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10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine

CAS No.
70449-94-4
Chemical Name:
10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine
Synonyms
(+)-MK 801;">cyclohepten-5,10-imine,DIZOCILPINE;5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine;10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine;5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene;5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-;5-Methyl-5,11-epimino-10,11-dihydro-5H-dibenzo[a,d]cycloheptene;Dizocilpinum,Dizocilpina,10,11-dihydro-5-methyl-5H-dibenzo70449-94-4.mol
Last updated:2023-05-21 10:59:17

10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Properties

Boiling point 320.3±11.0 °C(Predicted)
Density 1.144±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; ≥10.45 mg/mL in DMSO; ≥102.6 mg/mL in EtOH
form oil
pka 7.96±0.40(Predicted)
color brown

10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ApexBio Technology A3100 (+)-MK801 70449-94-4 10mg $48 2021-12-16 Buy
ApexBio Technology A3100 (+)-MK801 70449-94-4 10mM(in 1mL DMSO) $50 2021-12-16 Buy
ApexBio Technology A3100 (+)-MK801 70449-94-4 50mg $186 2021-12-16 Buy
Product number Packaging Price Buy
A3100 10mg $48 Buy
A3100 10mM(in 1mL DMSO) $50 Buy
A3100 50mg $186 Buy

10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Chemical Properties,Uses,Production

Biological Activity

(+)-mk 801 is a potent antagonist of nmda with ki value of 30.5nm [1].mk 801 is a potent anticonvulsant exhibits both anxiolytic and sympathomimetic properties. it is found to be a noncompetitive antagonist of nmda. mk 801 can penetrate into the central nervous system. in the in vitro assay, mk 801 binds to rat cerebral cortical membrane with high affinity in a saturable manner. this binding is reversible even when the concentration of mk 801 is up to 100μm. it is also found that the binding shows a regional specificity. most of these binding sites are located in the hippocampus. in rat cortical-slice preparations, mk 801 causes a potent blockade of depolarizing responses to nmda with a high selectivity. this effect is persistent. the blockade can also cause a suppression of the epileptiform activity induced by tetrodotoxin or other neurotoxin [1].

target

NMDA

References

[1] wong eh, kemp ja, priestley t, knight ar, woodruff gn, iversen ll . the anticonvulsant mk-801 is a potent n-methyl-d-aspartate antagonist. proc natl acad sci u s a. 1986 sep;83(18):7104-8.

10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Preparation Products And Raw materials

Raw materials

Preparation Products

10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Suppliers

Global( 15)Suppliers
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ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32836 60
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139 orders@jknbiochem.com China 5225 58
Changsha Fuzhen Biotechnology Co.,LTD 13823398779 18670069958 313359644@qq.com China 3195 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9943 58
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Taizhou Nanfeng Pharmaceutical Research Institute 18616377689 nanfengdrug@163.com China 20566 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 13720134139 orders@jknbiochem.com China 5602 58

10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine Spectrum

10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine 5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine 5-Methyl-5,11-epimino-10,11-dihydro-5H-dibenzo[a,d]cycloheptene 5-Methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene (+)-MK 801 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl- Dizocilpinum,Dizocilpina,10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine,DIZOCILPINE ">cyclohepten-5,10-imine,DIZOCILPINE Dizocilpinum,Dizocilpina,10,11-dihydro-5-methyl-5H-dibenzo