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ChemicalBook >> CAS DataBase List >>2,4,7-Trichloropyrido[2,3-d]pyrimidine

2,4,7-Trichloropyrido[2,3-d]pyrimidine

2,4,7-Trichloropyrido[2,3-d]pyrimidine Structure
2,4,7-Trichloropyrido[2,3-d]pyrimidine structure
CAS No.
938443-20-0
Chemical Name:
2,4,7-Trichloropyrido[2,3-d]pyrimidine
Synonyms
100232;2,4,7-Trichloropyrido[2,3...;2,4,7-Trichloropyrido[2,3-d]pyrimidine;Pyrido[2,3-d]pyriMidine, 2,4,7-trichloro-;2,4,7-Trichloropyrido[2,3-d]pyrimidine ISO 9001：2015 REACH
CBNumber:
CB52474792
Molecular Formula:
C7H2Cl3N3
Molecular Weight:
234.47
MDL Number:
MFCD11109463
MOL File:
938443-20-0.mol
MSDS File:
SDS
Last updated:2026-05-28 01:55:33
Request For Quotation

2,4,7-Trichloropyrido[2,3-d]pyrimidine Properties

Boiling point 316.4±42.0 °C(Predicted)
Density 1.685±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -2.53±0.30(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C7H2Cl3N3/c8-4-2-1-3-5(9)12-7(10)13-6(3)11-4/h1-2H
InChIKey DNFDLCRLLQVUQK-UHFFFAOYSA-N
SMILES C1(Cl)=NC(Cl)=C2C=CC(Cl)=NC2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H318
Precautionary statements  P264-P270-P280-P301+P310-P305+P351+P338-P405
Hazard Codes  T
Risk Statements  25-41
Safety Statements  26-39-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HS Code  2933998090

2,4,7-Trichloropyrido[2,3-d]pyrimidine price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SYX00244 2,4,7-Trichloropyrido[2,3-d]pyrimidine Aldrich 938443-20-0 1g $1490 2023-01-07 Buy
Apolloscientific OR471510 2,4,7-Trichloropyrido[2,3-d]pyrimidine 95% 938443-20-0 100mg $21 2026-06-04 Buy
Apolloscientific OR471510 2,4,7-Trichloropyrido[2,3-d]pyrimidine 95% 938443-20-0 250mg $44 2026-06-04 Buy
Apolloscientific OR471510 2,4,7-Trichloropyrido[2,3-d]pyrimidine 95% 938443-20-0 1g $124 2026-06-04 Buy
Apolloscientific OR471510 2,4,7-Trichloropyrido[2,3-d]pyrimidine 95% 938443-20-0 5g $613 2026-06-04 Buy
Product number Packaging Price Buy
SYX00244 1g $1490 Buy
OR471510 100mg $21 Buy
OR471510 250mg $44 Buy
OR471510 1g $124 Buy
OR471510 5g $613 Buy

2,4,7-Trichloropyrido[2,3-d]pyrimidine Chemical Properties, Uses, Production

Uses

2,4,7-Trichloropyrido[2,3-d]pyrimidine is used in the synthetic preparation of dual mTORC1/mTORC2 inhibitors and the discovery of AZD8055 and AZD2014 as potential antitumor agents.

Synthesis

7-Chloropyrido[2,3-d]pyrimidine-2,4-diol

938443-19-7

2,4,7-Trichloropyrido[2,3-d]pyrimidine

938443-20-0

The general procedure for the synthesis of 2,4,7-trichloropyrido[2,3-d]pyrimidine (Inter.5) using 7-chloropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (Inter.4) as a starting material is as follows: To a stirred anhydrous toluene suspension of 0.5 M Inter.4 (1 equiv.) in an inert atmosphere was slowly added diisopropylethylamine (3 equivalent). The reaction mixture was heated to 70 °C and maintained for 30 min and subsequently cooled to room temperature. Next, phosphorous oxychloride (POCl3, 3 eq.) was added and the reaction mixture was heated to 100 °C for 2.5 hours. Upon completion of the reaction, the mixture was cooled and concentrated under vacuum to give a crude product slurry. The crude product was suspended in ethyl acetate (EtOAc) and filtered through a thin diatomaceous earth pad. The filtrate was concentrated under vacuum to give a brown oil. The oily substance was dissolved in dichloromethane (CH2Cl2) and stirred on silica gel for 30 minutes. Afterwards, the silica gel was removed by filtration and the filtrate was concentrated. The crude product was purified by fast chromatography (silica gel, SiO2) to afford analytically pure 2,4,7-trichloropyrido[2,3-d]pyrimidine (48% yield, 96% purity). Mass spectrometry (LC-MS, ESP) analysis resulted in: m/z 234 [M + H]+, retention time (R/T) = 4.21 min.

References

[1] Patent: WO2007/60404, 2007, A1. Location in patent: Page/Page column 57; 59
[2] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 101
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1212 - 1216
[4] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 102-103
[5] Patent: CN102887895, 2016, B. Location in patent: Paragraph 0310; 0313; 0314

2,4,7-Trichloropyrido[2,3-d]pyrimidine synthesis

938443-19-7
938443-20-0
Synthesis of 2,4,7-Trichloropyrido[2,3-d]pyrimidine from 7-Chloropyrido[2,3-d]pyrimidine-2,4-diol

2,4,7-Trichloropyrido[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Pyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione 2,6-Dichloronicotinic acid 7-Chloropyrido[2,3-d]pyrimidine-2,4-diol 2-Amino-6-chloronicotinamide 2-Amino-5-chloropyridine-3-carboxylic acid
trichlorophosphate N,N-Diisopropylethylamine

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Preparation Products

4-(2,7-dichloropyrido[2,3-d]pyriMidin-4-yl)Morpholine DADEPYLIPQQG PACRITINIB (JAK inhibitor)

2,4,7-Trichloropyrido[2,3-d]pyrimidine Suppliers

Global Suppliers ( 118)
Supplier Tel Email Country ProdList Advantage
langwaychem 21-67639201 13601755340 customer@langwaychem.com China 109 58
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shangchem Co., Ltd. +86-21-68182121 China 881 52
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China Langchem Inc. 0086-21-58956006 China 7798 57
ChemShuttle, Inc. 0510-83588313-811 18800520310 sales@chemshuttle.com China 2999 62
Sci General Material & Chemical Ltd 021-58388037;21-58388037 13472507714 35177634@qq.com;1589045147@qq.com China 795 55
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Hunan Furui Biopharma Technology Co., Ltd. 15901640172，19275032510 15901640172 sales03@hn-furui.com China 380 55
Supplier Advantage
langwaychem 58
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shangchem Co., Ltd. 52
Shanghai Hanhong Scientific Co.,Ltd. 64
China Langchem Inc. 57
ChemShuttle, Inc. 62
Sci General Material & Chemical Ltd 55
Shanghai Topbiochem Technology Co., Ltd 58
Haoyuan Chemexpress Co., Ltd. 61
Hunan Furui Biopharma Technology Co., Ltd. 55

View Latest Price from 2,4,7-Trichloropyrido[2,3-d]pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4,7-Trichloropyrido[2,3-d]pyrimidine pictures 2025-04-04 2,4,7-Trichloropyrido[2,3-d]pyrimidine
938443-20-0
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2,4,7-trichloropyrido[2,3-d]pyrimidine pictures 2019-12-29 2,4,7-trichloropyrido[2,3-d]pyrimidine
938443-20-0
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2,4,7-Trichloropyrido[2,3-d]pyrimidine pictures 2019-07-06 2,4,7-Trichloropyrido[2,3-d]pyrimidine
938443-20-0
 $1.00 1KG 99% Career Henan Chemical Co

2,4,7-Trichloropyrido[2,3-d]pyrimidine Spectrum

2,4,7-Trichloropyrido[2,3-d]pyrimidine(938443-20-0)1HNMR

938443-20-0 (2,4,7-Trichloropyrido[2,3-d]pyrimidine) Related Search:

3,5,6-Trichloropyrid 2,4-Dichloropyrido[2,3-d]pyrimidine 4-Chloropyrido[2,3-d]pyrimidine 6-bromo-2,4-dichloropyrido[2,3-d]pyrimidine Pyrido[2,3-d]pyrimidine, 2,4,5,7-tetrachloro-
Pyrido[2,3-d]pyrimidine, 4,7-dichloro- (9CI)

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2,4,7-Trichloropyrido[2,3-d]pyrimidine 2,4,7-Trichloropyrido[2,3... Pyrido[2,3-d]pyriMidine, 2,4,7-trichloro- 100232 2,4,7-Trichloropyrido[2,3-d]pyrimidine ISO 9001：2015 REACH 938443-20-0 C7H2Cl3N3