ChemicalBook >> CAS DataBase List >>4-Cloromethyl-5-methyl-1,3-dioxol-2-one
4-Cloromethyl-5-methyl-1,3-dioxol-2-one
- CAS No.
- 80841-78-7
- Chemical Name:
- 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
- Synonyms
- DMDO-CL;4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE;Olmesartan impurity;4-ChloroMethyl-5-Methyl-1;AZATMint-C;Olmesartan Impurity 3;Olmesartan Impurity 57;Olmesartan Medoxomil IMP;4,5- dinmethyl-1,3-dioxol-2-;4-Chloromethyl-5-Methyl-1,3-Di
- CBNumber:
- CB4416605
- Molecular Formula:
- C5H5ClO3
- Molecular Weight:
- 148.54
- MDL Number:
- MFCD07787494
- MOL File:
- 80841-78-7.mol
Last updated:2024-04-08 17:36:13
| Boiling point | >90℃/2mm |
|---|---|
| Density | 1.362±0.06 g/cm3(Predicted) |
| refractive index | 1.4760-1.4820 |
| Flash point | 129 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | liquid |
| Specific Gravity | 1.36 |
| color | Colorless to Light yellow to Light orange |
| BRN | 4798926 |
| InChI | InChI=1S/C5H5ClO3/c1-3-4(2-6)9-5(7)8-3/h2H2,1H3 |
| InChIKey | QCLFSYYUWPUWQR-UHFFFAOYSA-N |
| SMILES | CC1=C(OC(=O)O1)CCl |
| CAS DataBase Reference | 80841-78-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335-H301 | |||||||||
| Precautionary statements | P280a-P301+P310a-P405-P501a-P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
4-Cloromethyl-5-methyl-1,3-dioxol-2-one price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1882 | 4-Chloromethyl-5-methyl-1,3-dioxol-2-one >94.0%(GC) | 80841-78-7 | 5g | $85 | 2024-03-01 | Buy |
| TCI Chemical | C1882 | 4-Chloromethyl-5-methyl-1,3-dioxol-2-one >94.0%(GC) | 80841-78-7 | 25g | $312 | 2024-03-01 | Buy |
| Alfa Aesar | H55735 | 4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97% | 80841-78-7 | 1g | $56.65 | 2024-03-01 | Buy |
| Alfa Aesar | H55735 | 4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97% | 80841-78-7 | 5g | $189.65 | 2024-03-01 | Buy |
| Alfa Aesar | H55735 | 4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97% | 80841-78-7 | 250mg | $19.3 | 2023-06-20 | Buy |
4-Cloromethyl-5-methyl-1,3-dioxol-2-one Chemical Properties,Uses,Production
Description
4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a useful branch side chain for synthetic penicillin esters such as Lenampicillin, Mecillinam, etc. It can improve the stability and absorption of drugs, increase biological activity, and reduce side effects. It is also used to prepare amine drugs, such as Norfloxacin prodrug. In the prior art, the primary method for synthesizing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a chlorination reaction of chlorine gas or N-chlorosuccinimide.
Chemical Properties
Colorless to Light yellow to Light orange clear liquid or Pale Yellow Oil.
Uses
4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). It is also used in the preparation of prodrugs of ampicillin.
Preparation
4,5-dimethyl-1,3-dioxole-2-ketone (DMDO) is used as raw material, taking sulfonic acid chloride as a chlorinating agent. The reaction is reat under the effect of a catalyzer in organic solvent and reacts for 1-5 hours to obtain target product 4-Cloromethyl-5-methyl-1,3-dioxol-2-one.
4-Cloromethyl-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials
Global( 607)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xinxiang Hongqi District Houyuan Trading Co.,Ltd | +86-0373-3695376 +86-13937349994 | HYJM@houyuanjm.com | China | 300 | 58 |
| Zhuhai Hairuide Bioscience and Technology Co., Ltd | +8618928027945 | sales3@zhhairuide.com | China | 97 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12468 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18219 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales01@airuikechemical.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15956 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21688 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
View Lastest Price from 4-Cloromethyl-5-methyl-1,3-dioxol-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-08 | 4-cloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | |
 |
2024-03-28 | 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one
80841-78-7
|
US $0.00 / kg | 25kg | 98% | Inquiry | PNP Biotech Co. Ltd | |
 |
2024-01-22 | 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7
|
US $8.00-0.80 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 4-cloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one
80841-78-7
- US $0.00 / kg
- 98%
- PNP Biotech Co. Ltd
-
- 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
80841-78-7
- US $8.00-0.80 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
80841-78-7(4-Cloromethyl-5-methyl-1,3-dioxol-2-one)Related Search:
(5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl Chloride
4-(chloroMethyl)-5-Methyl-1,3-dioxol-2-oneSynonyMs
1,3-Dioxol-2-one, 4-(chloromethyl)-5-methyl-
4-Cloromethyl-5-methyl-1,3-dioxol-2-one
4-CloroMethyl-5-Methyl-1,3-dioxol-2-one (DMDO-Cl)
OlMesartan IMpurity (4-(ChloroMethyl)-5-Methyl-1,3-Dioxol-2-one)
4- chloroMethyl-5- Methyl-1,3- two oxygenheterocyclicpentadiene-2- ketone
-5--1,3- two4-chloroMethylMethylcyclopentene-2- ketoneheterocyclic oxygen
4-ChloroMethyl-5-Methyl-l,3-dioxocyclopenten-2–one
DMDO-CL: 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
Olmesartan Medoxomil IMP
4-( Cyclomethyl carbonyl ) -5 - methyl – 1,3-dioxol-2-one ( OLM 45 )
4-CHLOROMETHYL-5-METHYL-2-OXO-1,3-DIOXOLE
4-CHLOROMETHYL-5-METHYL-1,3-DIOXOLEN-2-ONE
DMDO CL (4-METHYL-5-CHLOROMETHYL-1,3-DIOXOL-2-ONE)
4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One(Dmdo-Cl)
4-Chloromethyl-5-Methyl-1,3-Dioxocyclopenten-2-one
4-Chloromethyl-5-methyl-2H-1,3-dioxol-2-one
4-Choromethyl-5-methyl-2-oxo-1,3-dioxole
4-Chloromethyl-5-Methyl-1,3-Di
4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-3-ONE
4-methyl-5-chloro methyl-1,3-dioxol-2-one
4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE (INTERMEDIATE OF OLMESARTAN MEDOXOMIL)
4-Chloromethyl-5-methyl-1,3-dioxol-2-on
4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE HPLC 95%
4-Methyl-5-(chloromethyl)-1,3-dioxole-2-one
4-chloroMethyl-5-Methyl-1,3-dioxdene-2-one
Olmesartan Medoxomil Impurity 5
Olmesartan Medoxomil Impurity 56
4-Cloromethyl-5-methyl-1,3-dioxol-2-one in stock Factory
Olmesartan Impurity 3
AZATMint-C
Olmesartan Impurity 57
4-chloromethyl-5-methyl-1,3-Dioxol-2-oneQ: What is
4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the CAS Number of
4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the storage condition of
4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What are the applications of
4-chloromethyl-5-methyl-1,3-Dioxol-2-one
Olmesartan Medoxomil EP Impurity
4-Cloromethyl-5-methyl-1,3-dioxol-2-one ISO 9001：2015 REACH
Olmesartan Chloromethyl Impurity
4-Chloromethyl-5-methyl-1,3-dioxol-2-one >
Olmesartan Medoxomil Impurity 5
(4-(Chloromethyl)-5-methyl-1,3-Dioxol-2-one)
DMDO-CL
Olmesartan impurity
4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE
4-ChloroMethyl-5-Methyl-1
4-CHLORO METHYL-5-METHYL-1,3-DAIOXOL,2-ONE(DMDO.CL)
4,5- dinmethyl-1,3-dioxol-2-
4-ChlDMDO-Cloromethyl-5-methyl-1,3-dioxol-2-one
4-Chloromethyl-5-methyl-1,3-Dioxole -2-one (DMDO CL)
Olmesartan Medoxomil Impurity 5
(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Chloride
80841-78-7
C5H5ClO3
C5H5O3Cl
Carbonates
Carbonyl Compounds
Organic Building Blocks
Pharmaceutical Intermediates
INTERMEDIATESOF
Chemical intermediate for Olmesartane