10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine
![10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Structure](CAS/GIF/70449-94-4.gif)
- CAS No.
- 70449-94-4
- Chemical Name:
- 10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine
- Synonyms
- (+)-MK 801;">cyclohepten-5,10-imine,DIZOCILPINE;5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine;10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine;5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene;5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-;5-Methyl-5,11-epimino-10,11-dihydro-5H-dibenzo[a,d]cycloheptene;Dizocilpinum,Dizocilpina,10,11-dihydro-5-methyl-5H-dibenzo
10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A3100 | (+)-MK801 | 70449-94-4 | 10mg | $48 | 2021-12-16 | Buy |
| ApexBio Technology | A3100 | (+)-MK801 | 70449-94-4 | 10mM(in 1mL DMSO) | $50 | 2021-12-16 | Buy |
| ApexBio Technology | A3100 | (+)-MK801 | 70449-94-4 | 50mg | $186 | 2021-12-16 | Buy |
10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Chemical Properties,Uses,Production
Biological Activity
(+)-mk 801 is a potent antagonist of nmda with ki value of 30.5nm [1].mk 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties. it is found to be a noncompetitive antagonist of nmda. mk 801 can penetrate into the central nervous system. in the in vitro assay, mk 801 binds to rat cerebral cortical membrane with high affinity in a saturable manner. this binding is reversible even when the concentration of mk 801 is up to 100μm. it is also found that the binding shows a regional specificity. most of these binding sites are located in the hippocampus. in rat cortical-slice preparations, mk 801 causes a potent blockade of depolarizing responses to nmda with a high selectivity. this effect is persistent. the blockade can also cause a suppression of the epileptiform activity induced by tetrodotoxin or other neurotoxin [1].
target
NMDA
References
[1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8.
10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Preparation Products And Raw materials
Raw materials
Preparation Products
10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 13823398779 18670069958 | 313359644@qq.com | China | 3195 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9943 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9082 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | 18616377689 | nanfengdrug@163.com | China | 20566 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 13720134139 | orders@jknbiochem.com | China | 5602 | 58 |