MP 110°C, obtained in the
form of orange-red needles, from o-nitrochlorobenzene and pchlorobenzylamine by reaction for 3 hours at 150°C) by reduction with Raneynickel and hydrogen, in which reaction the substance may be suspended in
methanol or dissolved in methanol-ethyl acetate at normal pressure and at
about 40°C with combination of the theoretical quantity of hydrogen, 12.2 g
are obtained of o-amino-N-p-chlorobenzylaniline, which after recrystallization
from aqueous methanol has a MP of 90°C.
8 g of o-amino-N-p-chlorobenzylaniline and 2.8 g of pyridine are dissolved in
dry ether and reacted with an ethereal solution of 3.9 g of chloracetyl chloride
with cooling in a mixture of ice and common salt. 8 g of N-p-chlorobenzyl-N'-
chloracetyl-o-phenylene diamine are obtained which can be worked up in the
form of the crude product and, in the slightly colored form, has a MP of
130°C.
7.6 g of this compound are boiled with 3.9 g of pyrrolidine in 70 cc of toluene
for some hours under reflux. After extraction by shaking with water and
treatment with hydrochloric acid the hydrochloride is produced of N-pchlorobenzyl-N'-pyrrolidylacetyl-o-phenylene diamine together with some 1-pchlorobenzyl-2-N-pyrrolidylmethyl-benzimidazole. The former, after
recrystallization from butanol, melts with foaming at 205°C, the latter, after
recrystallization from butanol melts at 239°C to 241°C, and is in the form of
white microscopic rods. Boiling in nitrobenzene converts the former compound
into the latter.
Therapeutic Function
Antihistaminic
CLEMIZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
CLEMIZOLE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Lianke Biotechnology Co., Ltd. | -- | CHINA | 6349 | 58 | |
| Beijing Luyuan Bird Biotechnology Co., Ltd. | -- | 15810802415@139.com | CHINA | 6757 | 58 |
| Shanghai Haoran Biotechnology Co., Ltd. | -- | 470003480@QQ.COM | CHINA | 6968 | 58 |
| Beijing Dongge Boye Biotechnology Co., Ltd. | -- | 1861586486@qq.com | CHINA | 6652 | 58 |
| Rhenbo (Shanghai) Biochemical Technology Co., Ltd. | -- | CHINA | 6334 | 58 | |
| Shanghai Qincheng Biological Technology Co., Ltd. | -- | shqcsw01@163.com | CHINA | 6369 | 58 |
| Shanghai Qiming Biological Technology Co., Ltd. | -- | CHINA | 6503 | 58 | |
| Beijing Lebo Biotechnology Co., Ltd. | -- | CHINA | 6057 | 58 | |
| Guangzhou Weijia Technology Co., Ltd. | -- | WHIGA22@126.COM | CHINA | 6748 | 58 |
| Xiamen Huijia Biological Technology Co., Ltd. | -- | CHINA | 6979 | 58 |