PRL-3 INHIBITOR I
- CAS No.
- 893449-38-2
- Chemical Name:
- PRL-3 INHIBITOR I
- Synonyms
- P0180;PRL-3 Inhibitor;PRL-3 INHIBITOR I;PRL-3 Inhibitor - CAS 893449-38-2 - Calbiochem;Phosphatase of regenerating liver-3, Inhibitor I;5-(5-Bromo-2-((2-bromobenzyl)oxy)benzylidene)-2-thioxothiazolidin-4-one;5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-;cells,Inhibitor,PRL3 Inhibitor I,invasion,inhibit,PRL-3 Inhibitor I,melanoma,PRL 3 Inhibitor I,B16F10,Phosphatase;Phosphatase of regenerating liver-3, Inhibitor I, 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone
- CBNumber:
- CB4972918
- Molecular Formula:
- C17H11Br2NO2S2
- Molecular Weight:
- 485.21
- MDL Number:
- MFCD11045303
- MOL File:
- 893449-38-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H410 | |||||||||
| Precautionary statements | P261-P273-P305+P351+P338-P501 | |||||||||
| Hazard Codes | Xi,N | |||||||||
| Risk Statements | 36/37/38-50/53 | |||||||||
| Safety Statements | 26-36/37-60-61 | |||||||||
| RIDADR | UN 3077 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
PRL-3 INHIBITOR I price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0108 | PRL-3 Inhibitor I ≥98% (HPLC), solid | 893449-38-2 | 5mg | $105 | 2024-03-01 | Buy |
| Cayman Chemical | 18719 | PRL-3 Inhibitor ≥98% | 893449-38-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18719 | PRL-3 Inhibitor ≥98% | 893449-38-2 | 5mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 18719 | PRL-3 Inhibitor ≥98% | 893449-38-2 | 10mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 18719 | PRL-3 Inhibitor ≥98% | 893449-38-2 | 25mg | $267 | 2024-03-01 | Buy |
PRL-3 INHIBITOR I Chemical Properties,Uses,Production
Description
P0108 (893449-38-2) is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3), IC50=0.9 μM.1? Reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model.2 Sensitizes PRL-3-expressing cancer cells to chemotherapeutics.3 Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells.4
Uses
5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone is a a cell-permeable benzylidene rhodamine that inhibits Phosphatase of regenerating liver 3 (PRL-3).
Definition
ChEBI: 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one is an aromatic ether.
in vitro
prl-3 inhibitor, in a dose-dependent fashion, blocked the dephosphorylation of difmup by prl-3 and strongly suppressed the activity of prl-3 phosphatase in prl-3 overexpressing dld-1 colon tumor cells [dld-1 (prl-3)]. also, prl-3 inhibitor dose-dependently blocked the migration of dld-1 (prl-3) cells, however, it did not inhibit the proliferation of dld-1(prl-3) cells, suggesting that prl-3 inhibitor significantly blocked cell immigration and invasion without cytotoxicity [1].
IC 50
900 nm: blocks human phosphatase of regenerating liver 3 (prl-3) in vitro.
References
1) Ahn et al. (2006), Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors; Bioorg. Med. Chem. Lett., 16 2996 2) Min et al. (2013), Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells; Bioorg. Med. Chem. Lett., 23 3769 3) Zhao et al. (2011), PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy; PLoS One, 6(5) e19798 4) Tian et al. (2012), Phosphatase of regenerating liver-3 directly interacts with integrin β1 and regulates its phosphorylation at tyrosine 783; BMC Biochemistry, 13 22
PRL-3 INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
PRL-3 INHIBITOR I Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3500 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8015 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9833 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |