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Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate structure

CAS No.: 3641-14-3

Chemical Name:: Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

Synonyms: Asciminib Impurity 21;5-AMINO-1H-1 2 4-TRIAZOLE-3-CARBOXYLIC;3-Amino-5-(methoxycarbonyl)-1,2,4-triazole;Methyl 5-aMino-1,2,4-triazole-3-carboxylate;Methyl 3-aMino-1,2,4-triazole-5-carboxylate;ethyl 5-aMino-1H-1,2,4-triazole-3-carboxylate;Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate;Methyl 5-aMino-2H-1,2,4-triazole-3-carboxylate;methyl 3-azanyl-1H-1,2,4-triazole-5-carboxylate;2,4-triazole-3-carboxylicacid,5-amino-1h-methylester

CBNumber:: CB4498603

Molecular Formula:: C4H6N4O2

Molecular Weight:: 142.12

MDL Number:: MFCD00297193

MOL File:: 3641-14-3.mol

MSDS File:: SDS

Last updated:2025-08-08 17:45:00

Product description	Number	Pack Size	Price
5-Amino-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester 96%	573787	1g	$47.18
Methyl5-amino-1h-1,2,4-triazole-3-carboxylate	M328680	500mg	$65
Methyl 5-amino-1h-1,2,4-triazole-3-carboxylate	455626	100mg	$305
Methyl5-amino-1h-1,2,4-triazole-3-carboxylate	M328680	100mg	$45
Methyl 5-amino-4H-[1,2,4]triazole-3-carboxylate 95+%	073914	1g	$278
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Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Properties

Melting point	218-222 °C (lit.)
Boiling point	379.0±25.0 °C(Predicted)
Density	1.505±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	8.92±0.40(Predicted)
form	Crystalline Powder
color	White
InChI	InChI=1S/C4H6N4O2/c1-10-3(9)2-6-4(5)8-7-2/h1H3,(H3,5,6,7,8)
InChIKey	MGRNUMFYRVKLEO-UHFFFAOYSA-N
SMILES	N1C(N)=NC(C(OC)=O)=N1
CAS DataBase Reference	3641-14-3(CAS DataBase Reference)
FDA UNII	33BDL3S99S
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P280
Hazard Codes	Xi
Risk Statements	43
Safety Statements	36/37
WGK Germany	3
HazardClass	IRRITANT

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	573787	5-Amino-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester 96%	3641-14-3	1g	$47.18	2025-07-31	Buy
TRC	M328680	Methyl5-amino-1h-1,2,4-triazole-3-carboxylate	3641-14-3	500mg	$65	2021-12-16	Buy
Usbiological	455626	Methyl 5-amino-1h-1,2,4-triazole-3-carboxylate	3641-14-3	100mg	$305	2021-12-16	Buy
TRC	M328680	Methyl5-amino-1h-1,2,4-triazole-3-carboxylate	3641-14-3	100mg	$45	2021-12-16	Buy
Matrix Scientific	073914	Methyl 5-amino-4H-[1,2,4]triazole-3-carboxylate 95+%	3641-14-3	1g	$278	2021-12-16	Buy

Product number	Packaging	Price	Buy
573787	1g	$47.18	Buy
M328680	500mg	$65	Buy
455626	100mg	$305	Buy
M328680	100mg	$45	Buy
073914	1g	$278	Buy

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Chemical Properties,Uses,Production

Synthesis

67-56-1

3-Amino-1,2,4-triazole-5-carboxylic acid

3641-13-2

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

3641-14-3

To a solution of 5-amino-1H-1,2,4-triazole-3-carboxylic acid (3.9 g, 30.45 mmol) in methanol (100 mL) was slowly added thionyl chloride (SOCl2, 12 g, 100.84 mmol). The reaction mixture was stirred at 70 °C for 48 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The residue was dissolved in water (100 mL) and the pH was adjusted with saturated sodium bicarbonate (NaHCO3) solution to 8. Subsequently, the aqueous phase was extracted with dichloromethane (3 x 50 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl 5-amino-1H-1,2,4-triazole-3-carboxylate as a white solid (800 mg, 65% yield). The product was confirmed by LC/MS (ES, m/z): [M + H]+ 143.0. 1H NMR (300 MHz, DMSO-d6): δ 3.85 (s, 3H).

References

[1] Chemical and Pharmaceutical Bulletin, 2004, vol. 52, # 2, p. 192 - 198
[2] Russian Journal of Applied Chemistry, 2006, vol. 79, # 5, p. 783 - 786
[3] Patent: WO2014/66743, 2014, A1. Location in patent: Paragraph 0146

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate synthesis

Synthesis of Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate from Methanol and 3-Amino-1,2,4-triazole-5-carboxylic acid

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Preparation Products And Raw materials

Raw materials

3-Amino-1,2,4-triazole-5-carboxylic acid Methanol

Preparation Products

3-(morpholin-4-ylcarbonyl)-1H-1,2,4-triazol-5-amine(SALTDATA: FREE) 5-amino-2H-1,2,4-triazole-3-carbohydrazide

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Suppliers

Global( 180)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3999	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
Zhejiang ZETian Fine Chemicals Co. LTD	58
Hubei Jusheng Technology Co.,Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-07-15	Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate 3641-14-3	US $1.00 / KG	1KG	99%	20t	Shaanxi Dideu Medichem Co. Ltd
	2021-07-13	Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate 3641-14-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate
3641-14-3
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate
3641-14-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Spectrum

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate(3641-14-3)¹HNMR

3641-14-3(Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate)Related Search:

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Methyl ethyl 5-amino-2H-1,2,4-triazole-3-carboxylate Methyl 5-amino-4H-1,2,4-triazole-3-carboxylate hydrochloride

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Methyl 3-aMino-1,2,4-triazole-5-carboxylate Methyl 5-aMino-1,2,4-triazole-3-carboxylate Methyl 5-AMino-1H-1,2,4-Triazole-3-Carboxylate Sulfate Salt 5-Amino-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester 96% 1H-1,2,4-Triazole-3-carboxylicacid, 5-amino-, methyl ester 5-Amino-1H-[1, 2, 4]-triazole-3-carboxylic acid methyleester 2,4-triazole-3-carboxylicacid,5-amino-1h-methylester 5-AMINO-1H-1 2 4-TRIAZOLE-3-CARBOXYLIC Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate 3-Amino-5-(methoxycarbonyl)-1,2,4-triazole 1H-5-Amino-1,2,4-trazole-3-caboxylic acid methyl ester 5-Amino-1h-1,2,4-Triazole-3-Carboxylic Acid Methyl Ester Sulfate methyl 5-amino-1H-1,2,4-triazole-3-carboxylate hydrochloride 1H-1,2,4-triazole-3-carboxylic acid, 5-amino-, methyl este methyl 5-amino-1H-1,2,4-triazole-3-carboxylate nitrate 3-amino-1H-1,2,4-triazole-5-carboxylic acid methyl ester methyl 3-azanyl-1H-1,2,4-triazole-5-carboxylate Methyl 5-aMino-2H-1,2,4-triazole-3-carboxylate ethyl 5-aMino-1H-1,2,4-triazole-3-carboxylate Asciminib Impurity 21 5-Amino-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester 3641-14-3 Building Blocks Heterocyclic Building Blocks Triazoles Building Blocks Chemical Synthesis Heterocyclic Building Blocks