ChemicalBook
Chinese Japanese Germany Korea

piritramide

piritramide
piritramide structure
CAS No.
302-41-0
Chemical Name:
piritramide
Synonyms
A 65;R 3365;Pirdolan;Piridolan;Dipidolor;Pirtramide;piritramide;Pirinitramide;DipiritraMide;Piritramide (1 mg/mL in Methanol)
CBNumber:
CB4893624
Molecular Formula:
C27H34N4O
Formula Weight:
430.593
MOL File:
302-41-0.mol

piritramide Properties

Melting point:
149-150°
Boiling point:
544.82°C (rough estimate)
Density 
1.0967 (rough estimate)
refractive index 
1.5900 (estimate)
storage temp. 
Controlled Substance, -20°C Freezer
pka
16.19±0.20(Predicted)
FDA UNII
4RP92LYZ2F

piritramide Chemical Properties,Uses,Production

Chemical Properties

Off-White Low Melting Solid

Originator

Dipidolor ,Janssen W. ,Germany,1969

Uses

Piritramide is a synthetic opioid commonly used in Germany and Austria for the analgesia of pediatric patients.

Manufacturing Process

A mixture of 84 parts of 3,3-diphenyl-3-cyanopropyl bromide, 41 parts of 4piperidino-4-piperidinecarboxamide, 64 parts of sodium carbonate, a small amount of potassium iodide and 1,200 parts of anhydrous toluene was stirred, and heated under reflux for 48 hours. At the end of this time the reaction mixture was allowed to cool to room temperature, and 500 parts of water were added. The resultant precipitate was removed by filtration, and triturated with diisopropyl ether. The crystalline material thus obtained was removed by filtration, and recrystallized from 320 parts of acetone, to give 1-(3,3diphenyl-3-cyanopropyl)-4-piperidino-4-piperidinecarboxamide, melting at about 149°C to 150°C.

Therapeutic Function

Analgesic

piritramide Preparation Products And Raw materials

Raw materials

Preparation Products

302-41-0(piritramide )Related Search:


  • DipiritraMide
  • Pirdolan
  • piritramide
  • Pirtramide
  • Pirinitramide
  • A 65
  • Dipidolor
  • Piridolan
  • R 3365
  • 1-[3-cyano-3,3-di(phenyl)propyl]-4-piperidin-1-yl-piperidine-4-carboxamide
  • 1-[3-cyano-3,3-di(phenyl)propyl]-4-piperidin-1-ylpiperidine-4-carboxamide
  • 1-[3-cyano-3,3-di(phenyl)propyl]-4-piperidino-isonipecotamide
  • Piritramide (1.0mg/ml in Acetonitrile)
  • Piritramide (1 mg/mL in Methanol)
  • 302-41-0
  • C27H34N4O
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Copyright 2017 © ChemicalBook. All rights reserved