MI-1061
- CAS No.
- 1410737-34-6
- Chemical Name:
- MI-1061
- Synonyms
- MI-1061;MI1061,MI 1061;Benzoic acid, 4-[[[(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-1'',2''-dihydro-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indol]-5'-yl]carbonyl]amino]-
- CBNumber:
- CB45821194
- Molecular Formula:
- C30H26Cl2FN3O4
- Molecular Weight:
- 582.45
- MDL Number:
- MOL File:
- 1410737-34-6.mol
| Product description | Number | Pack Size | Price |
| MI-1061 98.22% | CS-0102051 | 1mg | $550 |
| MI-1061 98.22% | CS-0102051 | 5mg | $980 |
| MI-1061 98.22% | CS-0102051 | 10mg | $1500 |
MI-1061 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0102051 | MI-1061 98.22% | 1410737-34-6 | 1mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0102051 | MI-1061 98.22% | 1410737-34-6 | 5mg | $980 | 2021-12-16 | Buy |
| ChemScene | CS-0102051 | MI-1061 98.22% | 1410737-34-6 | 10mg | $1500 | 2021-12-16 | Buy |
MI-1061 Chemical Properties,Uses,Production
Description
MI-1061 is a novel Chemically Stable, Potent, and Efficacious MDM2 Inhibitor.
Uses
MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53 and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity[1].
in vivo
MI-1061 (100 mg/kg; p.o.; daily for 14 days) is capable of achieving tumor regression in the SJSA-1 xenograft tumor model in mice[1].
| Animal Model: | SCID mice bearing SJSA-1 osteosarcoma xenografts[1] |
| Dosage: | 100 mg/kg |
| Administration: | P.o.; daily for 14 days |
| Result: | Demonstrated strong antitumor activity and achieved significant tumor regression. |
References
[1] Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannichring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57(24):10486-98. DOI:10.1021/jm501541j
MI-1061 Preparation Products And Raw materials
Raw materials
Preparation Products
MI-1061 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2993 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| cjbscvictory | 13348960310 | 3003867561@qq.com | China | 10503 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@qq.com | China | 2717 | 58 |
